The cytosolic pathway of l-malic acid synthesis in Saccharomyces cerevisiae: the role of fumarase View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-11

AUTHORS

O. Pines, S. Even-Ram, N. Elnathan, E. Battat, O. Aharonov, D. Gibson, I. Goldberg

ABSTRACT

Saccharomyces cerevisiae accumulates L-malic acid but not only minute amounts of fumaric acid. A 13C-nuclear magnetic resonance study following the label from glucose to L-malic acid indicates that the L-malic acid is synthesized from pyruvic acid via oxaloacetic acid. From this, and from previously published studies, we conclude that a cytosolic reductive pathway leading from pyruvic acid via oxaloacetic acid to L-malic acid is responsible for the L-malic acid production in yeast. The non-production of fumaric acid can be explained by the conclusion that, in the cell, cytosolic fumarase catalyzes the conversion of fumaric acid to L-malic but not the reverse. This conclusion is based on the following findings. (a) The cytosolic enzyme exhibits a 17-fold higher affinity towards fumaric acid than towards L-malic acid; the Km for L-malic acid is very high indicating that L-malic acid is not an in vivo substrate of the enzyme. (b) Overexpression of cytosolic fumarase does not cause accumulation of fumaric acid (but rather more L-malic acid). (c) According to 13C NMR studies there is no interconversion of cytosolic L-malic and fumaric acids. More... »

PAGES

393-399

References to SciGraph publications

  • 1989-02. Malic acid accumulation by Aspergillus flavus in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 1988-02. Formation of l(-)malate by Saccharomyces cerevisiae during fermentation in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 1977-05. Location of three key enzymes of gluconeogenesis in baker's yeast in ARCHIVES OF MICROBIOLOGY
  • 1988-03. Malic acid accumulation by Aspergillus flavus in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 1984-06. Malic acid production and consumption by selected of Saccharomyces cerevisiae under anaerobic and aerobic conditions in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/bf00166235

    DOI

    http://dx.doi.org/10.1007/bf00166235

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8987728


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