Rationale and methods for the use of nude mice to study the biology and therapy of human cancer metastasis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-03

AUTHORS

Isaiah J. Fidler

ABSTRACT

Human neoplasms are biologically heterogeneous. The extensive cellular diversity found in malignant neoplasms is generated by the rapid emergence of clonal subpopulations of tumor cells with different properties that include invasion, metastasis and responsiveness to treatment. Studies in rodent systems have indicated that cancer metastases can be clonal in their origin and that different metastases can originate from different progenitor cells from the primary tumor. This metastatic heterogeneity of tumor cells has many ramifications for studies of tumor biology, in general, and studies of therapy, in particular. The heterogeneous nature of metastatic human neoplasms can now be studied under defined conditions in healthy athymic nude mice. The neoplasms must be free of mouse pathogens and the mice must be kept in specific-pathogen-free conditions. Careful consideration must be given to the intimate tumor-host relationship for each tumor system studied, because the metastatic potential of human neoplasms can vary with the site of implantation into nude mice. Several methods for studying the biology of human neoplasms in the nude mouse are described as well as techniques to assure the success of these studies. The data show that the healthy young nude mouse can be a useful in vivo model for ascertaining the metastatic potential of human neoplasms, for selecting and maintaining cell variants of high metastatic potential from heterogeneous human tumors, and for studying therapeutic agents directed against metastatic cells proliferating in visceral organs. More... »

PAGES

29-49

References to SciGraph publications

  • 1982-03. ‘Seed and soil’ revisited: mechanisms of site-specific metastasis in CANCER AND METASTASIS REVIEWS
  • 1981-02. Distinct lung-colonizing and lung-metastasizing cell populations in B16 mouse melanoma in NATURE
  • 1973-04. Selection of Successive Tumour Lines for Metastasis in NATURE
  • 1980-03. Tumor cell antigenicity, host immunity, and cancer metastasis in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 1975-07. The influence of site of metastasis on tumour growth and response to chemotherapy in BRITISH JOURNAL OF CANCER
  • 1978-08. Gradients in tumour growth in NATURE
  • 1984-12. Clinical perspective of human colorectal cancer metastasis in CANCER AND METASTASIS REVIEWS
  • 1983-03. The selective nature of metastasis in CANCER AND METASTASIS REVIEWS
  • 1982-06. Cancer metastasis is selective or random depending on the parent tumour population in NATURE
  • 1980-04. Role of NK cells in tumour growth and metastasis in beige mice in NATURE
  • 1982-03. NK cell-target interactions: approaches towards definition of recognition structures in CANCER AND METASTASIS REVIEWS
  • 1982-03. Role of natural killer cells in control of cancer metastasis in CANCER AND METASTASIS REVIEWS
  • 1982-06. Experimental systems for analysis of the malignant phenotype in CANCER AND METASTASIS REVIEWS
  • 1984-12. Considerations in the use of nude mice for cancer research in CANCER AND METASTASIS REVIEWS
  • 1982-09. Investigations of the mechanisms of metastatic spread of naturally occurring neoplasms in CANCER AND METASTASIS REVIEWS
  • 1980-01. The pathogenesis of cancer metastasis in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00049529

