Phase II trial of mitoxantrone in acute lymphocytic leukemia of childhood View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-08

AUTHORS

M. L. Graham, J. Estrada, A. H. Ragab, K. A. Starling, D. Rosen, R. W. Wilkerson

ABSTRACT

Thirty children with refractory acute lymphocytic leukemia (ALL) were treated with mitoxantrone, 8 mg/m2/day, for 5 days. Three children received a second course of the drug 3 to 4 weeks later. All but two patients had received prior anthracycline therapy. There were 2 complete responses, 4 early deaths, and 24 patients with persistent leukemia. Of the 21 patients with circulating blasts at the start of mitoxantrone who did not achieve remission, 16 (76%) had complete clearance of their peripheral blood blasts. Although all patients developed profound neutropenia (less than 100 per mm-3), mucosal and hepatic toxicities were uncommon and mild. Mitoxantrone has moderate activity in childhood ALL and should be considered for further trials in less heavily pretreated patients. More... »

PAGES

263-267

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00176981

DOI

http://dx.doi.org/10.1007/bf00176981

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020397996

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1783526


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child, Preschool", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Administration Schedule", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Evaluation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukocyte Count", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitoxantrone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nausea", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neutrophils", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Platelet Count", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Precursor Cell Lymphoblastic Leukemia-Lymphoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vomiting", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Duke University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.189509.c", 
          "name": [
            "Duke University Medical Center, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Graham", 
        "givenName": "M. L.", 
        "id": "sg:person.01007317253.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007317253.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of South Florida", 
          "id": "https://www.grid.ac/institutes/grid.170693.a", 
          "name": [
            "University of South Florida, Tampa, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Estrada", 
        "givenName": "J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Emory University School of Medicine, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ragab", 
        "givenName": "A. H.", 
        "id": "sg:person.010643352004.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010643352004.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "West Virginia University Hospitals", 
          "id": "https://www.grid.ac/institutes/grid.412950.b", 
          "name": [
            "West Virginia University Medical Center, Charleston, WV, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Starling", 
        "givenName": "K. A.", 
        "id": "sg:person.065570553.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.065570553.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Wichita Community Clinical Oncology Program, Wichita, KS, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rosen", 
        "givenName": "D.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Center of Hawaii", 
          "id": "https://www.grid.ac/institutes/grid.490535.e", 
          "name": [
            "Cancer Center of Hawaii, Honolulu, HI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wilkerson", 
        "givenName": "R. W.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00174171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001218012", 
          "https://doi.org/10.1007/bf00174171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00174171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001218012", 
          "https://doi.org/10.1007/bf00174171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00255899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007294863", 
          "https://doi.org/10.1007/bf00255899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00255899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007294863", 
          "https://doi.org/10.1007/bf00255899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00174170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009605062", 
          "https://doi.org/10.1007/bf00174170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00174170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009605062", 
          "https://doi.org/10.1007/bf00174170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00174169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015026290", 
          "https://doi.org/10.1007/bf00174169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00174169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015026290", 
          "https://doi.org/10.1007/bf00174169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00174163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022277563", 
          "https://doi.org/10.1007/bf00174163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00174163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022277563", 
          "https://doi.org/10.1007/bf00174163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00180193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036298014", 
          "https://doi.org/10.1007/bf00180193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00180193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036298014", 
          "https://doi.org/10.1007/bf00180193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00174174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043680036", 
          "https://doi.org/10.1007/bf00174174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00174174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043680036", 
          "https://doi.org/10.1007/bf00174174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm00195a002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055938382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm00201a012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055938574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078429182", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1988.6.2.308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079657934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079772311", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079953847", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079995163", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079996652", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080125743", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081714815", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081714817", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081992409", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081998186", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1991-08", 
    "datePublishedReg": "1991-08-01", 
    "description": "Thirty children with refractory acute lymphocytic leukemia (ALL) were treated with mitoxantrone, 8 mg/m2/day, for 5 days. Three children received a second course of the drug 3 to 4 weeks later. All but two patients had received prior anthracycline therapy. There were 2 complete responses, 4 early deaths, and 24 patients with persistent leukemia. Of the 21 patients with circulating blasts at the start of mitoxantrone who did not achieve remission, 16 (76%) had complete clearance of their peripheral blood blasts. Although all patients developed profound neutropenia (less than 100 per mm-3), mucosal and hepatic toxicities were uncommon and mild. Mitoxantrone has moderate activity in childhood ALL and should be considered for further trials in less heavily pretreated patients.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf00176981", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2693341", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2693238", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2693331", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1094201", 
        "issn": [
          "0167-6997", 
          "1573-0646"
        ], 
        "name": "Investigational New Drugs", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Phase II trial of mitoxantrone in acute lymphocytic leukemia of childhood", 
    "pagination": "263-267", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00176981"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6130c327f0579c92bfd553af0fefc5669f4665b97eae632adb6b9692fd71ecfa"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1020397996"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8309330"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "1783526"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00176981", 
      "https://app.dimensions.ai/details/publication/pub.1020397996"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T08:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000374_0000000374/records_119720_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF00176981"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00176981'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00176981'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00176981'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00176981'


