In vivo therapeutic effects of interleukin-12 against highly metastatic residual lymphoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-05

AUTHORS

David J. Verbik, Warren W. Stinson, Michael J. Brunda, Anne Kessingert, Shantaram S. Joshi

ABSTRACT

Despite considerable advancement in anticancer therapy, minimal residual disease (MRD) is still a major problem in the clinical management of cancer, including lymphoma. In this report, we have studied the antitumor effects of interleukin-12 (IL-12) against an aggressive liver metastatic murine RAW117-H10 lymphoma. Our results using three different doses of IL-12 (0.175, 0.35 and 0.7 micrograms/mouse) showed that a 0.35 micrograms dose is the most efficacious against lymphoma grown in intact mice. Furthermore, we have evaluated the therapeutic effects of IL-12 against residual lymphoma in a transplantation setting. BALB/c mice were treated with high-dose therapy (HDT) and transplanted with syngeneic bone marrow cells added with a known number of RAW117-H10 lymphoma cells to mimic the clinical situation of MRD. The mice were then treated with IL-12 (0.25 micrograms/mouse/day) alone or IL-12 plus activated cytotoxic effector cells. Our results showed that IL-12 had a significant (P < 0.05) antitumor therapeutic effect against liver metastatic lymphoma grown in intact mice as well as in lymphoma-bearing mice treated with HDT followed by stem cell transplantation as determined by survival period. The therapeutic effect of IL-12 was also demonstrated by a very significant decrease (P < 0.05) in the tumor burden in livers from the IL-12-treated mice. Mice that were treated with IL-12 following HDT and hematopoietic stem cell transplantation had a significant decrease in circulating white blood cells (P < 0.05), a significant increase in spleen weight and cellularity (P < 0.05), and hematopoietic progenitor cells (P < 0.05), a significant increase in the number of splenocytes expressing IL-2 alpha-chain receptor (P < 0.05), and an increase in the frequency of natural killer cells in their spleens. These studies suggest that cytokines such as IL-12 may have the potential to mediate antitumor effects against residual lymphoma without compromising lymphohematopoietic recovery. More... »

PAGES

219-229

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00053895

DOI

http://dx.doi.org/10.1007/bf00053895

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013328260

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8674276


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Marrow Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoiesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cell Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunophenotyping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-12", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoma, B-Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm, Residual", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organ Size", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spleen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Nebraska Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.266813.8", 
          "name": [
            "Departments of Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Verbik", 
        "givenName": "David J.", 
        "id": "sg:person.0613050014.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613050014.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nebraska Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.266813.8", 
          "name": [
            "Departments of Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stinson", 
        "givenName": "Warren W.", 
        "id": "sg:person.01271073640.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271073640.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "Department of OncologyDepartment of OncologyDepartment of Oncology, Hoffmann-La Roche Inc., NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brunda", 
        "givenName": "Michael J.", 
        "id": "sg:person.01135506727.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135506727.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nebraska Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.266813.8", 
          "name": [
            "Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kessingert", 
        "givenName": "Anne", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nebraska Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.266813.8", 
          "name": [
            "Departments of Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Joshi", 
        "givenName": "Shantaram S.", 
        "id": "sg:person.07355130657.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07355130657.98"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1084/jem.159.2.495", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013352472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00915477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013786924", 
          "https://doi.org/10.1007/bf00915477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0008-8749(92)90011-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013827432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.87.17.6808", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014530928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.iy.13.040195.001343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015038538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.178.4.1223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019000723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198704093161501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029831566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.170.3.827", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035451194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.178.2.413", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050103182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/intimm/6.1.157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059712008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7904381", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062650591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.7.2.205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071517482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075969826", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1990.8.4.638", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078644595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078834524", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/61.6.1499", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079407578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079447846", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0889-8588(18)30598-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079527656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079833434", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080018650", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082424203", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082466962", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082472515", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082482166", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082561246", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082562872", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082563636", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082570108", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082570150", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082650029", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082790842", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083347496", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1996-05", 
    "datePublishedReg": "1996-05-01", 
    "description": "Despite considerable advancement in anticancer therapy, minimal residual disease (MRD) is still a major problem in the clinical management of cancer, including lymphoma. In this report, we have studied the antitumor effects of interleukin-12 (IL-12) against an aggressive liver metastatic murine RAW117-H10 lymphoma. Our results using three different doses of IL-12 (0.175, 0.35 and 0.7 micrograms/mouse) showed that a 0.35 micrograms dose is the most efficacious against lymphoma grown in intact mice. Furthermore, we have evaluated the therapeutic effects of IL-12 against residual lymphoma in a transplantation setting. BALB/c mice were treated with high-dose therapy (HDT) and transplanted with syngeneic bone marrow cells added with a known number of RAW117-H10 lymphoma cells to mimic the clinical situation of MRD. The mice were then treated with IL-12 (0.25 micrograms/mouse/day) alone or IL-12 plus activated cytotoxic effector cells. Our results showed that IL-12 had a significant (P < 0.05) antitumor therapeutic effect against liver metastatic lymphoma grown in intact mice as well as in lymphoma-bearing mice treated with HDT followed by stem cell transplantation as determined by survival period. The therapeutic effect of IL-12 was also demonstrated by a very significant decrease (P < 0.05) in the tumor burden in livers from the IL-12-treated mice. Mice that were treated with IL-12 following HDT and hematopoietic stem cell transplantation had a significant decrease in circulating white blood cells (P < 0.05), a significant increase in spleen weight and cellularity (P < 0.05), and hematopoietic progenitor cells (P < 0.05), a significant increase in the number of splenocytes expressing IL-2 alpha-chain receptor (P < 0.05), and an increase in the frequency of natural killer cells in their spleens. These studies suggest that cytokines such as IL-12 may have the potential to mediate antitumor effects against residual lymphoma without compromising lymphohematopoietic recovery.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf00053895", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1094856", 
        "issn": [
          "0262-0898", 
          "1573-7276"
        ], 
        "name": "Clinical & Experimental Metastasis", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "In vivo therapeutic effects of interleukin-12 against highly metastatic residual lymphoma", 
    "pagination": "219-229", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3f7e1c8d9bb89a342683763afc3e2cad0db18b2525b0c07d5e333a9dc258b924"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8674276"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8409970"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00053895"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1013328260"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00053895", 
      "https://app.dimensions.ai/details/publication/pub.1013328260"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:53", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000487.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF00053895"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00053895'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00053895'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00053895'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00053895'


