The effect of ciclotropium on human heart rate View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-06

AUTHORS

R. W. Ding, R. E. Port, K. Ortmann, B. Liebmann, H. Spahn-Langguth, E. Mutschler, E. Weber

ABSTRACT

Ciclotropium is a recently developed parasympathicolytic agent. Plasma concentration and heart rate increase (the most prominent anticholinergic effects) were measured in 12 healthy subjects before, during and after a 15-min intravenous infusion of 10 mg ciclotropium. The effect was described by using either a linear or a nonlinear (Emax) effect model linked to a linear three-compartment kinetic model via an effect compartment. Maximum heart rate increase was 33 (10) beats.min-1, and half-value duration of effect was 41 (9) min. Total plasma clearance was 0.51 (0.13) l.min-1, and mean terminal elimination half-life was 12(4) h, whereas the equilibration half-lives of drug removal from the effect compartment ranged from 2 to 14 min. More... »

PAGES

455-459

References to SciGraph publications

  • 1981-12. Understanding the Dose-Effect Relationship in CLINICAL PHARMACOKINETICS
  • 1977-10. Estimation of population characteristics of pharmacokinetic parameters from routine clinical data in JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00191911

    DOI

    http://dx.doi.org/10.1007/bf00191911

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010331329

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7957543


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