    DOI

    http://dx.doi.org/10.1007/bf00049529

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1051172464

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2942306


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinoma, Renal Cell", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Colonic Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Kidney Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Liver Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lung Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Melanoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Nude", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Metastasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Transplantation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms, Experimental", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Specific Pathogen-Free Organisms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transplantation, Heterologous", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Department of Cell Biology, University of Texas, M. D. Anderson Hospital and Tumor Institute, Houston, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fidler", 
            "givenName": "Isaiah J.", 
            "id": "sg:person.01070261656.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070261656.78"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1002/ijc.2910110105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001458963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.2910230320", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001570462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/297593a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004806110", 
              "https://doi.org/10.1038/297593a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1699-0463.1976.tb00104.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006252547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1699-0463.1976.tb00104.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006252547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00046904", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006421849", 
              "https://doi.org/10.1007/bf00046904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00046904", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006421849", 
              "https://doi.org/10.1007/bf00046904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.2910020503", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007887821"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0142(197605)37:5<2158::aid-cncr2820370503>3.0.co;2-f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008742702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(00)49915-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009998242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(00)49915-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009998242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000280401", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010071075"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/274697a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010501223", 
              "https://doi.org/10.1038/274697a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00049480", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011536138", 
              "https://doi.org/10.1007/bf00049480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00049480", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011536138", 
              "https://doi.org/10.1007/bf00049480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.79.7.2389", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012439415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.1.5901.218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012824106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00049481", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014020350", 
              "https://doi.org/10.1007/bf00049481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00049481", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014020350", 
              "https://doi.org/10.1007/bf00049481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/283139a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014668798", 
              "https://doi.org/10.1038/283139a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000163001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015868226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000402511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019984291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00048224", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027491680", 
              "https://doi.org/10.1007/bf00048224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00048224", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027491680", 
              "https://doi.org/10.1007/bf00048224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1699-0463.1969.tb04520.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029316942"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1699-0463.1969.tb04520.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029316942"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/284622a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029415130", 
              "https://doi.org/10.1038/284622a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00051457", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031528577", 
              "https://doi.org/10.1007/bf00051457"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00051457", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031528577", 
              "https://doi.org/10.1007/bf00051457"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.2910260521", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032966759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0304-419x(82)90020-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033858849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0304-419x(82)90020-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033858849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00049477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036251065", 
              "https://doi.org/10.1007/bf00049477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00049477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036251065", 
              "https://doi.org/10.1007/bf00049477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00205466", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041043496", 
              "https://doi.org/10.1007/bf00205466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00205466", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041043496", 
              "https://doi.org/10.1007/bf00205466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/newbio242148a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043302187", 
              "https://doi.org/10.1038/newbio242148a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/newbio242148a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043302187", 
              "https://doi.org/10.1038/newbio242148a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/newbio242148a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043302187", 
              "https://doi.org/10.1038/newbio242148a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1975.135", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045178610", 
              "https://doi.org/10.1038/bjc.1975.135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1975.135", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045178610", 
              "https://doi.org/10.1038/bjc.1975.135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.2910240605", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046354239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.1.6013.801", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047734525"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00051459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048999989", 
              "https://doi.org/10.1007/bf00051459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00051459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048999989", 
              "https://doi.org/10.1007/bf00051459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0065-230x(08)60648-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051538099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.2910300319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051914105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00046828", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052988463", 
              "https://doi.org/10.1007/bf00046828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00046828", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052988463", 
              "https://doi.org/10.1007/bf00046828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/289798a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053081105", 
              "https://doi.org/10.1038/289798a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.6953592", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062641948"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7053564", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062643380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7053568", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062643384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7112116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062644179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7209521", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062644932"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.887927", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062658092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/55.6.1461", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075070858"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-5347(17)59208-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075251501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077357078", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/56.6.1251", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077681482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078423190", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079204684", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/62.5.1151", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079429516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/77.6.1303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079766610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079921433", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1986.4.2.244", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1080047767"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080049016", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080067582", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080100494", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080231231", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080356731", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/50.4.1051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1080539138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/45.4.773", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1081134910"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081426001", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/60.4.925", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1081684431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081687745", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081707773", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081767915", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081802316", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/72.4.913", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1081839969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081899743", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-5347(17)50244-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1081907443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-5347(17)50245-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1081907444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081908020", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081934704", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081934709", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081934726", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/69.4.975", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1081937793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081951672", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081991567", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082009674", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/65.4.801", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082047563"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/67.3.663", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082056560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/69.1.137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082063474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082158305", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-5347(17)53357-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082196319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082209464", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082325604", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082353994", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082356833", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082359994", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082796423", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/56.2.325", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083199723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083321391", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/66.6.1183", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083578869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1108071905", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1986-03", 
        "datePublishedReg": "1986-03-01", 
        "description": "Human neoplasms are biologically heterogeneous. The extensive cellular diversity found in malignant neoplasms is generated by the rapid emergence of clonal subpopulations of tumor cells with different properties that include invasion, metastasis and responsiveness to treatment. Studies in rodent systems have indicated that cancer metastases can be clonal in their origin and that different metastases can originate from different progenitor cells from the primary tumor. This metastatic heterogeneity of tumor cells has many ramifications for studies of tumor biology, in general, and studies of therapy, in particular. The heterogeneous nature of metastatic human neoplasms can now be studied under defined conditions in healthy athymic nude mice. The neoplasms must be free of mouse pathogens and the mice must be kept in specific-pathogen-free conditions. Careful consideration must be given to the intimate tumor-host relationship for each tumor system studied, because the metastatic potential of human neoplasms can vary with the site of implantation into nude mice. Several methods for studying the biology of human neoplasms in the nude mouse are described as well as techniques to assure the success of these studies. The data show that the healthy young nude mouse can be a useful in vivo model for ascertaining the metastatic potential of human neoplasms, for selecting and maintaining cell variants of high metastatic potential from heterogeneous human tumors, and for studying therapeutic agents directed against metastatic cells proliferating in visceral organs.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/bf00049529", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1096239", 
            "issn": [
              "0167-7659", 
              "1573-7233"
            ], 
            "name": "Cancer and Metastasis Reviews", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "5"
          }
        ], 
        "name": "Rationale and methods for the use of nude mice to study the biology and therapy of human cancer metastasis", 
        "pagination": "29-49", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "f3c42fd53843c295dfcfa1d97b45d6d29f9f188bc3749ce44851fb726eb576d7"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "2942306"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8605731"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/bf00049529"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1051172464"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/bf00049529", 
          "https://app.dimensions.ai/details/publication/pub.1051172464"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:50", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130797_00000004.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007/BF00049529"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00049529'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00049529'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00049529'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00049529'


