Plasma concentrations of the enantiomers of halofantrine and its main metabolite in malaria patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-07

AUTHORS

F. Gimenez, C. Gillotin, L. K. Basco, O. Bouchaud, A. -F. Aubry, I. W. Wainer, J. Le Bras, R. Farinotti

ABSTRACT

The plasma concentrations of the enantiomers of halofantrine and its N-desbutyl metabolite in six patients with malaria were measured after oral administration of 3 x 750 mg doses of micronised, racemic halofantrine hydrochloride given at 6-hour intervals. Significant differences were observed between the plasma concentrations of the enantiomers both of halofantrine and its N-monodesbutyl metabolite. AUC(0)84h values were higher for (+)halofantrine (9917 micrograms.ml-1.h) than for (-)-halofantrine (6127 micrograms.ml-1.h). The clinical significance of these observations is not known. The isomers have equipotent activity in vitro but their relative toxicity has not yet been assessed. More... »

PAGES

561-562

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00196116

DOI

http://dx.doi.org/10.1007/bf00196116

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008549209

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7995326


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