Pharmacokinetics of torasemide and its metabolites in end-stage renal disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-09

AUTHORS

B. K. Krämer, A. Schwab, N. Braun, T. Risler, F. Strutz, G. A. Müller

ABSTRACT

The pharmacokinetics of torasemide, a new loop diuretic, as well as its active metabolites M1 and M3, and its inactive main metabolite, M5, were studied in 12 patients with end-stage renal failure during single i.v. (n = 6) or single oral (n = 6) dosing of 200 mg torasemide, and during chronic oral treatment for 9 days (n = 12). The elimination half-life (t1/2) of torasemide was unchanged in renal failure, whereas t1/2 of the torasemide metabolites M1, M3, and M5 were markedly prolonged. However t1/2 as well as the area under the plasma level time curve of torasemide and its metabolites were unchanged during chronic compared to acute administration. The results of this study suggest that despite the increased half-life of torasemide metabolites M1, M3 and M5 in end-stage renal failure patients, no accumulation of the parent drug torasemide and its metabolites during chronic dosing is demonstrable. More... »

PAGES

157-159

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00194966

DOI

http://dx.doi.org/10.1007/bf00194966

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038016488

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7859803


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diuretics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Half-Life", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Failure, Chronic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sulfonamides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Torsemide", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Regensburg", 
          "id": "https://www.grid.ac/institutes/grid.7727.5", 
          "name": [
            "Klinik und Poliklinik f\u00fcr Innere Medizin II, Universit\u00e4t Regensburg, D-93042, Regensburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kr\u00e4mer", 
        "givenName": "B. K.", 
        "id": "sg:person.010757421312.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010757421312.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of T\u00fcbingen", 
          "id": "https://www.grid.ac/institutes/grid.10392.39", 
          "name": [
            "Medizinische Klinik III, Universit\u00e4t T\u00fcbingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schwab", 
        "givenName": "A.", 
        "id": "sg:person.01210103056.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210103056.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of T\u00fcbingen", 
          "id": "https://www.grid.ac/institutes/grid.10392.39", 
          "name": [
            "Medizinische Klinik III, Universit\u00e4t T\u00fcbingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Braun", 
        "givenName": "N.", 
        "id": "sg:person.0701647656.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701647656.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of T\u00fcbingen", 
          "id": "https://www.grid.ac/institutes/grid.10392.39", 
          "name": [
            "Medizinische Klinik III, Universit\u00e4t T\u00fcbingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Risler", 
        "givenName": "T.", 
        "id": "sg:person.01001455477.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001455477.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Zentrum Innere Medizin, Abteilung Nephrologie/Rheumatologie, Universit\u00e4t G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Strutz", 
        "givenName": "F.", 
        "id": "sg:person.0631207401.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631207401.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Zentrum Innere Medizin, Abteilung Nephrologie/Rheumatologie, Universit\u00e4t G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "M\u00fcller", 
        "givenName": "G. A.", 
        "id": "sg:person.012650516557.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012650516557.76"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00541460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003363483", 
          "https://doi.org/10.1007/bf00541460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00541460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003363483", 
          "https://doi.org/10.1007/bf00541460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003495-199141010-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030232176", 
          "https://doi.org/10.2165/00003495-199141010-00008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0731-7085(87)80029-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030921705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003495-199100413-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051932336", 
          "https://doi.org/10.2165/00003495-199100413-00008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079662550", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079708567", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1994-09", 
    "datePublishedReg": "1994-09-01", 
    "description": "The pharmacokinetics of torasemide, a new loop diuretic, as well as its active metabolites M1 and M3, and its inactive main metabolite, M5, were studied in 12 patients with end-stage renal failure during single i.v. (n = 6) or single oral (n = 6) dosing of 200 mg torasemide, and during chronic oral treatment for 9 days (n = 12). The elimination half-life (t1/2) of torasemide was unchanged in renal failure, whereas t1/2 of the torasemide metabolites M1, M3, and M5 were markedly prolonged. However t1/2 as well as the area under the plasma level time curve of torasemide and its metabolites were unchanged during chronic compared to acute administration. The results of this study suggest that despite the increased half-life of torasemide metabolites M1, M3 and M5 in end-stage renal failure patients, no accumulation of the parent drug torasemide and its metabolites during chronic dosing is demonstrable.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf00194966", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1054337", 
        "issn": [
          "0031-6970", 
          "1432-1041"
        ], 
        "name": "European Journal of Clinical Pharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "47"
      }
    ], 
    "name": "Pharmacokinetics of torasemide and its metabolites in end-stage renal disease", 
    "pagination": "157-159", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00194966"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b51936a38794d754ce8e1fc379410d338bf54f484a401af4c2092d5104e8753c"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1038016488"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "1256165"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7859803"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00194966", 
      "https://app.dimensions.ai/details/publication/pub.1038016488"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T08:52", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000374_0000000374/records_119741_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF00194966"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00194966'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00194966'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00194966'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00194966'


 

This table displays all metadata directly associated to this object as RDF triples.

