Effects of water content on the enantioselectivity of α-chymotrypsin catalysis in organic media View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-11

AUTHORS

Katsuhiro Kawashiro, Hideki Sugahara, Sigeru Sugiyama, Hiromu Hayashi

ABSTRACT

The α-chymotrypsin-catalyzed transesterification between N-trifluoroacetyl-DL-phenylalanine trifluoroethyl ester and 1-propanol was carried out in a variety of organic solvents. The addition of small quantities of water enhanced both the rate of reaction and enantioselectivity. A high enantioselectivity was achieved in ethyl acetate (E = 120), diethyl ether (86), or acetonitrile (60). The competing hydrolysis became significant at water content higher than 0.5% (w/w). More... »

PAGES

1161-1166

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00128378

DOI

http://dx.doi.org/10.1007/bf00128378

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012876060


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