 

This table displays all metadata directly associated to this object as RDF triples.

242 TRIPLES      21 PREDICATES      65 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00176981 schema:about N0212e85c2ced480285bf33afb44f63ba
2 N034a6b35a25c4e82ae939a5709562b6e
3 N0d759f3a83f443698277cf7b3408b1a4
4 N1099c16988b34951b8193660c8ba23a4
5 N158b364232e44d22ab629df626a82f24
6 N1c905c679c9849ae9801de31148dc619
7 N5925669f670649329191db4a5aba7cd4
8 N5bbc19d797d9441386af731731f006b3
9 N7757ff3f3da64fcbb27629690c06b133
10 N78bd35d1ae984af3a2d1edabff383e1e
11 N9d23ee809b004e9fa0e0e0151d8cb3e0
12 N9dfa954c42ef4b3e9ccbcb1140b24c6a
13 Na1ad6b034831410da047c7f0f96e1c0f
14 Ne36d315b37ac45f1af8b059ae48c887d
15 Ne9a7597880204949a8974e3192b4ce0e
16 Nfb2bac8730bd4bda95843594ba0d1862
17 anzsrc-for:11
18 anzsrc-for:1102
19 schema:author Na76b1f9081eb4846814c62fec73f818a
20 schema:citation sg:pub.10.1007/bf00174163
21 sg:pub.10.1007/bf00174169
22 sg:pub.10.1007/bf00174170
23 sg:pub.10.1007/bf00174171
24 sg:pub.10.1007/bf00174174
25 sg:pub.10.1007/bf00180193
26 sg:pub.10.1007/bf00255899
27 https://app.dimensions.ai/details/publication/pub.1078429182
28 https://app.dimensions.ai/details/publication/pub.1079772311
29 https://app.dimensions.ai/details/publication/pub.1079953847
30 https://app.dimensions.ai/details/publication/pub.1079995163
31 https://app.dimensions.ai/details/publication/pub.1079996652
32 https://app.dimensions.ai/details/publication/pub.1080125743
33 https://app.dimensions.ai/details/publication/pub.1081714815
34 https://app.dimensions.ai/details/publication/pub.1081714817
35 https://app.dimensions.ai/details/publication/pub.1081992409
36 https://app.dimensions.ai/details/publication/pub.1081998186
37 https://doi.org/10.1021/jm00195a002
38 https://doi.org/10.1021/jm00201a012
39 https://doi.org/10.1200/jco.1988.6.2.308
40 schema:datePublished 1991-08
41 schema:datePublishedReg 1991-08-01
42 schema:description Thirty children with refractory acute lymphocytic leukemia (ALL) were treated with mitoxantrone, 8 mg/m2/day, for 5 days. Three children received a second course of the drug 3 to 4 weeks later. All but two patients had received prior anthracycline therapy. There were 2 complete responses, 4 early deaths, and 24 patients with persistent leukemia. Of the 21 patients with circulating blasts at the start of mitoxantrone who did not achieve remission, 16 (76%) had complete clearance of their peripheral blood blasts. Although all patients developed profound neutropenia (less than 100 per mm-3), mucosal and hepatic toxicities were uncommon and mild. Mitoxantrone has moderate activity in childhood ALL and should be considered for further trials in less heavily pretreated patients.
43 schema:genre research_article
44 schema:inLanguage en
45 schema:isAccessibleForFree false
46 schema:isPartOf N9ba40f5a3a9b44b4914543facc3019d5
47 Nfad4d3e5a88845b3aeb41c55486d79cb
48 sg:journal.1094201
49 schema:name Phase II trial of mitoxantrone in acute lymphocytic leukemia of childhood
50 schema:pagination 263-267
51 schema:productId N0e429837beb146cba0481d21d0ee7f91
52 N31d1a158e2404ebab47d3b4c112fb534
53 N3d5378d587b4409f8c4946980025c6b4
54 N5934d9bd401040f3ad5a45fc8540f674
55 Nbc17e201881c484ea4a0bcdeb10f4482