     

    This table displays all metadata directly associated to this object as RDF triples.

    387 TRIPLES      21 PREDICATES      135 URIs      37 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/bf00049529 schema:about N13526e559389420e9c6dec32c6e634a0
    2 N502672e6966a41b09350590f68d610cc
    3 N6b8d0a463d1e464b8b36f361e16c382d
    4 N71f74b723a6d4346839e6299c929eef6
    5 N7b03ac2dac6d499d9f2ebedd53bdd4ce
    6 N7b1761ee76504ba789b1bb87d2e62c70
    7 N88295b3bf1204683988794329d752a0d
    8 N8c567e2b36c94f3b8ad789745a20723a
    9 Nab3b5d37fa1848a8973fd204bf6e4dd3
    10 Nab441d3eea23415590887b137fa48e64
    11 Nb4233db8e2f443818f39ba7e69195230
    12 Nccdfc227dda2415dbf5625203cedae6a
    13 Ne8c824f4b0c4460ebac5ec78f81542eb
    14 Neb1d2fb30771489b931672d5d5e84f2d
    15 Nf72cf1637b904e5eab35c68993f42587
    16 Nf91dd272b55b453eba3ad50525748383
    17 anzsrc-for:11
    18 anzsrc-for:1112
    19 schema:author N13e8a464e5ef48bf99959c8c88a605e8
    20 schema:citation sg:pub.10.1007/bf00046828
    21 sg:pub.10.1007/bf00046904
    22 sg:pub.10.1007/bf00048224
    23 sg:pub.10.1007/bf00049477
    24 sg:pub.10.1007/bf00049480
    25 sg:pub.10.1007/bf00049481
    26 sg:pub.10.1007/bf00051457
    27 sg:pub.10.1007/bf00051459
    28 sg:pub.10.1007/bf00205466
    29 sg:pub.10.1038/274697a0
    30 sg:pub.10.1038/283139a0
    31 sg:pub.10.1038/284622a0
    32 sg:pub.10.1038/289798a0
    33 sg:pub.10.1038/297593a0
    34 sg:pub.10.1038/bjc.1975.135
    35 sg:pub.10.1038/newbio242148a0
    36 https://app.dimensions.ai/details/publication/pub.1077357078
    37 https://app.dimensions.ai/details/publication/pub.1078423190
    38 https://app.dimensions.ai/details/publication/pub.1079204684
    39 https://app.dimensions.ai/details/publication/pub.1079921433
    40 https://app.dimensions.ai/details/publication/pub.1080049016
    41 https://app.dimensions.ai/details/publication/pub.1080067582
    42 https://app.dimensions.ai/details/publication/pub.1080100494
    43 https://app.dimensions.ai/details/publication/pub.1080231231
    44 https://app.dimensions.ai/details/publication/pub.1080356731
    45 https://app.dimensions.ai/details/publication/pub.1081426001
    46 https://app.dimensions.ai/details/publication/pub.1081687745
    47 https://app.dimensions.ai/details/publication/pub.1081707773
    48 https://app.dimensions.ai/details/publication/pub.1081767915
    49 https://app.dimensions.ai/details/publication/pub.1081802316
    50 https://app.dimensions.ai/details/publication/pub.1081899743
    51 https://app.dimensions.ai/details/publication/pub.1081908020
    52 https://app.dimensions.ai/details/publication/pub.1081934704
    53 https://app.dimensions.ai/details/publication/pub.1081934709
    54 https://app.dimensions.ai/details/publication/pub.1081934726
    55 https://app.dimensions.ai/details/publication/pub.1081951672
    56 https://app.dimensions.ai/details/publication/pub.1081991567
    57 https://app.dimensions.ai/details/publication/pub.1082009674
    58 https://app.dimensions.ai/details/publication/pub.1082158305
    59 https://app.dimensions.ai/details/publication/pub.1082209464
    60 https://app.dimensions.ai/details/publication/pub.1082325604
    61 https://app.dimensions.ai/details/publication/pub.1082353994
    62 https://app.dimensions.ai/details/publication/pub.1082356833
    63 https://app.dimensions.ai/details/publication/pub.1082359994
    64 https://app.dimensions.ai/details/publication/pub.1082796423
    65 https://app.dimensions.ai/details/publication/pub.1083321391
    66 https://app.dimensions.ai/details/publication/pub.1108071905
    67 https://doi.org/10.1002/1097-0142(197605)37:5<2158::aid-cncr2820370503>3.0.co;2-f
    68 https://doi.org/10.1002/ijc.2910020503
    69 https://doi.org/10.1002/ijc.2910110105
    70 https://doi.org/10.1002/ijc.2910230320
    71 https://doi.org/10.1002/ijc.2910240605
    72 https://doi.org/10.1002/ijc.2910260521
    73 https://doi.org/10.1002/ijc.2910300319
    74 https://doi.org/10.1016/0304-419x(82)90020-8
    75 https://doi.org/10.1016/s0022-5347(17)50244-x
    76 https://doi.org/10.1016/s0022-5347(17)50245-1
    77 https://doi.org/10.1016/s0022-5347(17)53357-1
    78 https://doi.org/10.1016/s0022-5347(17)59208-3
    79 https://doi.org/10.1016/s0065-230x(08)60648-x
    80 https://doi.org/10.1016/s0140-6736(00)49915-0
    81 https://doi.org/10.1073/pnas.79.7.2389
    82 https://doi.org/10.1093/jnci/45.4.773
    83 https://doi.org/10.1093/jnci/50.4.1051
    84 https://doi.org/10.1093/jnci/55.6.1461
    85 https://doi.org/10.1093/jnci/56.2.325
    86 https://doi.org/10.1093/jnci/56.6.1251
    87 https://doi.org/10.1093/jnci/60.4.925
    88 https://doi.org/10.1093/jnci/62.5.1151
    89 https://doi.org/10.1093/jnci/65.4.801
    90 https://doi.org/10.1093/jnci/66.6.1183
    91 https://doi.org/10.1093/jnci/67.3.663
    92 https://doi.org/10.1093/jnci/69.1.137
