Cytotoxicity of diethyldithiocarbamate in human versus rodent cell lines View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-05

AUTHORS

Justin D. Cohen, H. Ian Robins

ABSTRACT

Diethyldithiocarbamate (DDTC) and other dithiocarbamates are currently receiving attention as potential adjuncts to traditional chemotherapy. In vitro studies with rodent cancer cell lines have consistently shown that DDTC concentrations of 0.1-1.0 micrograms/ml are highly cytotoxic. Paradoxically, however, concentrations of 10-100 micrograms/ml have been significantly less toxic. In the present study, such a 'biphasic' pattern was reproduced when 3 rodent cell lines were exposed for 1 hour to 0.001 to 1000 micrograms DDTC/ml. In contrast, in 7 human cell lines survival decreased steadily with increasing DDTC concentration (in the same dose range) without evidence of a biphasic pattern. These data might have implications for studies in which rodent cell lines are used to model the effects of dithiocarbamates in human tissues. More... »

PAGES

137-142

References to SciGraph publications

  • 1983. Sodium Diethyldithiocarbamate (Imuthiol) and Cancer in BIOLOGICAL RESPONSE MODIFIERS IN HUMAN ONCOLOGY AND IMMUNOLOGY
  • 1954-09. Effect of Dithiocarbamates on Sarcoma Cells and Fibrocytes Cultured In Vitro in BRITISH JOURNAL OF CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00177247

    DOI

    http://dx.doi.org/10.1007/bf00177247

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020392004

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2166719


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