Intravenous teicoplanin does not prevent Clostridium difficile associated diarrhea View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-11

AUTHORS

C. Wenisch, E. Etzersdorfer, S. Breyer, W. Graninger

ABSTRACT

A 59-year-old man with the diagnosis of endocarditis of the mitral valve due to Streptococcus mitis was treated with penicillin G, gentamicin, and later with clindamycin as inpatient for 3 weeks. Thereafter outpatient therapy with parenteral teicoplanin 3 × per week was initiated. After 17 days of teicoplanin treatment he developed severe diarrhea, and stool samples were positive for Clostridium difficile toxin. In addition to the ongoing parenteral therapy with teicoplanin, oral teicoplanin was administered. On the third day of this regimen the diarrhea and other disabling symptoms subsided, and test results for C. difficile toxin became negative. Oral teicoplanin was continued for 10 days and cleared C. difficile effectively after treatment as assessed by consecutive stool cultures (until 60 days thereafter). The parenteral administration of teicoplanin could not prevent the onset of C. difficile associated diarrhea in this patient, who previously had been treated with clindamycin. Thus, the administration of parenteral teicoplanin does not seem to be a treatment option for C. difficile associated diarrhea in patients in which oral therapy is not possible. More... »

PAGES

922-924

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00190753

DOI

http://dx.doi.org/10.1007/bf00190753

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049116532

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7894224


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0304", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medicinal and Biomolecular Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clostridium difficile", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diarrhea", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enterocolitis, Pseudomembranous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Injections, Intravenous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Teicoplanin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Abteilung f\u00fcr Infektionen, Innere Medizin I, Universit\u00e4tsklinik Wien, W\u00e4hringer G\u00fcrtel 18-20, A-1090, Wien, Austria", 
          "id": "http://www.grid.ac/institutes/grid.488389.6", 
          "name": [
            "Abteilung f\u00fcr Infektionen, Innere Medizin I, Universit\u00e4tsklinik Wien, W\u00e4hringer G\u00fcrtel 18-20, A-1090, Wien, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wenisch", 
        "givenName": "C.", 
        "id": "sg:person.015376635734.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015376635734.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Abteilung f\u00fcr Infektionen, Innere Medizin I, Universit\u00e4tsklinik Wien, W\u00e4hringer G\u00fcrtel 18-20, A-1090, Wien, Austria", 
          "id": "http://www.grid.ac/institutes/grid.488389.6", 
          "name": [
            "Abteilung f\u00fcr Infektionen, Innere Medizin I, Universit\u00e4tsklinik Wien, W\u00e4hringer G\u00fcrtel 18-20, A-1090, Wien, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Etzersdorfer", 
        "givenName": "E.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Abteilung f\u00fcr Infektionen, Innere Medizin I, Universit\u00e4tsklinik Wien, W\u00e4hringer G\u00fcrtel 18-20, A-1090, Wien, Austria", 
          "id": "http://www.grid.ac/institutes/grid.488389.6", 
          "name": [
            "Abteilung f\u00fcr Infektionen, Innere Medizin I, Universit\u00e4tsklinik Wien, W\u00e4hringer G\u00fcrtel 18-20, A-1090, Wien, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Breyer", 
        "givenName": "S.", 
        "id": "sg:person.014412360064.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014412360064.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Abteilung f\u00fcr Infektionen, Innere Medizin I, Universit\u00e4tsklinik Wien, W\u00e4hringer G\u00fcrtel 18-20, A-1090, Wien, Austria", 
          "id": "http://www.grid.ac/institutes/grid.488389.6", 
          "name": [
            "Abteilung f\u00fcr Infektionen, Innere Medizin I, Universit\u00e4tsklinik Wien, W\u00e4hringer G\u00fcrtel 18-20, A-1090, Wien, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Graninger", 
        "givenName": "W.", 
        "id": "sg:person.013723243562.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013723243562.29"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1994-11", 
    "datePublishedReg": "1994-11-01", 
    "description": "A 59-year-old man with the diagnosis of endocarditis of the mitral valve due to Streptococcus mitis was treated with penicillin G, gentamicin, and later with clindamycin as inpatient for 3 weeks. Thereafter outpatient therapy with parenteral teicoplanin 3 \u00d7 per week was initiated. After 17 days of teicoplanin treatment he developed severe diarrhea, and stool samples were positive for Clostridium difficile toxin. In addition to the ongoing parenteral therapy with teicoplanin, oral teicoplanin was administered. On the third day of this regimen the diarrhea and other disabling symptoms subsided, and test results for C. difficile toxin became negative. Oral teicoplanin was continued for 10 days and cleared C. difficile effectively after treatment as assessed by consecutive stool cultures (until 60 days thereafter). The parenteral administration of teicoplanin could not prevent the onset of C. difficile associated diarrhea in this patient, who previously had been treated with clindamycin. Thus, the administration of parenteral teicoplanin does not seem to be a treatment option for C. difficile associated diarrhea in patients in which oral therapy is not possible.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf00190753", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1057918", 
        "issn": [
          "0946-2716", 
          "1432-1440"
        ], 
        "name": "Journal of Molecular Medicine", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "72"
      }
    ], 
    "keywords": [
      "oral teicoplanin", 
      "difficile toxin", 
      "consecutive stool cultures", 
      "diagnosis of endocarditis", 
      "Clostridium difficile toxin", 
      "teicoplanin treatment", 
      "parenteral teicoplanin", 
      "intravenous teicoplanin", 
      "parenteral therapy", 
      "oral therapy", 
      "stool cultures", 
      "outpatient therapy", 
      "treatment options", 
      "severe diarrhea", 
      "mitral valve", 
      "stool samples", 
      "diarrhea", 
      "parenteral administration", 
      "Clostridium difficile", 
      "third day", 
      "therapy", 
      "teicoplanin", 
      "penicillin G", 
      "patients", 
      "clindamycin", 
      "administration", 
      "Streptococcus mitis", 
      "weeks", 
      "difficile", 
      "days", 
      "treatment", 
      "toxin", 
      "endocarditis", 
      "symptoms", 
      "gentamicin", 
      "diagnosis", 
      "men", 
      "onset", 
      "options", 
      "valve", 
      "mitis", 
      "test results", 
      "culture", 
      "addition", 
      "samples", 
      "results", 
      "parenteral teicoplanin 3 \u00d7", 
      "teicoplanin 3 \u00d7", 
      "ongoing parenteral therapy"
    ], 
    "name": "Intravenous teicoplanin does not prevent Clostridium difficile associated diarrhea", 
    "pagination": "922-924", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1049116532"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00190753"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7894224"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00190753", 
      "https://app.dimensions.ai/details/publication/pub.1049116532"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:09", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_258.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf00190753"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00190753'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00190753'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00190753'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00190753'


