Toxicity trials of amsacrine (AMSA) and etoposide +/− azacitidine (AZ) in childhood acute non-lymphocytic leukemia (ANLL): a pilot study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-05

AUTHORS

C. Philip Steuber, Tate Holbrook, Bruce Camitta, Vita J. Land, Charles Sexauer, Jeffrey Krischer

ABSTRACT

Recurrent or induction therapy-resistant ANLL carries a grave prognosis. The combination of AMSA at 100 mg/M2 daily for 5 days and etoposide at 200 mg/M2 daily for the first 3 days of therapy was given to 40 patients with refractory ANLL. An additional 17 patients received those two agents plus azacitidine at a dosage of 250 mg/M2 on days 4 and 5. All three drugs were given as one-hour infusions. All patients had normal electrolyte determinations daily and were on cardiac monitors during the period of drug administration. No arrhythmias were detected in 522 doses of AMSA. Toxicities observed were primarily related to myelosuppression. Forty-nine of the 57 patients required hospitalization for suspected or proven infection. Nausea/vomiting and mucositis were the next most commonly occurring toxicities. Responses were seen in 22 patients. More... »

PAGES

181-184

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00175085

DOI

http://dx.doi.org/10.1007/bf00175085

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022698834

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1714886


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