 

This table displays all metadata directly associated to this object as RDF triples.

264 TRIPLES      21 PREDICATES      82 URIs      42 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00053895 schema:about N04966b3801b44c80abae3a67f683ee70
2 N0a7ea7deac48449bbcc32d65c60fb1e0
3 N0f7043638c544328a2ff584eceb7699a
4 N1265cda33ae542029b9ad8cac099d153
5 N3899ca18335d4ce694165598b2971660
6 N43fe9b14137b4d558ae16e9d25e58575
7 N4e6b9427fa864933bae3473d5150bc2c
8 N51545c34e6274788939c0bbeadde5519
9 N5c87d811c81747c98170907df4625f7c
10 N822f1bebb8ad48d2ae341eee8030ffc2
11 Na005656e2ad84aabb608b1d38657b560
12 Nb0b0bbf746e84059ada2b6f06d3d03c4
13 Nb557c5e3f74142659ae6cd2571f05f66
14 Nc07841fb2f044404a8bab55a085c4b25
15 Nc57b53086af1485a8701d2186e24d60b
16 Ndbfa60861f734c6586f77a6ad0d8dd72
17 Ndc1e004edfeb41a79992c07f0bccc147
18 Ne6a5589b94694b0d980f7a221d05c0d6
19 Ne7f44d0828d5422aae71cedfad17d041
20 Nf4857c8526914844b195c7e2ba71237c
21 Nfcfda802e8f941caa9f6282fe0055b09
22 anzsrc-for:11
23 anzsrc-for:1107
24 schema:author Ne5a13f38153f49fb847e7bd64601b305
25 schema:citation sg:pub.10.1007/bf00915477
26 https://app.dimensions.ai/details/publication/pub.1075969826
27 https://app.dimensions.ai/details/publication/pub.1078834524
28 https://app.dimensions.ai/details/publication/pub.1079447846
29 https://app.dimensions.ai/details/publication/pub.1079833434
30 https://app.dimensions.ai/details/publication/pub.1080018650
31 https://app.dimensions.ai/details/publication/pub.1082424203
32 https://app.dimensions.ai/details/publication/pub.1082466962
33 https://app.dimensions.ai/details/publication/pub.1082472515
34 https://app.dimensions.ai/details/publication/pub.1082482166
35 https://app.dimensions.ai/details/publication/pub.1082561246
36 https://app.dimensions.ai/details/publication/pub.1082562872
37 https://app.dimensions.ai/details/publication/pub.1082563636
38 https://app.dimensions.ai/details/publication/pub.1082570108
39 https://app.dimensions.ai/details/publication/pub.1082570150
40 https://app.dimensions.ai/details/publication/pub.1082650029
41 https://app.dimensions.ai/details/publication/pub.1082790842
42 https://app.dimensions.ai/details/publication/pub.1083347496
43 https://doi.org/10.1016/0008-8749(92)90011-d
44 https://doi.org/10.1016/s0889-8588(18)30598-7
45 https://doi.org/10.1056/nejm198704093161501
46 https://doi.org/10.1073/pnas.87.17.6808
47 https://doi.org/10.1084/jem.159.2.495
48 https://doi.org/10.1084/jem.170.3.827
49 https://doi.org/10.1084/jem.178.2.413
50 https://doi.org/10.1084/jem.178.4.1223
51 https://doi.org/10.1093/intimm/6.1.157
52 https://doi.org/10.1093/jnci/61.6.1499
53 https://doi.org/10.1126/science.7904381
54 https://doi.org/10.1146/annurev.iy.13.040195.001343
55 https://doi.org/10.1200/jco.1990.8.4.638
56 https://doi.org/10.3892/ijo.7.2.205
57 schema:datePublished 1996-05
58 schema:datePublishedReg 1996-05-01
59 schema:description Despite considerable advancement in anticancer therapy, minimal residual disease (MRD) is still a major problem in the clinical management of cancer, including lymphoma. In this report, we have studied the antitumor effects of interleukin-12 (IL-12) against an aggressive liver metastatic murine RAW117-H10 lymphoma. Our results using three different doses of IL-12 (0.175, 0.35 and 0.7 micrograms/mouse) showed that a 0.35 micrograms dose is the most efficacious against lymphoma grown in intact mice. Furthermore, we have evaluated the therapeutic effects of IL-12 against residual lymphoma in a transplantation setting. BALB/c mice were treated with high-dose therapy (HDT) and transplanted with syngeneic bone marrow cells added with a known number of RAW117-H10 lymphoma cells to mimic the clinical situation of MRD. The mice were then treated with IL-12 (0.25 micrograms/mouse/day) alone or IL-12 plus activated cytotoxic effector cells. Our results showed that IL-12 had a significant (P < 0.05) antitumor therapeutic effect against liver metastatic lymphoma