Xylose fermentation by Saccharomyces cerevisiae View Full Text


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Article Info

DATE

1993-03

AUTHORS

Peter Kötter, Michael Ciriacy

ABSTRACT

We have performed a comparative study of xylose utilization in Saccharomyces cerevisiae transformants expressing two key enzymes in xylose metabolism, xylose reductase (XR) and xylitol dehydrogenase (XDH), and in a prototypic xylose-utilizing yeast, Pichia stipitis. In the absence of respiration (see text), baker's yeast cells convert half of the xylose to xylitol and ethanol, whereas P. stipilis cells display rather a homofermentative conversion of xylose to ethanol. Xylitol production by baker's yeast is interpreted as a result of the dual cofactor dependence of the XR and the generation of NADPH by the pentose phosphate pathway. Further limitations of xylose utilization in S. cerevisiae cells are very likely caused by an insufficient capacity of the non-oxidative pentose phosphate pathway, as indicated by accumulation of sedoheptulose-7-phosphate and the absence of fructose-1,6-bisphosphate and pyruvate accumulation. By contrast, uptake at high substrate concentrations probably does not limit xylose conversion in S. cerevisiae XYL1/XYL2 transformants. More... »

PAGES

776-783

References to SciGraph publications

  • 1974-12. Regulatory properties of the constitutive hexose transport in saccharomyces cerevisiae in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 1988-05. An investigation of d-{1-13C} xylose metabolism in Pichia stipitis under aerobic and anaerobic conditions in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 1984-04. NADH-linked aldose reductase: the key to anaerobic alcoholic fermentation of xylose by yeasts in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 1981. Conversion of hemicellulose carbohydrates in BIOENERGY
  • 1991-04. Xylitol production from D-xylose byCandida guillermondii: Fermentation behaviour in BIOTECHNOLOGY LETTERS
  • 1989-05. Regulated overproduction of α-amylase by transformation of the amylolytic yeast Schwanniomyces occidentalis in CURRENT GENETICS
  • 1989-04. The fermentation of xylose —an analysis of the expression of Bacillus and Actinoplanes xylose isomerase genes in yeast in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 1988-09. Xylose fermentation by yeasts in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 1988-02. Transport of xylose and glucose in the xylose-fermenting yeast Pichia stipitis in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 1990-12. Isolation and characterization of the Pichia stipitis xylitol dehydrogenase gene, XYL2, and construction of a xylose-utilizing Saccharomyces cerevisiae transformant in CURRENT GENETICS
  • 1984-06. Xylose fermentation by yeasts in BIOTECHNOLOGY LETTERS
  • 1985-08. Utilization of formate as an additional energy source by glucose-limited chemostat cultures ofCandida utilis CBS 621 andSaccharomyces cerevisiae CBS 8066 in ARCHIVES OF MICROBIOLOGY
  • 1985-06. Comparative evaluation of ethanol production by xylose-fermenting yeasts presented high xylose concentrations in BIOTECHNOLOGY LETTERS
  • 1983. Utilization of xylose by bacteria, yeasts, and fungi in PENTOSES AND LIGNIN
  • Journal

    TITLE

    Applied Microbiology and Biotechnology

    ISSUE

    6

    VOLUME

    38

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00167144

    DOI

    http://dx.doi.org/10.1007/bf00167144

    DIMENSIONS

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