Ajmalicine production by cell cultures of Catharanthus roseus: from shake flask to bioreactor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-09

AUTHORS

Hens J. G. ten Hoopen, Walter M. van Gulik, Jurriaan E. Schlatmann, Paulo R. H. Moreno, J. L. Vinke, J. J. Heijnen, Robert Verpoorte

ABSTRACT

The productivity of a cell culture for the production of a secondary metabolite is defined by three factors: specific growth rate, specific product formation rate, and biomass concentration during production. The effect of scaling-up from shake flask to bioreactor on growth and production and the effect of increasing the biomass concentration were investigated for the production of ajmalicine by Catharanthus roseus cell suspensions. Growth of biomass was not affected by the type of culture vessel. Growth, carbohydrate storage, glucose and oxygen consumption, and the carbon dioxide production could be predicted rather well by a structured model with the internal phosphate and the external glucose concentration as the controlling factors. The production of ajmalicine on production medium in a shake flask was not reproduced in a bioreactor. The production could be restored by creating a gas regime in the bioreactor comparable to that in a shake flask. Increasing the biomass concentration both in a shake flask and in a stirred fermenter decreased the ajmalicine production rate. This effect could be removed partly by controlling the oxygen concentration in the more dense culture at 85% air saturation. More... »

PAGES

85-91

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00033865

DOI

http://dx.doi.org/10.1007/bf00033865

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008820505


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0904", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Engineering", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/09", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Engineering", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Delft University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.5292.c", 
          "name": [
            "Biotechnology Delft Leiden, Project Group Plant Cell Biotechnology, Department of Biochemical Engineering, Delft University of Technology, Julianalaan 67, NL-2628 BC, Delft, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "ten Hoopen", 
        "givenName": "Hens J. G.", 
        "id": "sg:person.014516252143.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014516252143.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Delft University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.5292.c", 
          "name": [
            "Biotechnology Delft Leiden, Project Group Plant Cell Biotechnology, Department of Biochemical Engineering, Delft University of Technology, Julianalaan 67, NL-2628 BC, Delft, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Gulik", 
        "givenName": "Walter M.", 
        "id": "sg:person.0615715153.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615715153.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Delft University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.5292.c", 
          "name": [
            "Biotechnology Delft Leiden, Project Group Plant Cell Biotechnology, Department of Biochemical Engineering, Delft University of Technology, Julianalaan 67, NL-2628 BC, Delft, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schlatmann", 
        "givenName": "Jurriaan E.", 
        "id": "sg:person.011122500753.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011122500753.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Leiden University", 
          "id": "https://www.grid.ac/institutes/grid.5132.5", 
          "name": [
            "Division of Pharmacognosy, Leiden/Amsterdam Center for Drug research, Leiden University, P.O. Box 9502, NL-2300 RA, Leiden, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moreno", 
        "givenName": "Paulo R. H.", 
        "id": "sg:person.012410556612.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012410556612.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Delft University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.5292.c", 
          "name": [
            "Biotechnology Delft Leiden, Project Group Plant Cell Biotechnology, Department of Biochemical Engineering, Delft University of Technology, Julianalaan 67, NL-2628 BC, Delft, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vinke", 
        "givenName": "J. L.", 
        "id": "sg:person.0724024314.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724024314.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Delft University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.5292.c", 
          "name": [
            "Biotechnology Delft Leiden, Project Group Plant Cell Biotechnology, Department of Biochemical Engineering, Delft University of Technology, Julianalaan 67, NL-2628 BC, Delft, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heijnen", 
        "givenName": "J. J.", 
        "id": "sg:person.01026476151.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026476151.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Leiden University", 
          "id": "https://www.grid.ac/institutes/grid.5132.5", 
          "name": [
            "Division of Pharmacognosy, Leiden/Amsterdam Center for Drug research, Leiden University, P.O. Box 9502, NL-2300 RA, Leiden, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Verpoorte", 
        "givenName": "Robert", 
        "id": "sg:person.0607764165.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607764165.99"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/bit.260400802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007048730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bit.260330507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014181216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-3054.1965.tb06874.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016020981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01982832", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020207676", 
          "https://doi.org/10.1007/bf01982832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01982832", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020207676", 
          "https://doi.org/10.1007/bf01982832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bit.260410212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025585591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00043666", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027311775", 
          "https://doi.org/10.1007/bf00043666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00043666", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027311775", 
          "https://doi.org/10.1007/bf00043666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01030277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029600436", 
          "https://doi.org/10.1007/bf01030277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-73157-0_30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039042119", 
          "https://doi.org/10.1007/978-3-642-73157-0_30"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0099-9598(08)60268-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042777845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00166846", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044656504", 
          "https://doi.org/10.1007/bf00166846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bit.260410803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051383059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jxb/22.1.96", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059853582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jxb/37.12.1911", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059856114"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1994-09", 
    "datePublishedReg": "1994-09-01", 
    "description": "The productivity of a cell culture for the production of a secondary metabolite is defined by three factors: specific growth rate, specific product formation rate, and biomass concentration during production. The effect of scaling-up from shake flask to bioreactor on growth and production and the effect of increasing the biomass concentration were investigated for the production of ajmalicine by Catharanthus roseus cell suspensions. Growth of biomass was not affected by the type of culture vessel. Growth, carbohydrate storage, glucose and oxygen consumption, and the carbon dioxide production could be predicted rather well by a structured model with the internal phosphate and the external glucose concentration as the controlling factors. The production of ajmalicine on production medium in a shake flask was not reproduced in a bioreactor. The production could be restored by creating a gas regime in the bioreactor comparable to that in a shake flask. Increasing the biomass concentration both in a shake flask and in a stirred fermenter decreased the ajmalicine production rate. This effect could be removed partly by controlling the oxygen concentration in the more dense culture at 85% air saturation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf00033865", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1123614", 
        "issn": [
          "0167-6857", 
          "1573-5044"
        ], 
        "name": "Plant Cell, Tissue and Organ Culture (PCTOC)", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2-3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "38"
      }
    ], 
    "name": "Ajmalicine production by cell cultures of Catharanthus roseus: from shake flask to bioreactor", 
    "pagination": "85-91", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2a063cc21facc464057544c7769cb10094d6f4ec6dc1e1a4a8b94bd31bede46f"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00033865"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1008820505"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00033865", 
      "https://app.dimensions.ai/details/publication/pub.1008820505"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:54", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130811_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF00033865"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00033865'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00033865'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00033865'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00033865'


 

This table displays all metadata directly associated to this object as RDF triples.

