Ixodid tick salivary gland extracts inhibit production of lipopolysaccharide-induced mRNA of several different human cytokines View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-11

AUTHORS

Norbert Fuchsberger, Masakazu Kita, Valeria Hajnicka, Jiro Imanishi, Milan Labuda, Patricia A. Nuttall

ABSTRACT

Extracts prepared from the salivary glands (SGE) of partially fed adult female Rhipicephalus appendiculatus ticks reduced the expression by human peripheral blood leukocytes 9PBLs) of lipopolysaccharide (LPS)-stimulated cytokine mRNA. Treatment with SGE had no obvious effect on cytokine mRNA production when compared with untreated PBLs. LPS treatment induced or increased mRNA production for IFN alpha, TNF-alpha, IL-1 alpha, IL-1 beta, IL-5, IL-6, IL-7 and IL-8. All the LPS-stimulated cytokine mRNAs were reduced when treated with a mixture of LPS and SGE. The results indicate the potential of ticks in modulating the cytokine network of their vertebrate hosts, possibly to facilitate blood feeding. More... »

PAGES

671-676

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00145255

DOI

http://dx.doi.org/10.1007/bf00145255

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021336036

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8556960


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