Experimental and clinical studies on the absorption and toxicity of cerium nitrate View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-09

AUTHORS

W. Raffoul, B. Winistörfer, C. Oppikofer, V. Mirkovitch, S. Krupp, R. Chioléro

ABSTRACT

In this publication we present the results of three studies concerning the toxicity and absorption of cerium. In the first experimental study in rats, following the application of a 2.2% solution of cerium nitrate on dorsal wounds for five weeks, delayed healing was demonstrated and histological examination revealed richly vascularized granulation tissue in which microcalcifications and foreign-body type giant cells were found. A high concentration of cerium was found in the liver. The second experimental study employing rat enterocytes demonstrated an immediate cellular toxicity after exposure to a 2.2% cerium nitrate solution. Correction of pH and/or osmolarity did not play a protective role. In the clinical evaluation, significant levels of cerium were found in six blood samples and four urinary specimens, following the application of a 2.2% cerium nitrate solution on burn wounds. Liver biopsies were performed in two cases. There were no abnormal histological findings, but cerium levels were elevated. More... »

PAGES

180-185

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00175681

DOI

http://dx.doi.org/10.1007/bf00175681

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048964033


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