Catecholamine release in the locus coeruleus is modified by experimentally induced changes in haemodynamics View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-01

AUTHORS

N. Singewald, A. Philippu

ABSTRACT

The involvement of catecholaminergic neurons of the locus coeruleus in central cardiovascular control was investigated in the anaesthetized cat. Push-pull cannulae were bilaterally inserted into the LC and the release of noradrenaline and dopamine was determined radioenzymatically in the superfusate. The effects of experimentally induced changes in blood volume and vascular resistance on catecholamine release in the locus coeruleus were studied.Hypervolaemia strongly inhibited the release of noradrenaline in the locus coeruleus. Intravenous infusion of noradrenaline (5 μg·kg−1·min−1) elicited a pronounced pressor response which was also associated with a decrease in the release of noradrenaline in the locus coeruleus. Conversely, a fall of blood pressure caused by a controlled haemorrhage enhanced the release of noradrenaline. A profound fall in blood pressure caused by infusion of nitroprusside (8 μg·kg−1·min−1) did not modify the release rate of noradrenaline. Dopamine release rate was not significantly influenced by these cardiovascular alterations.The results demonstrate that increases in blood pressure elicited by vascular constriction or hypervolaemia inhibit the release of noradrenaline in the locus coeruleus. Decreases in blood pressure elicited by hypovolaemia enhance the release of noradrenaline, but lowering blood pressure by vasodilatation is ineffective. Hence, the release of endogenous noradrenaline in the locus coeruleus is responsive to haemodynamic signals, thus supporting the suggested integrative role of the locus coeruleus in central cardiovascular control. More... »

PAGES

21-27

References to SciGraph publications

  • 1977-03. Release of dopamine in vivo from cat substantia nigra in NATURE
  • 1992-02. Blood pressure changes modify the release rates of catecholamines in the intermediate nucleus of the solitary tract in NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY
  • 1989. Catecholamines in the Central Nervous System in CATECHOLAMINES II
  • 1984-06. Nucleus locus coeruleus: Evidence for α1-adrenoceptor mediated hypotension in the cat in NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY
  • 1979-08. In vivo release of endogenous catecholamines in the hypothalamus in NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY
  • 1989-03. Pattern of catecholamine release in the nucleus tractus solitarii of the cat in NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY
  • 1991. Interaction of Arterial and Cardiopulmonary Reflexes in BARORECEPTOR REFLEXES
  • 1973-06. Reduced pressor responses to stimulation of the locus coeruleus after lesion of the posterior hypothalamus in NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY
  • 1991-02. Release of endogenous catecholamines in two different regions of the nucleus of the solitary tract as influenced by carotid occlusion in NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY
  • 1973-06. Superfusion of the hypothalamus with gamma-aminobutyric acid in NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY
  • 1988. Regulation of blood pressure by central neurotransmitters and neuropeptides in REVIEWS OF PHYSIOLOGY, BIOCHEMISTRY AND PHARMACOLOGY, VOLUME 111
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00168767

    DOI

    http://dx.doi.org/10.1007/bf00168767

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1042251210

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8446180


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