 

This table displays all metadata directly associated to this object as RDF triples.

163 TRIPLES      21 PREDICATES      84 URIs      76 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00190753 schema:about N0c03649c77d743bcb3af17eda2d52eed
2 N1cb22a1e2e0b4c21b091c84ae90b3705
3 N9df46ea63e0e4aaaaf24750130f208a9
4 Nab29f2d37265422da64533c3dc4a370f
5 Nc1d1135ad04c4bf6aaa1e589c685fd0b
6 Nd005802356914f4ba94c634fe4469be0
7 Nf296996ce22443b0814419f9cf1dea17
8 Nf9b306044c0f4676babbab5b4e018258
9 anzsrc-for:03
10 anzsrc-for:0304
11 schema:author Nc6661f115edc497bbe3c1f76884a65cd
12 schema:datePublished 1994-11
13 schema:datePublishedReg 1994-11-01
14 schema:description A 59-year-old man with the diagnosis of endocarditis of the mitral valve due to Streptococcus mitis was treated with penicillin G, gentamicin, and later with clindamycin as inpatient for 3 weeks. Thereafter outpatient therapy with parenteral teicoplanin 3 × per week was initiated. After 17 days of teicoplanin treatment he developed severe diarrhea, and stool samples were positive for Clostridium difficile toxin. In addition to the ongoing parenteral therapy with teicoplanin, oral teicoplanin was administered. On the third day of this regimen the diarrhea and other disabling symptoms subsided, and test results for C. difficile toxin became negative. Oral teicoplanin was continued for 10 days and cleared C. difficile effectively after treatment as assessed by consecutive stool cultures (until 60 days thereafter). The parenteral administration of teicoplanin could not prevent the onset of C. difficile associated diarrhea in this patient, who previously had been treated with clindamycin. Thus, the administration of parenteral teicoplanin does not seem to be a treatment option for C. difficile associated diarrhea in patients in which oral therapy is not possible.
15 schema:genre article
16 schema:inLanguage en
17 schema:isAccessibleForFree false
18 schema:isPartOf N0e73fee09a60484a98e3ea65bd030f17
19 Nff1d13aac0d342e99d643ae9b4fa17cf
20 sg:journal.1057918
21 schema:keywords Clostridium difficile
22 Clostridium difficile toxin
23 Streptococcus mitis
24 addition
25 administration
26 clindamycin
27 consecutive stool cultures
28 culture
29 days
30 diagnosis
31 diagnosis of endocarditis
32 diarrhea
33 difficile
34 difficile toxin
35 endocarditis
36 gentamicin
37 intravenous teicoplanin
38 men
39 mitis
40 mitral valve
41 ongoing parenteral therapy
42 onset
43 options
44 oral teicoplanin
45 oral therapy
46 outpatient therapy
47 parenteral administration
48 parenteral teicoplanin
49 parenteral teicoplanin 3 ×
50 parenteral therapy
51 patients
52 penicillin G
53 results
54 samples
55 severe diarrhea
56 stool cultures
57 stool samples
58 symptoms
59 teicoplanin
60 teicoplanin 3 ×
61 teicoplanin treatment
62 test results
63 therapy
64 third day
65 toxin
66 treatment
67 treatment options
68 valve
69 weeks
70 schema:name Intravenous teicoplanin does not prevent Clostridium difficile associated diarrhea
71 schema:pagination 922-924
72 schema:productId N054229a519ff4cdc9895f9af9dcac19f
73 N6c2665b9190345ff9251066ff06ef6d8
74 N7824317e08ed4f98a33a55550a3b8108
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049116532
76 https://doi.org/10.1007/bf00190753
77 schema:sdDatePublished 2021-12-01T19:09
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher Nb5599cb0820a49ff93b65abf1a68a502
80 schema:url https://doi.org/10.1007/bf00190753
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N054229a519ff4cdc9895f9af9dcac19f schema:name doi
85 schema:value 10.1007/bf00190753
86 rdf:type schema:PropertyValue
87 N0c03649c77d743bcb3af17eda2d52eed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Diarrhea