    93 https://doi.org/10.1093/jnci/69.4.975
    94 https://doi.org/10.1093/jnci/72.4.913
    95 https://doi.org/10.1093/jnci/77.6.1303
    96 https://doi.org/10.1111/j.1699-0463.1969.tb04520.x
    97 https://doi.org/10.1111/j.1699-0463.1976.tb00104.x
    98 https://doi.org/10.1126/science.6953592
    99 https://doi.org/10.1126/science.7053564
    100 https://doi.org/10.1126/science.7053568
    101 https://doi.org/10.1126/science.7112116
    102 https://doi.org/10.1126/science.7209521
    103 https://doi.org/10.1126/science.887927
    104 https://doi.org/10.1136/bmj.1.5901.218
    105 https://doi.org/10.1136/bmj.1.6013.801
    106 https://doi.org/10.1159/000163001
    107 https://doi.org/10.1159/000280401
    108 https://doi.org/10.1159/000402511
    109 https://doi.org/10.1200/jco.1986.4.2.244
    110 schema:datePublished 1986-03
    111 schema:datePublishedReg 1986-03-01
    112 schema:description Human neoplasms are biologically heterogeneous. The extensive cellular diversity found in malignant neoplasms is generated by the rapid emergence of clonal subpopulations of tumor cells with different properties that include invasion, metastasis and responsiveness to treatment. Studies in rodent systems have indicated that cancer metastases can be clonal in their origin and that different metastases can originate from different progenitor cells from the primary tumor. This metastatic heterogeneity of tumor cells has many ramifications for studies of tumor biology, in general, and studies of therapy, in particular. The heterogeneous nature of metastatic human neoplasms can now be studied under defined conditions in healthy athymic nude mice. The neoplasms must be free of mouse pathogens and the mice must be kept in specific-pathogen-free conditions. Careful consideration must be given to the intimate tumor-host relationship for each tumor system studied, because the metastatic potential of human neoplasms can vary with the site of implantation into nude mice. Several methods for studying the biology of human neoplasms in the nude mouse are described as well as techniques to assure the success of these studies. The data show that the healthy young nude mouse can be a useful in vivo model for ascertaining the metastatic potential of human neoplasms, for selecting and maintaining cell variants of high metastatic potential from heterogeneous human tumors, and for studying therapeutic agents directed against metastatic cells proliferating in visceral organs.
    113 schema:genre research_article
    114 schema:inLanguage en
    115 schema:isAccessibleForFree false
    116 schema:isPartOf N919d93497c1346f2880da490df9156cc
    117 Ne246bcbe5c1f41849170b0be8a0ee344
    118 sg:journal.1096239
    119 schema:name Rationale and methods for the use of nude mice to study the biology and therapy of human cancer metastasis
    120 schema:pagination 29-49
    121 schema:productId N1c9b39cf8a7f467b860a5b303e7296d6
    122 N22b064478f8544678eeb5e48c09863d0
    123 N340b09e0051946378a2c860ff75ca749
    124 N8a75f1ddee794043aa0d72713d22a624
    125 Nd04393ba7bd94544af8005daed2bf076
    126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051172464
    127 https://doi.org/10.1007/bf00049529
    128 schema:sdDatePublished 2019-04-11T13:50
    129 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    130 schema:sdPublisher N21b03324216d47e9a0fd871c3d3b206b
    131 schema:url http://link.springer.com/10.1007/BF00049529
    132 sgo:license sg:explorer/license/
    133 sgo:sdDataset articles
    134 rdf:type schema:ScholarlyArticle
    135 N13526e559389420e9c6dec32c6e634a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Cell Line
    137 rdf:type schema:DefinedTerm
    138 N13e8a464e5ef48bf99959c8c88a605e8 rdf:first sg:person.01070261656.78
    139 rdf:rest rdf:nil
    140 N1c9b39cf8a7f467b860a5b303e7296d6 schema:name dimensions_id
    141 schema:value pub.1051172464
    142 rdf:type schema:PropertyValue
    143 N21b03324216d47e9a0fd871c3d3b206b schema:name Springer Nature - SN SciGraph project
    144 rdf:type schema:Organization
    145 N22b064478f8544678eeb5e48c09863d0 schema:name pubmed_id
    146 schema:value 2942306
    147 rdf:type schema:PropertyValue
    148 N340b09e0051946378a2c860ff75ca749 schema:name nlm_unique_id
    149 schema:value 8605731
    150 rdf:type schema:PropertyValue
    151 N502672e6966a41b09350590f68d610cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Animals
    153 rdf:type schema:DefinedTerm
    154 N6b8d0a463d1e464b8b36f361e16c382d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Liver Neoplasms
    156 rdf:type schema:DefinedTerm
    157 N71f74b723a6d4346839e6299c929eef6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Transplantation, Heterologous
    159 rdf:type schema:DefinedTerm
    160 N7b03ac2dac6d499d9f2ebedd53bdd4ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Specific Pathogen-Free Organisms
