The vasodilator action of parathyroid hormone fragments on isolated perfused rat kidney View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1989-08

AUTHORS

Marie-José Musso, Mariette Barthehnebs, Jean-Louis Imbs, Martin Plante, Claude Bollack, Jean-Jacques Helwig

ABSTRACT

The renal vasodilator responses to various fragments of PTH were quantified on a model of isolated perfused rat kidney (IPK), under non-filtering conditions. The 1–34 fragment of bovine PTH, its Nle analogue and rat PTH, injected in sequential cumulative doses, caused concentration-dependent vasodilatation in the vasculature of the IPK which was preconstricted with prostaglandin F2α. The EC50 of PTH for renal vasodilatation ranged from 1 to 2 nM for all PTH fragments and maximum vasodilatation ranged from 33 to 41% of the maximum vasodilatation induced by papaverine. Renal vasodilatation was not related to prostaglandin release since similar vasodilatation occurred after the inhibition of prostaglandin synthesis with indomethacin. When PTH was administered in single bolus injections, using a separate kidney for each hormone concentration, rather than repeated injections into the same kidney, higher maximum vasodilatations were obtained (64%). These results most likely reflected tachyphylaxis of the renal vasculature to PTH occurring after repeated exposure of a single kidney to the hormone. The antagonist analogue [Nle8,18 Tyr34]-bPTH-(3–34)A shifted the concentration-related response curve to the right, indicating that the renal vasodilator response to rPTH-(1–34) involved specific vascular receptors. More... »

PAGES

246-251

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00168976

DOI

http://dx.doi.org/10.1007/bf00168976

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007872478

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2812037


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