56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020397996
57 https://doi.org/10.1007/bf00176981
58 schema:sdDatePublished 2019-04-15T08:48
59 schema:sdLicense https://scigraph.springernature.com/explorer/license/
60 schema:sdPublisher Nd37375a7357d463da5c21998bf96a740
61 schema:url http://link.springer.com/10.1007/BF00176981
62 sgo:license sg:explorer/license/
63 sgo:sdDataset articles
64 rdf:type schema:ScholarlyArticle
65 N0212e85c2ced480285bf33afb44f63ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Leukocyte Count
67 rdf:type schema:DefinedTerm
68 N034a6b35a25c4e82ae939a5709562b6e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Male
70 rdf:type schema:DefinedTerm
71 N0d759f3a83f443698277cf7b3408b1a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Child
73 rdf:type schema:DefinedTerm
74 N0e429837beb146cba0481d21d0ee7f91 schema:name readcube_id
75 schema:value 6130c327f0579c92bfd553af0fefc5669f4665b97eae632adb6b9692fd71ecfa
76 rdf:type schema:PropertyValue
77 N1099c16988b34951b8193660c8ba23a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Nausea
79 rdf:type schema:DefinedTerm
80 N11ca307e1195439a876079a8de47d454 schema:name Wichita Community Clinical Oncology Program, Wichita, KS, USA
81 rdf:type schema:Organization
82 N158b364232e44d22ab629df626a82f24 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Infant
84 rdf:type schema:DefinedTerm
85 N1c905c679c9849ae9801de31148dc619 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Mitoxantrone
87 rdf:type schema:DefinedTerm
88 N2c528194580b454289d7d0afccef2682 rdf:first Nbd0b3493d6ec48139bf593e74278e628
89 rdf:rest Nf03cf008d0d943549318113e19770558
90 N31d1a158e2404ebab47d3b4c112fb534 schema:name dimensions_id
91 schema:value pub.1020397996
92 rdf:type schema:PropertyValue
93 N3d5378d587b4409f8c4946980025c6b4 schema:name nlm_unique_id
94 schema:value 8309330
95 rdf:type schema:PropertyValue
96 N45ed701b6f1d4816a3a63fd9301e82ea schema:affiliation https://www.grid.ac/institutes/grid.490535.e
97 schema:familyName Wilkerson
98 schema:givenName R. W.
99 rdf:type schema:Person
100 N50d063859eef44d59c0333001ecd572b rdf:first N6966fd8990bb4700a24be468c2db8ae5
101 rdf:rest N9a4e8ba54e65440da98aae56ec545a51
102 N5925669f670649329191db4a5aba7cd4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Vomiting
104 rdf:type schema:DefinedTerm
105 N5934d9bd401040f3ad5a45fc8540f674 schema:name doi
106 schema:value 10.1007/bf00176981
107 rdf:type schema:PropertyValue
108 N5bbc19d797d9441386af731731f006b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Drug Evaluation
110 rdf:type schema:DefinedTerm
111 N6966fd8990bb4700a24be468c2db8ae5 schema:affiliation N11ca307e1195439a876079a8de47d454
112 schema:familyName Rosen
113 schema:givenName D.
114 rdf:type schema:Person
115 N7757ff3f3da64fcbb27629690c06b133 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Neutrophils
117 rdf:type schema:DefinedTerm
118 N78bd35d1ae984af3a2d1edabff383e1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Drug Administration Schedule
120 rdf:type schema:DefinedTerm
121 N9a4e8ba54e65440da98aae56ec545a51 rdf:first N45ed701b6f1d4816a3a63fd9301e82ea
122 rdf:rest rdf:nil
123 N9ba40f5a3a9b44b4914543facc3019d5 schema:volumeNumber 9
124 rdf:type schema:PublicationVolume