    162 rdf:type schema:DefinedTerm
    163 N7b1761ee76504ba789b1bb87d2e62c70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Carcinoma, Renal Cell
    165 rdf:type schema:DefinedTerm
    166 N88295b3bf1204683988794329d752a0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Melanoma
    168 rdf:type schema:DefinedTerm
    169 N8a75f1ddee794043aa0d72713d22a624 schema:name readcube_id
    170 schema:value f3c42fd53843c295dfcfa1d97b45d6d29f9f188bc3749ce44851fb726eb576d7
    171 rdf:type schema:PropertyValue
    172 N8c567e2b36c94f3b8ad789745a20723a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Humans
    174 rdf:type schema:DefinedTerm
    175 N919d93497c1346f2880da490df9156cc schema:volumeNumber 5
    176 rdf:type schema:PublicationVolume
    177 Nab3b5d37fa1848a8973fd204bf6e4dd3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Neoplasms, Experimental
    179 rdf:type schema:DefinedTerm
    180 Nab441d3eea23415590887b137fa48e64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Mice, Nude
    182 rdf:type schema:DefinedTerm
    183 Nb4233db8e2f443818f39ba7e69195230 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Kidney Neoplasms
    185 rdf:type schema:DefinedTerm
    186 Nccdfc227dda2415dbf5625203cedae6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Neoplasm Metastasis
    188 rdf:type schema:DefinedTerm
    189 Nd04393ba7bd94544af8005daed2bf076 schema:name doi
    190 schema:value 10.1007/bf00049529
    191 rdf:type schema:PropertyValue
    192 Ne246bcbe5c1f41849170b0be8a0ee344 schema:issueNumber 1
    193 rdf:type schema:PublicationIssue
    194 Ne8c824f4b0c4460ebac5ec78f81542eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Colonic Neoplasms
    196 rdf:type schema:DefinedTerm
    197 Neb1d2fb30771489b931672d5d5e84f2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Lung Neoplasms
    199 rdf:type schema:DefinedTerm
    200 Nf72cf1637b904e5eab35c68993f42587 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    201 schema:name Mice
    202 rdf:type schema:DefinedTerm
    203 Nf91dd272b55b453eba3ad50525748383 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    204 schema:name Neoplasm Transplantation
    205 rdf:type schema:DefinedTerm
    206 Nfb26f458e5e24fcc90fda59a7f71441d schema:name Department of Cell Biology, University of Texas, M. D. Anderson Hospital and Tumor Institute, Houston, USA
    207 rdf:type schema:Organization
    208 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    209 schema:name Medical and Health Sciences
    210 rdf:type schema:DefinedTerm
    211 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    212 schema:name Oncology and Carcinogenesis
    213 rdf:type schema:DefinedTerm
    214 sg:journal.1096239 schema:issn 0167-7659
    215 1573-7233
    216 schema:name Cancer and Metastasis Reviews
    217 rdf:type schema:Periodical
    218 sg:person.01070261656.78 schema:affiliation Nfb26f458e5e24fcc90fda59a7f71441d
    219 schema:familyName Fidler
    220 schema:givenName Isaiah J.
    221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070261656.78
    222 rdf:type schema:Person
    223 sg:pub.10.1007/bf00046828 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052988463
    224 https://doi.org/10.1007/bf00046828
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1007/bf00046904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006421849
    227 https://doi.org/10.1007/bf00046904
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1007/bf00048224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027491680
    230 https://doi.org/10.1007/bf00048224
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1007/bf00049477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036251065
    233 https://doi.org/10.1007/bf00049477
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1007/bf00049480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011536138
    236 https://doi.org/10.1007/bf00049480
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1007/bf00049481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014020350
    239 https://doi.org/10.1007/bf00049481
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1007/bf00051457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031528577
    242 https://doi.org/10.1007/bf00051457
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1007/bf00051459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048999989
    245 https://doi.org/10.1007/bf00051459
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1007/bf00205466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041043496
    248 https://doi.org/10.1007/bf00205466
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/274697a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010501223
    251 https://doi.org/10.1038/274697a0
