Human leukocyte alpha interferon-induced transient neurotoxicity in children View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-06

AUTHORS

Julie A. Katz, Donald H. Mahoney, C. Philip Steuber, Donald J. Fernbach

ABSTRACT

Neuropsychiatric complications with recombinant alpha interferon (rIFN-alpha) have been described in adults. Little documentation of similar toxicity in pediatric phase I and phase II trials exists. Two children, treated with rIFN-alpha, experienced confusion, somnolence and syncope, associated with transient electroencephalographic abnormalities. Symptoms abated and electroencephalographic findings improved with termination of therapy. Readministration at lower dosages has not been associated with recurrence of neurotoxicity. More... »

PAGES

115-120

References to SciGraph publications

  • 1983-03. Central nervous system toxicity of interferon in BRITISH JOURNAL OF CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00195369

    DOI

    http://dx.doi.org/10.1007/bf00195369

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049779609

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3170131


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