89 rdf:type schema:DefinedTerm
90 N0e73fee09a60484a98e3ea65bd030f17 schema:volumeNumber 72
91 rdf:type schema:PublicationVolume
92 N1cb22a1e2e0b4c21b091c84ae90b3705 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Clostridium difficile
94 rdf:type schema:DefinedTerm
95 N47a7ae31377a4b968387c3a87eef6bf3 rdf:first sg:person.013723243562.29
96 rdf:rest rdf:nil
97 N6c2665b9190345ff9251066ff06ef6d8 schema:name pubmed_id
98 schema:value 7894224
99 rdf:type schema:PropertyValue
100 N71bcd5872156432baa3da0551ba1dbf4 rdf:first sg:person.014412360064.45
101 rdf:rest N47a7ae31377a4b968387c3a87eef6bf3
102 N7824317e08ed4f98a33a55550a3b8108 schema:name dimensions_id
103 schema:value pub.1049116532
104 rdf:type schema:PropertyValue
105 N9df46ea63e0e4aaaaf24750130f208a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Middle Aged
107 rdf:type schema:DefinedTerm
108 Nab29f2d37265422da64533c3dc4a370f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Injections, Intravenous
110 rdf:type schema:DefinedTerm
111 Nb5599cb0820a49ff93b65abf1a68a502 schema:name Springer Nature - SN SciGraph project
112 rdf:type schema:Organization
113 Nc1d1135ad04c4bf6aaa1e589c685fd0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Male
115 rdf:type schema:DefinedTerm
116 Nc522affeeccb47edaac92b0c11fc154a schema:affiliation grid-institutes:grid.488389.6
117 schema:familyName Etzersdorfer
118 schema:givenName E.
119 rdf:type schema:Person
120 Nc6661f115edc497bbe3c1f76884a65cd rdf:first sg:person.015376635734.33
121 rdf:rest Nf4460581e7a94c9fa0a79d5d2f7c84a0
122 Nd005802356914f4ba94c634fe4469be0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Teicoplanin
124 rdf:type schema:DefinedTerm
125 Nf296996ce22443b0814419f9cf1dea17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Enterocolitis, Pseudomembranous
127 rdf:type schema:DefinedTerm
128 Nf4460581e7a94c9fa0a79d5d2f7c84a0 rdf:first Nc522affeeccb47edaac92b0c11fc154a
129 rdf:rest N71bcd5872156432baa3da0551ba1dbf4
130 Nf9b306044c0f4676babbab5b4e018258 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Humans
132 rdf:type schema:DefinedTerm
133 Nff1d13aac0d342e99d643ae9b4fa17cf schema:issueNumber 11
134 rdf:type schema:PublicationIssue
135 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
136 schema:name Chemical Sciences
137 rdf:type schema:DefinedTerm
138 anzsrc-for:0304 schema:inDefinedTermSet anzsrc-for:
139 schema:name Medicinal and Biomolecular Chemistry
140 rdf:type schema:DefinedTerm
141 sg:journal.1057918 schema:issn 0946-2716
142 1432-1440
143 schema:name Journal of Molecular Medicine
144 schema:publisher Springer Nature
145 rdf:type schema:Periodical
146 sg:person.013723243562.29 schema:affiliation grid-institutes:grid.488389.6
147 schema:familyName Graninger
148 schema:givenName W.
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013723243562.29
150 rdf:type schema:Person
151 sg:person.014412360064.45 schema:affiliation grid-institutes:grid.488389.6
152 schema:familyName Breyer
153 schema:givenName S.
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014412360064.45
155 rdf:type schema:Person
156 sg:person.015376635734.33 schema:affiliation grid-institutes:grid.488389.6
157 schema:familyName Wenisch
158 schema:givenName C.
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015376635734.33
160 rdf:type schema:Person
161 grid-institutes:grid.488389.6 schema:alternateName Abteilung für Infektionen, Innere Medizin I, Universitätsklinik Wien, Währinger Gürtel 18-20, A-1090, Wien, Austria
162 schema:name Abteilung für Infektionen, Innere Medizin I, Universitätsklinik Wien, Währinger Gürtel 18-20, A-1090, Wien, Austria
163 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...