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/283139a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014668798
    254 https://doi.org/10.1038/283139a0
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/284622a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029415130
    257 https://doi.org/10.1038/284622a0
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/289798a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053081105
    260 https://doi.org/10.1038/289798a0
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/297593a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004806110
    263 https://doi.org/10.1038/297593a0
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/bjc.1975.135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045178610
    266 https://doi.org/10.1038/bjc.1975.135
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/newbio242148a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043302187
    269 https://doi.org/10.1038/newbio242148a0
    270 rdf:type schema:CreativeWork
    271 https://app.dimensions.ai/details/publication/pub.1077357078 schema:CreativeWork
    272 https://app.dimensions.ai/details/publication/pub.1078423190 schema:CreativeWork
    273 https://app.dimensions.ai/details/publication/pub.1079204684 schema:CreativeWork
    274 https://app.dimensions.ai/details/publication/pub.1079921433 schema:CreativeWork
    275 https://app.dimensions.ai/details/publication/pub.1080049016 schema:CreativeWork
    276 https://app.dimensions.ai/details/publication/pub.1080067582 schema:CreativeWork
    277 https://app.dimensions.ai/details/publication/pub.1080100494 schema:CreativeWork
    278 https://app.dimensions.ai/details/publication/pub.1080231231 schema:CreativeWork
    279 https://app.dimensions.ai/details/publication/pub.1080356731 schema:CreativeWork
    280 https://app.dimensions.ai/details/publication/pub.1081426001 schema:CreativeWork
    281 https://app.dimensions.ai/details/publication/pub.1081687745 schema:CreativeWork
    282 https://app.dimensions.ai/details/publication/pub.1081707773 schema:CreativeWork
    283 https://app.dimensions.ai/details/publication/pub.1081767915 schema:CreativeWork
    284 https://app.dimensions.ai/details/publication/pub.1081802316 schema:CreativeWork
    285 https://app.dimensions.ai/details/publication/pub.1081899743 schema:CreativeWork
    286 https://app.dimensions.ai/details/publication/pub.1081908020 schema:CreativeWork
    287 https://app.dimensions.ai/details/publication/pub.1081934704 schema:CreativeWork
    288 https://app.dimensions.ai/details/publication/pub.1081934709 schema:CreativeWork
    289 https://app.dimensions.ai/details/publication/pub.1081934726 schema:CreativeWork
    290 https://app.dimensions.ai/details/publication/pub.1081951672 schema:CreativeWork
    291 https://app.dimensions.ai/details/publication/pub.1081991567 schema:CreativeWork
    292 https://app.dimensions.ai/details/publication/pub.1082009674 schema:CreativeWork
    293 https://app.dimensions.ai/details/publication/pub.1082158305 schema:CreativeWork
    294 https://app.dimensions.ai/details/publication/pub.1082209464 schema:CreativeWork
    295 https://app.dimensions.ai/details/publication/pub.1082325604 schema:CreativeWork
    296 https://app.dimensions.ai/details/publication/pub.1082353994 schema:CreativeWork
    297 https://app.dimensions.ai/details/publication/pub.1082356833 schema:CreativeWork
    298 https://app.dimensions.ai/details/publication/pub.1082359994 schema:CreativeWork
    299 https://app.dimensions.ai/details/publication/pub.1082796423 schema:CreativeWork
    300 https://app.dimensions.ai/details/publication/pub.1083321391 schema:CreativeWork
    301 https://app.dimensions.ai/details/publication/pub.1108071905 schema:CreativeWork
    302 https://doi.org/10.1002/1097-0142(197605)37:5<2158::aid-cncr2820370503>3.0.co;2-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1008742702
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1002/ijc.2910020503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007887821
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1002/ijc.2910110105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001458963
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1002/ijc.2910230320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001570462
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1002/ijc.2910240605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046354239
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1002/ijc.2910260521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032966759
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1002/ijc.2910300319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051914105
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1016/0304-419x(82)90020-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033858849