grown in intact mice as well as in lymphoma-bearing mice treated with HDT followed by stem cell transplantation as determined by survival period. The therapeutic effect of IL-12 was also demonstrated by a very significant decrease (P < 0.05) in the tumor burden in livers from the IL-12-treated mice. Mice that were treated with IL-12 following HDT and hematopoietic stem cell transplantation had a significant decrease in circulating white blood cells (P < 0.05), a significant increase in spleen weight and cellularity (P < 0.05), and hematopoietic progenitor cells (P < 0.05), a significant increase in the number of splenocytes expressing IL-2 alpha-chain receptor (P < 0.05), and an increase in the frequency of natural killer cells in their spleens. These studies suggest that cytokines such as IL-12 may have the potential to mediate antitumor effects against residual lymphoma without compromising lymphohematopoietic recovery.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree false
63 schema:isPartOf N67dedd2909834d27972acde6ad0912ea
64 Ne21ef45f105043dfba947009eb552701
65 sg:journal.1094856
66 schema:name In vivo therapeutic effects of interleukin-12 against highly metastatic residual lymphoma
67 schema:pagination 219-229
68 schema:productId N4438204f7eac4227af2cabc0a46d803b
69 N5db1c43dc2264395a47b45906ccd51db
70 Na397289ef2cd422c88843e42ce67eaa6
71 Nf6839fc70237409aa76af0b94b1c0559
72 Nfe9ef6b3fcd443d4a71dbe25e96c3549
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013328260
74 https://doi.org/10.1007/bf00053895
75 schema:sdDatePublished 2019-04-11T01:53
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher Ndfb1c69b6d47491b8b22ab6005b6c062
78 schema:url http://link.springer.com/10.1007/BF00053895
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N04966b3801b44c80abae3a67f683ee70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Spleen
84 rdf:type schema:DefinedTerm
85 N0a7ea7deac48449bbcc32d65c60fb1e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Animals
87 rdf:type schema:DefinedTerm
88 N0f7043638c544328a2ff584eceb7699a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Bone Marrow Transplantation
90 rdf:type schema:DefinedTerm
91 N1265cda33ae542029b9ad8cac099d153 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Organ Size
93 rdf:type schema:DefinedTerm
94 N3424a213217f4f6ba2f20fda2619df8d rdf:first sg:person.01271073640.53
95 rdf:rest N51931a7def38483db384d2ea9baeb018
96 N3899ca18335d4ce694165598b2971660 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Neoplasm Transplantation
98 rdf:type schema:DefinedTerm
99 N3f435fce02284c90979142c60db6293a schema:affiliation https://www.grid.ac/institutes/grid.266813.8
100 schema:familyName Kessingert
101 schema:givenName Anne
102 rdf:type schema:Person
103 N43fe9b14137b4d558ae16e9d25e58575 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Tumor Cells, Cultured
105 rdf:type schema:DefinedTerm
106 N4438204f7eac4227af2cabc0a46d803b schema:name dimensions_id
107 schema:value pub.1013328260
108 rdf:type schema:PropertyValue
109 N4e6b9427fa864933bae3473d5150bc2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Lymphoma, B-Cell
111 rdf:type schema:DefinedTerm
112 N51545c34e6274788939c0bbeadde5519 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Stem Cells
114 rdf:type schema:DefinedTerm
115 N51931a7def38483db384d2ea9baeb018 rdf:first sg:person.01135506727.76
116 rdf:rest N6cac312b498f433a89de4e2cd1f9b9ad
117 N5c87d811c81747c98170907df4625f7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Lymphoma
119 rdf:type schema:DefinedTerm
120 N5db1c43dc2264395a47b45906ccd51db schema:name readcube_id
121 schema:value 3f7e1c8d9bb89a342683763afc3e2cad0db18b2525b0c07d5e333a9dc258b924
122 rdf:type schema:PropertyValue
123 N67dedd2909834d27972acde6ad0912ea schema:issueNumber 3
124 rdf:type schema:PublicationIssue
125 N6cac312b498f433a89de4e2cd1f9b9ad rdf:first N3f435fce02284c90979142c60db6293a
126 rdf:rest Ndb0f729171c74571bae96ec3b29c4524
