Ontology type: schema:ScholarlyArticle
1994-09
AUTHORSB. K. Krämer, A. Schwab, N. Braun, T. Risler, F. Strutz, G. A. Müller
ABSTRACTThe pharmacokinetics of torasemide, a new loop diuretic, as well as its active metabolites M1 and M3, and its inactive main metabolite, M5, were studied in 12 patients with end-stage renal failure during single i.v. (n = 6) or single oral (n = 6) dosing of 200 mg torasemide, and during chronic oral treatment for 9 days (n = 12). The elimination half-life (t1/2) of torasemide was unchanged in renal failure, whereas t1/2 of the torasemide metabolites M1, M3, and M5 were markedly prolonged. However t1/2 as well as the area under the plasma level time curve of torasemide and its metabolites were unchanged during chronic compared to acute administration. The results of this study suggest that despite the increased half-life of torasemide metabolites M1, M3 and M5 in end-stage renal failure patients, no accumulation of the parent drug torasemide and its metabolites during chronic dosing is demonstrable. More... »
PAGES157-159
http://scigraph.springernature.com/pub.10.1007/bf00194966
DOIhttp://dx.doi.org/10.1007/bf00194966
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1038016488
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/7859803
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Diuretics",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Half-Life",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Kidney Failure, Chronic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sulfonamides",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Torsemide",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Regensburg",
"id": "https://www.grid.ac/institutes/grid.7727.5",
"name": [
"Klinik und Poliklinik f\u00fcr Innere Medizin II, Universit\u00e4t Regensburg, D-93042, Regensburg, Germany"
],
"type": "Organization"
},
"familyName": "Kr\u00e4mer",
"givenName": "B. K.",
"id": "sg:person.010757421312.26",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010757421312.26"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of T\u00fcbingen",
"id": "https://www.grid.ac/institutes/grid.10392.39",
"name": [
"Medizinische Klinik III, Universit\u00e4t T\u00fcbingen, Germany"
],
"type": "Organization"
},
"familyName": "Schwab",
"givenName": "A.",
"id": "sg:person.01210103056.65",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210103056.65"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of T\u00fcbingen",
"id": "https://www.grid.ac/institutes/grid.10392.39",
"name": [
"Medizinische Klinik III, Universit\u00e4t T\u00fcbingen, Germany"
],
"type": "Organization"
},
"familyName": "Braun",
"givenName": "N.",
"id": "sg:person.0701647656.28",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701647656.28"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of T\u00fcbingen",
"id": "https://www.grid.ac/institutes/grid.10392.39",
"name": [
"Medizinische Klinik III, Universit\u00e4t T\u00fcbingen, Germany"
],
"type": "Organization"
},
"familyName": "Risler",
"givenName": "T.",
"id": "sg:person.01001455477.84",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001455477.84"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Zentrum Innere Medizin, Abteilung Nephrologie/Rheumatologie, Universit\u00e4t G\u00f6ttingen, Germany"
],
"type": "Organization"
},
"familyName": "Strutz",
"givenName": "F.",
"id": "sg:person.0631207401.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631207401.33"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Zentrum Innere Medizin, Abteilung Nephrologie/Rheumatologie, Universit\u00e4t G\u00f6ttingen, Germany"
],
"type": "Organization"
},
"familyName": "M\u00fcller",
"givenName": "G. A.",
"id": "sg:person.012650516557.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012650516557.76"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/bf00541460",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003363483",
"https://doi.org/10.1007/bf00541460"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00541460",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003363483",
"https://doi.org/10.1007/bf00541460"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.2165/00003495-199141010-00008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030232176",
"https://doi.org/10.2165/00003495-199141010-00008"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0731-7085(87)80029-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030921705"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.2165/00003495-199100413-00008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051932336",
"https://doi.org/10.2165/00003495-199100413-00008"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079662550",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079708567",
"type": "CreativeWork"
}
],
"datePublished": "1994-09",
"datePublishedReg": "1994-09-01",
"description": "The pharmacokinetics of torasemide, a new loop diuretic, as well as its active metabolites M1 and M3, and its inactive main metabolite, M5, were studied in 12 patients with end-stage renal failure during single i.v. (n = 6) or single oral (n = 6) dosing of 200 mg torasemide, and during chronic oral treatment for 9 days (n = 12). The elimination half-life (t1/2) of torasemide was unchanged in renal failure, whereas t1/2 of the torasemide metabolites M1, M3, and M5 were markedly prolonged. However t1/2 as well as the area under the plasma level time curve of torasemide and its metabolites were unchanged during chronic compared to acute administration. The results of this study suggest that despite the increased half-life of torasemide metabolites M1, M3 and M5 in end-stage renal failure patients, no accumulation of the parent drug torasemide and its metabolites during chronic dosing is demonstrable.",
"genre": "research_article",
"id": "sg:pub.10.1007/bf00194966",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1054337",
"issn": [
"0031-6970",
"1432-1041"
],
"name": "European Journal of Clinical Pharmacology",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "47"
}
],
"name": "Pharmacokinetics of torasemide and its metabolites in end-stage renal disease",
"pagination": "157-159",
"productId": [
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/bf00194966"
]
},
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"b51936a38794d754ce8e1fc379410d338bf54f484a401af4c2092d5104e8753c"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1038016488"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"1256165"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"7859803"
]
}
],
"sameAs": [
"https://doi.org/10.1007/bf00194966",
"https://app.dimensions.ai/details/publication/pub.1038016488"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-15T08:52",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000374_0000000374/records_119741_00000000.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007/BF00194966"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00194966'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00194966'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00194966'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00194966'
This table displays all metadata directly associated to this object as RDF triples.
158 TRIPLES
21 PREDICATES
42 URIs
28 LITERALS
16 BLANK NODES