Oncogenic regulation and function of keratins 8 and 18 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-12

AUTHORS

Robert G. Oshima, Hélène Baribault, Carlos Caulín

ABSTRACT

Keratin 8 (K8) and keratin 18 (K18) are the most common and characteristic members of the large intermediate filament gene family expressed in ‘simple’ or single layer epithelial tissues of the body. Their persistent expression in tumor cells derived from these epithelia has led to the wide spread use of keratin monoclonal antibodies as aids in the detection and identification of carcinomas. Oncogenes which activateras signal transduction pathways stimulate expression of the K18 gene through transcription factors including members of the AP-1 (jun and fos) and ETS families. The persistent expression of K8 and K18 may reflect the integrated transcriptional activation of such transcription factors and, in the cases of ectopic expression, an escape from the suppressive epigenetic mechanisms of DNA methylation and chromatin condensation. Comparison of the mechanisms of transcriptional control of K18 expression with expression patterns documented in both normal and pathological conditions leads to the proposal that persistent K8 and K18 expression is a reflection of the action of multiple different oncogenes converging on the nucleus through a limited number of transcription factors to then influence the expression of a large number of genes including these keratins. Furthermore, correlation of various tumor cell characteristics including invasive behavior and drug sensitivity with K8 and K18 expression has stimulated consideration of the possible functions of these proteins in both normal development and in tumorigenesis. Recent developments in the analysis of the functions of these intermediate filament proteins provide new insights into diverse functions influenced by K8 and K18. More... »

PAGES

445-471

References to SciGraph publications

  • 1986-07. Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis in NATURE
  • 1984-10. Differentiation of F9 teratocarcinoma stem cells after transfer of c-fos proto-oncogenes in NATURE
  • 1996-04. A new pattern for helix–turn–helix recognition revealed by the PU.l ETS–domain–DNA complex in NATURE
  • 1988-05. Concerted gene duplications in the two keratin gene families in JOURNAL OF MOLECULAR EVOLUTION
  • 1993-09. c-Jun is essential for normal mouse development and hepatogenesis in NATURE
  • 1992-06. Function of maternal cytokeratin in Xenopus development in NATURE
  • 1980-01-17. Intermediate filaments as mechanical integrators of cellular space in NATURE
  • 1994. Monoclonal Antibody M3 Used in Tissue Polypeptide–Specific Antigen Assay for the Quantification of Tissue Polypeptide Antigen Recognizes Keratin 18 in TUMOR BIOLOGY
  • 1994-08. The ETS domain protein Pointed-P2 is a target of MAP kinase in the Sevenless signal transduction pathway in NATURE
  • 1988-11. Cytoskeletons of retinal pigment epithelial cells: Interspecies differences of expression patterns indicate independence of cell function from the specific complement of cytoskeletal proteins in CELL AND TISSUE RESEARCH
  • 1996-06. Genetic modification of heterochromatic association and nuclear organization in Drosophila in NATURE
  • 1984-02. Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas in NATURE
  • 1985-04-01. Keratinocytes blocked in phorbol ester-responsive early stage of terminal differentiation by sarcoma viruses in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00054012

    DOI

    http://dx.doi.org/10.1007/bf00054012

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004733785

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9034603


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