127 N822f1bebb8ad48d2ae341eee8030ffc2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Interleukin-12
129 rdf:type schema:DefinedTerm
130 Na005656e2ad84aabb608b1d38657b560 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Female
132 rdf:type schema:DefinedTerm
133 Na397289ef2cd422c88843e42ce67eaa6 schema:name doi
134 schema:value 10.1007/bf00053895
135 rdf:type schema:PropertyValue
136 Nb0b0bbf746e84059ada2b6f06d3d03c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Interleukin-2
138 rdf:type schema:DefinedTerm
139 Nb557c5e3f74142659ae6cd2571f05f66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Mice, Inbred BALB C
141 rdf:type schema:DefinedTerm
142 Nc07841fb2f044404a8bab55a085c4b25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Antineoplastic Agents
144 rdf:type schema:DefinedTerm
145 Nc57b53086af1485a8701d2186e24d60b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Hematopoietic Stem Cell Transplantation
147 rdf:type schema:DefinedTerm
148 Ndb0f729171c74571bae96ec3b29c4524 rdf:first sg:person.07355130657.98
149 rdf:rest rdf:nil
150 Ndbfa60861f734c6586f77a6ad0d8dd72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Hematopoiesis
152 rdf:type schema:DefinedTerm
153 Ndc1e004edfeb41a79992c07f0bccc147 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Liver Neoplasms, Experimental
155 rdf:type schema:DefinedTerm
156 Ndfb1c69b6d47491b8b22ab6005b6c062 schema:name Springer Nature - SN SciGraph project
157 rdf:type schema:Organization
158 Ne21ef45f105043dfba947009eb552701 schema:volumeNumber 14
159 rdf:type schema:PublicationVolume
160 Ne5a13f38153f49fb847e7bd64601b305 rdf:first sg:person.0613050014.37
161 rdf:rest N3424a213217f4f6ba2f20fda2619df8d
162 Ne6a5589b94694b0d980f7a221d05c0d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Neoplasm, Residual
164 rdf:type schema:DefinedTerm
165 Ne7f44d0828d5422aae71cedfad17d041 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Time Factors
167 rdf:type schema:DefinedTerm
168 Nf4857c8526914844b195c7e2ba71237c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Immunophenotyping
170 rdf:type schema:DefinedTerm
171 Nf6839fc70237409aa76af0b94b1c0559 schema:name pubmed_id
172 schema:value 8674276
173 rdf:type schema:PropertyValue
174 Nfcfda802e8f941caa9f6282fe0055b09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Mice
176 rdf:type schema:DefinedTerm
177 Nfe9ef6b3fcd443d4a71dbe25e96c3549 schema:name nlm_unique_id
178 schema:value 8409970
179 rdf:type schema:PropertyValue
180 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
181 schema:name Medical and Health Sciences
182 rdf:type schema:DefinedTerm
183 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
184 schema:name Immunology
185 rdf:type schema:DefinedTerm
186 sg:journal.1094856 schema:issn 0262-0898
187 1573-7276
188 schema:name Clinical & Experimental Metastasis
189 rdf:type schema:Periodical
190 sg:person.01135506727.76 schema:affiliation https://www.grid.ac/institutes/grid.418158.1
191 schema:familyName Brunda
192 schema:givenName Michael J.
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135506727.76
194 rdf:type schema:Person
195 sg:person.01271073640.53 schema:affiliation https://www.grid.ac/institutes/grid.266813.8
196 schema:familyName Stinson
197 schema:givenName Warren W.
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271073640.53
199 rdf:type schema:Person
200 sg:person.0613050014.37 schema:affiliation https://www.grid.ac/institutes/grid.266813.8
201 schema:familyName Verbik
202 schema:givenName David J.
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613050014.37
204 rdf:type schema:Person
205 sg:person.07355130657.98 schema:affiliation https://www.grid.ac/institutes/grid.266813.8
206 schema:familyName Joshi
207 schema:givenName Shantaram S.
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07355130657.98
209 rdf:type schema:Person
210 sg:pub.10.1007/bf00915477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013786924