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1016/s0022-5347(17)50244-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1081907443
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1016/s0022-5347(17)50245-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081907444
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1016/s0022-5347(17)53357-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082196319
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1016/s0022-5347(17)59208-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075251501
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1016/s0065-230x(08)60648-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051538099
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1016/s0140-6736(00)49915-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009998242
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1073/pnas.79.7.2389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012439415
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1093/jnci/45.4.773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081134910
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1093/jnci/50.4.1051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080539138
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1093/jnci/55.6.1461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075070858
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1093/jnci/56.2.325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083199723
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1093/jnci/56.6.1251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077681482
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1093/jnci/60.4.925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081684431
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1093/jnci/62.5.1151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079429516
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1093/jnci/65.4.801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082047563
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1093/jnci/66.6.1183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083578869
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1093/jnci/67.3.663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082056560
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1093/jnci/69.1.137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082063474
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1093/jnci/69.4.975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081937793
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1093/jnci/72.4.913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081839969
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1093/jnci/77.6.1303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079766610
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1111/j.1699-0463.1969.tb04520.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029316942
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1111/j.1699-0463.1976.tb00104.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006252547
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1126/science.6953592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062641948
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1126/science.7053564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062643380
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1126/science.7053568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062643384
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1126/science.7112116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062644179
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1126/science.7209521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062644932
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1126/science.887927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062658092
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1136/bmj.1.5901.218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012824106
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1136/bmj.1.6013.801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047734525
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1159/000163001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015868226
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1159/000280401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010071075
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1159/000402511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019984291
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1200/jco.1986.4.2.244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080047767
    387 rdf:type schema:CreativeWork
     




    Preview window. Press ESC to close (or click here)


    ...