Effect of ester moiety of substrates on enantioselectivity of protease catalysis in organic media View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-12

AUTHORS

Katsuhiro Kawashiro, Hideki Sugahara, Tomoya Tsukioka, Shigeru Sugiyama, Hiromu Hayashi

ABSTRACT

The α-chymotrypsin-catalyzed transesterification between a racemic JV-trifluoroacetyl-phenylalanine ester and 1-propanol, was carried out in organic media. Although activation of the substrate by introducing electron-withdrawing group to the ester moiety enhanced the rate of reaction, it decreased enantioselectivity at the same time. In the instance of subtilisin Carlsberg, inversion of the L-specificity was observed. More... »

PAGES

1381-1386

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00129339

DOI

http://dx.doi.org/10.1007/bf00129339

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032253607


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