211 https://doi.org/10.1007/bf00915477
212 rdf:type schema:CreativeWork
213 https://app.dimensions.ai/details/publication/pub.1075969826 schema:CreativeWork
214 https://app.dimensions.ai/details/publication/pub.1078834524 schema:CreativeWork
215 https://app.dimensions.ai/details/publication/pub.1079447846 schema:CreativeWork
216 https://app.dimensions.ai/details/publication/pub.1079833434 schema:CreativeWork
217 https://app.dimensions.ai/details/publication/pub.1080018650 schema:CreativeWork
218 https://app.dimensions.ai/details/publication/pub.1082424203 schema:CreativeWork
219 https://app.dimensions.ai/details/publication/pub.1082466962 schema:CreativeWork
220 https://app.dimensions.ai/details/publication/pub.1082472515 schema:CreativeWork
221 https://app.dimensions.ai/details/publication/pub.1082482166 schema:CreativeWork
222 https://app.dimensions.ai/details/publication/pub.1082561246 schema:CreativeWork
223 https://app.dimensions.ai/details/publication/pub.1082562872 schema:CreativeWork
224 https://app.dimensions.ai/details/publication/pub.1082563636 schema:CreativeWork
225 https://app.dimensions.ai/details/publication/pub.1082570108 schema:CreativeWork
226 https://app.dimensions.ai/details/publication/pub.1082570150 schema:CreativeWork
227 https://app.dimensions.ai/details/publication/pub.1082650029 schema:CreativeWork
228 https://app.dimensions.ai/details/publication/pub.1082790842 schema:CreativeWork
229 https://app.dimensions.ai/details/publication/pub.1083347496 schema:CreativeWork
230 https://doi.org/10.1016/0008-8749(92)90011-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1013827432
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/s0889-8588(18)30598-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079527656
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1056/nejm198704093161501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029831566
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1073/pnas.87.17.6808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014530928
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1084/jem.159.2.495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013352472
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1084/jem.170.3.827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035451194
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1084/jem.178.2.413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050103182
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1084/jem.178.4.1223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019000723
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1093/intimm/6.1.157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059712008
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1093/jnci/61.6.1499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079407578
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1126/science.7904381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062650591
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1146/annurev.iy.13.040195.001343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015038538
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1200/jco.1990.8.4.638 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078644595
255 rdf:type schema:CreativeWork
256 https://doi.org/10.3892/ijo.7.2.205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071517482
257 rdf:type schema:CreativeWork
258 https://www.grid.ac/institutes/grid.266813.8 schema:alternateName University of Nebraska Medical Center
259 schema:name Departments of Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA
260 Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA
261 rdf:type schema:Organization
262 https://www.grid.ac/institutes/grid.418158.1 schema:alternateName Roche (United States)
263 schema:name Department of OncologyDepartment of OncologyDepartment of Oncology, Hoffmann-La Roche Inc., NJ, USA
264 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...