158 TRIPLES      21 PREDICATES      42 URIs      28 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00194966 schema:about N2e61955f16df42eaa278d9fa1baed55c
2 N665dbc5676d346e4b181628b7d8073b7
3 N66658e0fa6a44676ade3ef84ed85b15f
4 N84afd67409764fbfaa8a06c7205c246e
5 Nd2b9080d25eb4ba1b06e942b3ddc94ab
6 Ndfc5597b93324c9db6c7801cbc25d448
7 Nfd549f9233f64090a8070ff74d7a13b7
8 anzsrc-for:11
9 anzsrc-for:1103
10 schema:author Nc716e47753e34b82b3511fbd428f88fd
11 schema:citation sg:pub.10.1007/bf00541460
12 sg:pub.10.2165/00003495-199100413-00008
13 sg:pub.10.2165/00003495-199141010-00008
14 https://app.dimensions.ai/details/publication/pub.1079662550
15 https://app.dimensions.ai/details/publication/pub.1079708567
16 https://doi.org/10.1016/0731-7085(87)80029-8
17 schema:datePublished 1994-09
18 schema:datePublishedReg 1994-09-01
19 schema:description The pharmacokinetics of torasemide, a new loop diuretic, as well as its active metabolites M1 and M3, and its inactive main metabolite, M5, were studied in 12 patients with end-stage renal failure during single i.v. (n = 6) or single oral (n = 6) dosing of 200 mg torasemide, and during chronic oral treatment for 9 days (n = 12). The elimination half-life (t1/2) of torasemide was unchanged in renal failure, whereas t1/2 of the torasemide metabolites M1, M3, and M5 were markedly prolonged. However t1/2 as well as the area under the plasma level time curve of torasemide and its metabolites were unchanged during chronic compared to acute administration. The results of this study suggest that despite the increased half-life of torasemide metabolites M1, M3 and M5 in end-stage renal failure patients, no accumulation of the parent drug torasemide and its metabolites during chronic dosing is demonstrable.
20 schema:genre research_article
21 schema:inLanguage en
22 schema:isAccessibleForFree false
23 schema:isPartOf Nba844636e87c4637b11d4233121cc3c5
24 Nfa18b52811444d04b733133cf90dfbfc
25 sg:journal.1054337
26 schema:name Pharmacokinetics of torasemide and its metabolites in end-stage renal disease
27 schema:pagination 157-159
28 schema:productId N2d458397736b45f18ac158491fddb821
29 N3adfbc20eb494b82a10d1ade912cc4e6
30 N5b5b7ec44c974424b17e3aae56728a88
31 Na7164c1369574c08b6f81d32a9fa2801
32 Nc46bc1bd8db543278b84cff235d903dd
33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038016488
34 https://doi.org/10.1007/bf00194966
35 schema:sdDatePublished 2019-04-15T08:52
36 schema:sdLicense https://scigraph.springernature.com/explorer/license/
37 schema:sdPublisher Nab8a3f18e3cb424294c1c82744d2373c
38 schema:url http://link.springer.com/10.1007/BF00194966
39 sgo:license sg:explorer/license/
40 sgo:sdDataset articles
41 rdf:type schema:ScholarlyArticle
42 N06226534c6a7493f9f9282b0802faa2e rdf:first sg:person.01001455477.84
43 rdf:rest Nd3726366dda34c55b3b529a5de1063e2
44 N0c262430c30b464a872fe91a38494812 rdf:first sg:person.012650516557.76
45 rdf:rest rdf:nil
46 N2780907dc48b4819830fffb2e6615981 rdf:first sg:person.01210103056.65
47 rdf:rest N8d7684c8b38840dbbb4fbe0d74478623
48 N2d458397736b45f18ac158491fddb821 schema:name doi
49 schema:value 10.1007/bf00194966
50 rdf:type schema:PropertyValue
51 N2e61955f16df42eaa278d9fa1baed55c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
52 schema:name Sulfonamides
53 rdf:type schema:DefinedTerm
54 N3adfbc20eb494b82a10d1ade912cc4e6 schema:name readcube_id
55 schema:value b51936a38794d754ce8e1fc379410d338bf54f484a401af4c2092d5104e8753c
56 rdf:type schema:PropertyValue
57 N5b5b7ec44c974424b17e3aae56728a88 schema:name pubmed_id
58 schema:value 7859803
59 rdf:type schema:PropertyValue
60 N665dbc5676d346e4b181628b7d8073b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
61 schema:name Half-Life
62 rdf:type schema:DefinedTerm
63 N66658e0fa6a44676ade3ef84ed85b15f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
64 schema:name Middle Aged
65 rdf:type schema:DefinedTerm
66 N84afd67409764fbfaa8a06c7205c246e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Torsemide
68 rdf:type schema:DefinedTerm
69 N8d7684c8b38840dbbb4fbe0d74478623 rdf:first sg:person.0701647656.28
70 rdf:rest N06226534c6a7493f9f9282b0802faa2e
71 Na7164c1369574c08b6f81d32a9fa2801 schema:name dimensions_id
72 schema:value pub.1038016488
73 rdf:type schema:PropertyValue
74 Nab8a3f18e3cb424294c1c82744d2373c schema:name Springer Nature - SN SciGraph project
75 rdf:type schema:Organization
