Lack of circadian rhythm in plasma levels of 3,4-dihydroxyphenylethyleneglycol in healthy human subjects View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-12

AUTHORS

Trevor Dennis, Chawki Benkelfat, Yvan Touitou, André Auzeby, Marie-France Poirier, Bernard Scatton, Henri Lôo

ABSTRACT

In order to investigate the possible existence of a circadian rhythm in plasma free and sulfate-conjugated 3,4-dihydroxyphenylethyleneglycol (DOPEG), the plasma levels of this metabolite (and for comparison, of melatonin and cortisol) were measured in seven healthy volunteers at 4-h intervals over a period of 24 h. Plasma concentrations of melatonin and cortisol showed distinct diurnal variations with acrophases at 2.5 h and 8.5 h, respectively. In contrast, plasma free DOPEG levels were relatively stable over the 24-h period studied. Sulfate-conjugated and free + sulfate-conjugated DOPEG levels showed a slight, non-significant increase in the early afternoon. These results indicate that in contrast to plasma 3-methoxy 4-hydroxyphenylethyleneglycol, plasma free and conjugated DOPEG levels do not exhibit a circadian rhythm. More... »

PAGES

471-474

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00174063

DOI

http://dx.doi.org/10.1007/bf00174063

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036670337

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3101103


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177 schema:name Biology Department, Laboratoires d'Etudes et de Recherches Synthélabo (L.E.R.S.), 31 avenue Paul Vaillant-Couturier, 92220, Bagneux, France
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179 grid-institutes:grid.462844.8 schema:alternateName Department of Biochemistry, Faculté de Médecine Pitié-Salpétrière, 91 boulevard de l'Hôpital, 75634, Paris, France
180 schema:name Department of Biochemistry, Faculté de Médecine Pitié-Salpétrière, 91 boulevard de l'Hôpital, 75634, Paris, France
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