Effect of topically applied oxymetazoline on tear volume and tear flow in humans View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-03

AUTHORS

Martin J. Göbbels, Christa Achten, Manfred Spitznas

ABSTRACT

Vasoconstrictive, alpha-sympathicomimetic eye drops are ophthalmic drugs that are extensively used. However, patients often complain of typical dry eye symptoms, especially after long-lasting application of such eye drops. In the present study, the effect of sympathicomimetic eye drops (0.026% oxymetazoline) on the tear volume and tear flow of 38 healthy individuals was determined quantitatively by means of objective fluorophotometry. Both tear volume and tear flow were found to be significantly (P less than 0.001) decreased up to 6 h after instillation, reaching a minimum 90 min after application (tear volume: -63%; tear flow: -71%). Thus, alpha-sympathicomimetic eye drops containing 0.026% oxymetazoline lead to a marked and protracted decrease in tear volume and tear flow. After frequent or long-lasting application, this fact may be responsible for severe dry eye conditions. More... »

PAGES

147-149

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00170547

DOI

http://dx.doi.org/10.1007/bf00170547

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001774268

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2044975


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