76 Nba844636e87c4637b11d4233121cc3c5 schema:issueNumber 2
77 rdf:type schema:PublicationIssue
78 Nc46bc1bd8db543278b84cff235d903dd schema:name nlm_unique_id
79 schema:value 1256165
80 rdf:type schema:PropertyValue
81 Nc716e47753e34b82b3511fbd428f88fd rdf:first sg:person.010757421312.26
82 rdf:rest N2780907dc48b4819830fffb2e6615981
83 Nd2b9080d25eb4ba1b06e942b3ddc94ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Kidney Failure, Chronic
85 rdf:type schema:DefinedTerm
86 Nd3726366dda34c55b3b529a5de1063e2 rdf:first sg:person.0631207401.33
87 rdf:rest N0c262430c30b464a872fe91a38494812
88 Ndfc5597b93324c9db6c7801cbc25d448 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Diuretics
90 rdf:type schema:DefinedTerm
91 Ne870c73e65444aac83e8060e494c98c4 schema:name Zentrum Innere Medizin, Abteilung Nephrologie/Rheumatologie, Universität Göttingen, Germany
92 rdf:type schema:Organization
93 Nf4ed574346364ae0b425839683ed5373 schema:name Zentrum Innere Medizin, Abteilung Nephrologie/Rheumatologie, Universität Göttingen, Germany
94 rdf:type schema:Organization
95 Nfa18b52811444d04b733133cf90dfbfc schema:volumeNumber 47
96 rdf:type schema:PublicationVolume
97 Nfd549f9233f64090a8070ff74d7a13b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Humans
99 rdf:type schema:DefinedTerm
100 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
101 schema:name Medical and Health Sciences
102 rdf:type schema:DefinedTerm
103 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
104 schema:name Clinical Sciences
105 rdf:type schema:DefinedTerm
106 sg:journal.1054337 schema:issn 0031-6970
107 1432-1041
108 schema:name European Journal of Clinical Pharmacology
109 rdf:type schema:Periodical
110 sg:person.01001455477.84 schema:affiliation https://www.grid.ac/institutes/grid.10392.39
111 schema:familyName Risler
112 schema:givenName T.
113 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001455477.84
114 rdf:type schema:Person
115 sg:person.010757421312.26 schema:affiliation https://www.grid.ac/institutes/grid.7727.5
116 schema:familyName Krämer
117 schema:givenName B. K.
118 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010757421312.26
119 rdf:type schema:Person
120 sg:person.01210103056.65 schema:affiliation https://www.grid.ac/institutes/grid.10392.39
121 schema:familyName Schwab
122 schema:givenName A.
123 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210103056.65
124 rdf:type schema:Person
125 sg:person.012650516557.76 schema:affiliation Nf4ed574346364ae0b425839683ed5373
126 schema:familyName Müller
127 schema:givenName G. A.
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012650516557.76
129 rdf:type schema:Person
130 sg:person.0631207401.33 schema:affiliation Ne870c73e65444aac83e8060e494c98c4
131 schema:familyName Strutz
132 schema:givenName F.
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631207401.33
134 rdf:type schema:Person
135 sg:person.0701647656.28 schema:affiliation https://www.grid.ac/institutes/grid.10392.39
136 schema:familyName Braun
137 schema:givenName N.
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701647656.28
139 rdf:type schema:Person
140 sg:pub.10.1007/bf00541460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003363483
141 https://doi.org/10.1007/bf00541460
142 rdf:type schema:CreativeWork
143 sg:pub.10.2165/00003495-199100413-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051932336
144 https://doi.org/10.2165/00003495-199100413-00008
145 rdf:type schema:CreativeWork
146 sg:pub.10.2165/00003495-199141010-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030232176
147 https://doi.org/10.2165/00003495-199141010-00008
148 rdf:type schema:CreativeWork
149 https://app.dimensions.ai/details/publication/pub.1079662550 schema:CreativeWork
150 https://app.dimensions.ai/details/publication/pub.1079708567 schema:CreativeWork
151 https://doi.org/10.1016/0731-7085(87)80029-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030921705
152 rdf:type schema:CreativeWork
153 https://www.grid.ac/institutes/grid.10392.39 schema:alternateName University of Tübingen
154 schema:name Medizinische Klinik III, Universität Tübingen, Germany
155 rdf:type schema:Organization
156 https://www.grid.ac/institutes/grid.7727.5 schema:alternateName University of Regensburg
157 schema:name Klinik und Poliklinik für Innere Medizin II, Universität Regensburg, D-93042, Regensburg, Germany
158 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...