125 N9d23ee809b004e9fa0e0e0151d8cb3e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Adolescent
127 rdf:type schema:DefinedTerm
128 N9dfa954c42ef4b3e9ccbcb1140b24c6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Child, Preschool
130 rdf:type schema:DefinedTerm
131 Na1ad6b034831410da047c7f0f96e1c0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Humans
133 rdf:type schema:DefinedTerm
134 Na76b1f9081eb4846814c62fec73f818a rdf:first sg:person.01007317253.27
135 rdf:rest N2c528194580b454289d7d0afccef2682
136 Nbc17e201881c484ea4a0bcdeb10f4482 schema:name pubmed_id
137 schema:value 1783526
138 rdf:type schema:PropertyValue
139 Nbd0b3493d6ec48139bf593e74278e628 schema:affiliation https://www.grid.ac/institutes/grid.170693.a
140 schema:familyName Estrada
141 schema:givenName J.
142 rdf:type schema:Person
143 Nd37375a7357d463da5c21998bf96a740 schema:name Springer Nature - SN SciGraph project
144 rdf:type schema:Organization
145 Ne36d315b37ac45f1af8b059ae48c887d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Platelet Count
147 rdf:type schema:DefinedTerm
148 Ne9a7597880204949a8974e3192b4ce0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Female
150 rdf:type schema:DefinedTerm
151 Nedce5d3701af40a8843bbec22f84f510 rdf:first sg:person.065570553.31
152 rdf:rest N50d063859eef44d59c0333001ecd572b
153 Nf03cf008d0d943549318113e19770558 rdf:first sg:person.010643352004.84
154 rdf:rest Nedce5d3701af40a8843bbec22f84f510
155 Nfad4d3e5a88845b3aeb41c55486d79cb schema:issueNumber 3
156 rdf:type schema:PublicationIssue
157 Nfb2bac8730bd4bda95843594ba0d1862 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Precursor Cell Lymphoblastic Leukemia-Lymphoma
159 rdf:type schema:DefinedTerm
160 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
161 schema:name Medical and Health Sciences
162 rdf:type schema:DefinedTerm
163 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
164 schema:name Cardiorespiratory Medicine and Haematology
165 rdf:type schema:DefinedTerm
166 sg:grant.2693238 http://pending.schema.org/fundedItem sg:pub.10.1007/bf00176981
167 rdf:type schema:MonetaryGrant
168 sg:grant.2693331 http://pending.schema.org/fundedItem sg:pub.10.1007/bf00176981
169 rdf:type schema:MonetaryGrant
170 sg:grant.2693341 http://pending.schema.org/fundedItem sg:pub.10.1007/bf00176981
171 rdf:type schema:MonetaryGrant
172 sg:journal.1094201 schema:issn 0167-6997
173 1573-0646
174 schema:name Investigational New Drugs
175 rdf:type schema:Periodical
176 sg:person.01007317253.27 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
177 schema:familyName Graham
178 schema:givenName M. L.
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007317253.27
180 rdf:type schema:Person
181 sg:person.010643352004.84 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
182 schema:familyName Ragab
183 schema:givenName A. H.
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010643352004.84
185 rdf:type schema:Person
186 sg:person.065570553.31 schema:affiliation https://www.grid.ac/institutes/grid.412950.b
187 schema:familyName Starling
188 schema:givenName K. A.
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.065570553.31
190 rdf:type schema:Person
191 sg:pub.10.1007/bf00174163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022277563
192 https://doi.org/10.1007/bf00174163
