Toxicity evaluation of dihydroxyanthracenedione (DHAD) in combination with cytosine arabinoside (Ara-C) View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-12

AUTHORS

C. Philip Steuber, Vita J. Land, Curt I. Civin, Abdel H. Ragab, Jeffrey Krischer, Teresa J. Vietti

ABSTRACT

To determine optimal dosage, Dihydroxyanthracenedione (DHAD) was given once daily for 3 days at dosage levels of 6, 7, 8, and 10 mg/m2 in combination with a 7-day continuous infusion of cytosine arabinoside (Ara-C). Nineteen of 20 children with leukemia who received these agents developed fever requiring hospitalization. There were 4 deaths-2 due to proven infection. One patient developed nonfatal cardiotoxicity. No other significant toxicity was noted. Responses were seen in 7 of 20 patients. The recommended DHAD dosage was 8 mg/m2/day when given in combination with Ara-C. More... »

PAGES

379-382

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00169979

DOI

http://dx.doi.org/10.1007/bf00169979

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009536019

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3481363


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