Comparative efficacy and tolerance of ibuprofen syrup and acetaminophen syrup in children with pyrexia associated with infectious diseases and treated ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-04

AUTHORS

E. Autret, G. Breart, A. P. Jonville, S. Courcier, C. Lassale, J. M. Goehrs

ABSTRACT

A double-blind, randomised, parallel group study has been done comparing the efficacy and tolerability of 7.5 mg/kg ibuprofen syrup (n=77) and 10 mg·kg−1 acetaminophen syrup (n=77) in 154 children (6 months to 5 years) with fever (≥38°C) associated with infectious diseases and treated with antibiotic therapy.The area under the percentage reduction in temperature curve captured the net effect of each drug and provided the best estimate for comparison of efficacy during a defined period. Temperature evolution over time was not significantly different between the two groups. Nevertheless, the temperature reduction over the first 4 h of treatment (H0–H4) was significantly higher after ibuprofen (60%) than acetaminophen (45%). Both ibuprofen and acetaminophen were well tolerated.In conclusion, significant antipyretic activity, good tolerability and its availability as a syrup make ibuprofen an effective means of fever control in children. More... »

PAGES

197-201

References to SciGraph publications

  • 1989-07. Ibuprofen, acetaminophen, and placebo treatment of febrile children in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00192548

    DOI

    http://dx.doi.org/10.1007/bf00192548

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1015678397

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8070499


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    202 grid-institutes:grid.7429.8 schema:alternateName INSERM U 149, Paris, France
    203 schema:name INSERM U 149, Paris, France
    204 rdf:type schema:Organization
     




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