Repeated fluorodeoxyglucose positron emission tomography of the brain in infants with suspected hypoxic-ischaemic brain injury View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-09

AUTHORS

Hanna Suhonen-Polvi, Pentti Kero, Heikki Korvenranta, Ulla Ruotsalainen, Merja Haaparanta, Jörgen Bergman, Olli Simell, Uno Wegelius

ABSTRACT

Positron emission tomography (PET) permits the study of cerebral metabolism in vivo. We performed repeated PET studies with fluorine-18 fluorodeoxyglucose (FDG) as a tracer to measure cerebral glucose metabolism for estimation of neurological prognosis in infants with suspected hypoxic-ischaemic brain injury. Fourteen infants (gestational age 35.3 +/- 4.67 weeks) were examined during the neonatal period (at age 38.4 +/- 2.7 weeks) and again at the age of 3.5 +/- 0.7 months; one further infant was studied only once at the age of 2.5 months. All children also underwent ultrasound examinations. Electroencephalography and computed tomography or magnetic resonance imaging were performed according to their clinical condition and their neurological development has been followed. FDG accumulated most actively in the subcortical areas (thalami, brainstem and cerebellum) and the sensorimotor cortex during the neonatal period. The repeated PET study showed that the uptake of FDG was markedly high and increased in all brain sections of infants with normal development (n = 11), whereas those with delayed development (n = 4) had significantly lower values (P < or = 0.005). More... »

PAGES

759-765

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00180905

DOI

http://dx.doi.org/10.1007/bf00180905

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014316536

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8223769


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