Brain uptake and CNS levels of 1-(2-chloroethyl)-1-nitroso-3-(2-hydroxyethyl)urea (HECNU) View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-12

AUTHORS

C. Unger, H. Eibl, J. Engel, G. A. Nagel, G. Eisenbrand

ABSTRACT

The uptake of 14C-labeled 1-(2-chloroethyl)-1-nitroso-3-(2-hydroxyethyl)urea (HECNU) into the brain was investigated in the rat after intracarotid injection according to the method of OLDENDORF, as well as in cisternal cerebrospinal fluid obtained by suboccipital puncture after i.v. injection of the drug. The brain uptake index was 31.9 +/- 2.9%. Cerebrospinal fluid/blood quotients after i.v. injection were 0.82 at 10 min and 1.10 at 60 min. The results of both methods clearly show that HECNU, in spite of its hydrophilic property, easily penetrates the blood-brain barrier. More... »

PAGES

361-364

References to SciGraph publications

  • 1985-06. Blut-Hirnschranke und Penetration von Zytostatika in JOURNAL OF MOLECULAR MEDICINE
  • 1986-09. Aminoglutethimide in INVESTIGATIONAL NEW DRUGS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00169975

    DOI

    http://dx.doi.org/10.1007/bf00169975

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1017065542

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3436741


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