Morphotypic plasticity in vitro and in nude mice of epithelial mouse mammary cells (NMuMG) displaying an epithelioid (e) or a ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-05

AUTHORS

Caroline Van den Broecke, Kris Vleminckx, Georges De Bruyne, Leen Van Hoorde, Luc Vakaet, Frans Van Roy, Marc Mareel

ABSTRACT

Transition from an epithelioid (e-) to a fibroblastic (f-) morphotype marks invasiveness in clinical and experimental cancer. To understand better the factors influencing such transitions, we have subcloned and manipulated mouse mammary gland (NMuMG) cell cultures and compared the invasive phenotype of multiple subclones in vitro and in vivo. Cell lines with an e-morphotype expressed E-cadherin homogeneously and were not invasive in vitro. Cells with an f-morphotype were E-cadherin-negative and became fully invasive in vitro upon expression of the ras oncogene. Invasive tumors were produced in node mice after subcutaneous injection of e-type or f-type cells. These tumors showed cystic, glandular and undifferentiated structures. Tumors from f-type cells were E-cadherin-negative whereas e-type tumors stained heterogeneously in immunohistochemical preparations. Our observations demonstrate the impact of the micro-ecosystem on the invasive phenotype, with in vivo downregulation of E-cadherin and stimulation of the e- to f-morphotype transition. More... »

PAGES

282-296

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00053902

DOI

http://dx.doi.org/10.1007/bf00053902

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033501251

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8674283


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