Localization of the human HF.10 finger gene on a chromosome region (3p21–22) frequently deleted in human cancers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-04

AUTHORS

Emilio Donti, Luisa Lanfrancone, Kay Huebner, Anna Pascucci, Giovanna Venti, Gina Pengue, Fausto Grignani, Carlo M. Croce, Luigi Lania, Pier Giuseppe Pelicci

ABSTRACT

The finger motif is a tandemly repeated DNA-binding domain recently identified in the primary structure of several eukaryotic transcriptional regulatory proteins. It has been proposed that some members of the finger-gene family are implicated in both normal cell proliferation and differentiation. We isolated several human finger genes by means of hybridization with a finger motif-containing DNA probe. One of these finger genes, HF.10, is expressed at low levels in a variety of human tissues and is down-regulated during the in vitro terminal differentiation of human leukemic myeloid cell lines. By in situ hybridization experiments and analysis of interspecific somatic cell hybrids we mapped the HF.10 gene to 3p21–22, a chromosome region frequently involved in karyotypic rearrangements associated with lung and renal cancer. More... »

PAGES

391-395

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00195806

DOI

http://dx.doi.org/10.1007/bf00195806

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011393760

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2108922


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