C-myc oncogene expression in ocular melanomas View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-07

AUTHORS

Janice A. Royds, R. Michael Sharrard, M. Andrew Parsons, John Lawry, Robert Rees, David Cottam, Bart Wagner, Ian G. Rennie

ABSTRACT

We have investigated the expression of c-myc in 24 ocular melanomas by immunohistochemistry, using two monoclonal antibodies raised against a midsequence portion of the c-myc product (6E10) and against the C-terminus (9E10). The results were compared with other putative prognostic factors, including tumour size, cell type, proliferation index (determined by flow cytometry), and ploidy, as well as immunohistochemical staining for HMB-45 and S-100 antigens. Staining, often focal, for c-myc was found in both the nucleus and the cytoplasm of a proportion of the cells in most tumours studied. Total cell staining for myc protein correlated with proliferative index in diploid tumours; seven out of nine aneuploid and mixed aneuploid/diploid cells showed strong staining in at least one cellular compartment. A positive correlation with myc expression was also found for HMB-45 staining, but not for cell type or staining for S-100. The results support the hypothesis that myc protein is involved in cellular proliferation in uveal melanomas and indicate that immunohistochemistry for myc antigen may be a useful prognostic marker in these tumours. More... »

PAGES

366-371

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00165947

DOI

http://dx.doi.org/10.1007/bf00165947

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034104686

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1505770


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