193 rdf:type schema:CreativeWork
194 sg:pub.10.1007/bf00174169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015026290
195 https://doi.org/10.1007/bf00174169
196 rdf:type schema:CreativeWork
197 sg:pub.10.1007/bf00174170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009605062
198 https://doi.org/10.1007/bf00174170
199 rdf:type schema:CreativeWork
200 sg:pub.10.1007/bf00174171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001218012
201 https://doi.org/10.1007/bf00174171
202 rdf:type schema:CreativeWork
203 sg:pub.10.1007/bf00174174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043680036
204 https://doi.org/10.1007/bf00174174
205 rdf:type schema:CreativeWork
206 sg:pub.10.1007/bf00180193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036298014
207 https://doi.org/10.1007/bf00180193
208 rdf:type schema:CreativeWork
209 sg:pub.10.1007/bf00255899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007294863
210 https://doi.org/10.1007/bf00255899
211 rdf:type schema:CreativeWork
212 https://app.dimensions.ai/details/publication/pub.1078429182 schema:CreativeWork
213 https://app.dimensions.ai/details/publication/pub.1079772311 schema:CreativeWork
214 https://app.dimensions.ai/details/publication/pub.1079953847 schema:CreativeWork
215 https://app.dimensions.ai/details/publication/pub.1079995163 schema:CreativeWork
216 https://app.dimensions.ai/details/publication/pub.1079996652 schema:CreativeWork
217 https://app.dimensions.ai/details/publication/pub.1080125743 schema:CreativeWork
218 https://app.dimensions.ai/details/publication/pub.1081714815 schema:CreativeWork
219 https://app.dimensions.ai/details/publication/pub.1081714817 schema:CreativeWork
220 https://app.dimensions.ai/details/publication/pub.1081992409 schema:CreativeWork
221 https://app.dimensions.ai/details/publication/pub.1081998186 schema:CreativeWork
222 https://doi.org/10.1021/jm00195a002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055938382
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1021/jm00201a012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055938574
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1200/jco.1988.6.2.308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079657934
227 rdf:type schema:CreativeWork
228 https://www.grid.ac/institutes/grid.170693.a schema:alternateName University of South Florida
229 schema:name University of South Florida, Tampa, FL, USA
230 rdf:type schema:Organization
231 https://www.grid.ac/institutes/grid.189509.c schema:alternateName Duke University Hospital
232 schema:name Duke University Medical Center, Durham, NC, USA
233 rdf:type schema:Organization
234 https://www.grid.ac/institutes/grid.189967.8 schema:alternateName Emory University
235 schema:name Emory University School of Medicine, Atlanta, GA, USA
236 rdf:type schema:Organization
237 https://www.grid.ac/institutes/grid.412950.b schema:alternateName West Virginia University Hospitals
238 schema:name West Virginia University Medical Center, Charleston, WV, USA
239 rdf:type schema:Organization
240 https://www.grid.ac/institutes/grid.490535.e schema:alternateName Cancer Center of Hawaii
241 schema:name Cancer Center of Hawaii, Honolulu, HI, USA
242 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...