150 TRIPLES      21 PREDICATES      40 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00033865 schema:about anzsrc-for:09
2 anzsrc-for:0904
3 schema:author N83eb0bff984f407eaffa522fe0eea558
4 schema:citation sg:pub.10.1007/978-3-642-73157-0_30
5 sg:pub.10.1007/bf00043666
6 sg:pub.10.1007/bf00166846
7 sg:pub.10.1007/bf01030277
8 sg:pub.10.1007/bf01982832
9 https://doi.org/10.1002/bit.260330507
10 https://doi.org/10.1002/bit.260400802
11 https://doi.org/10.1002/bit.260410212
12 https://doi.org/10.1002/bit.260410803
13 https://doi.org/10.1016/s0099-9598(08)60268-0
14 https://doi.org/10.1093/jxb/22.1.96
15 https://doi.org/10.1093/jxb/37.12.1911
16 https://doi.org/10.1111/j.1399-3054.1965.tb06874.x
17 schema:datePublished 1994-09
18 schema:datePublishedReg 1994-09-01
19 schema:description The productivity of a cell culture for the production of a secondary metabolite is defined by three factors: specific growth rate, specific product formation rate, and biomass concentration during production. The effect of scaling-up from shake flask to bioreactor on growth and production and the effect of increasing the biomass concentration were investigated for the production of ajmalicine by Catharanthus roseus cell suspensions. Growth of biomass was not affected by the type of culture vessel. Growth, carbohydrate storage, glucose and oxygen consumption, and the carbon dioxide production could be predicted rather well by a structured model with the internal phosphate and the external glucose concentration as the controlling factors. The production of ajmalicine on production medium in a shake flask was not reproduced in a bioreactor. The production could be restored by creating a gas regime in the bioreactor comparable to that in a shake flask. Increasing the biomass concentration both in a shake flask and in a stirred fermenter decreased the ajmalicine production rate. This effect could be removed partly by controlling the oxygen concentration in the more dense culture at 85% air saturation.
20 schema:genre research_article
21 schema:inLanguage en
22 schema:isAccessibleForFree false
23 schema:isPartOf N1664bd03bba84ed6b2767839dc41fa02
24 Nf24f93679dd84e528761b2c8cd5bad61
25 sg:journal.1123614
26 schema:name Ajmalicine production by cell cultures of Catharanthus roseus: from shake flask to bioreactor
27 schema:pagination 85-91
28 schema:productId N393dda4028fa4567827ad5b62052f962
29 N67ab5783400a45b6aedb0d7966c76d92
30 Na5f1c863d4ba4842b69338ae815f9882
31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008820505
32 https://doi.org/10.1007/bf00033865
33 schema:sdDatePublished 2019-04-11T13:54
34 schema:sdLicense https://scigraph.springernature.com/explorer/license/
35 schema:sdPublisher N9a732d95293148afa0704e3f62830304
36 schema:url http://link.springer.com/10.1007/BF00033865
37 sgo:license sg:explorer/license/
38 sgo:sdDataset articles
39 rdf:type schema:ScholarlyArticle
40 N14d840d6dd78421790687629baa5667c rdf:first sg:person.0724024314.36
41 rdf:rest N4fbed7b4bd7a4993b0d33764bfd4ed63
42 N1664bd03bba84ed6b2767839dc41fa02 schema:issueNumber 2-3
43 rdf:type schema:PublicationIssue
44 N393dda4028fa4567827ad5b62052f962 schema:name readcube_id
45 schema:value 2a063cc21facc464057544c7769cb10094d6f4ec6dc1e1a4a8b94bd31bede46f
46 rdf:type schema:PropertyValue
47 N4701ed7ff27f40578e79043f7b9e5122 rdf:first sg:person.0615715153.53
48 rdf:rest N751721d8818a4880a4b22549bb14a1b9
49 N4a2bcf6df44f48bcbb47ee9d17815ca6 rdf:first sg:person.0607764165.99
50 rdf:rest rdf:nil
51 N4fbed7b4bd7a4993b0d33764bfd4ed63 rdf:first sg:person.01026476151.36
52 rdf:rest N4a2bcf6df44f48bcbb47ee9d17815ca6
53 N64cdcebbb955433f9eef29ad75665caa rdf:first sg:person.012410556612.74
54 rdf:rest N14d840d6dd78421790687629baa5667c
55 N67ab5783400a45b6aedb0d7966c76d92 schema:name doi
56 schema:value 10.1007/bf00033865
57 rdf:type schema:PropertyValue
58 N751721d8818a4880a4b22549bb14a1b9 rdf:first sg:person.011122500753.57
59 rdf:rest N64cdcebbb955433f9eef29ad75665caa
60 N83eb0bff984f407eaffa522fe0eea558 rdf:first sg:person.014516252143.03
61 rdf:rest N4701ed7ff27f40578e79043f7b9e5122
62 N9a732d95293148afa0704e3f62830304 schema:name Springer Nature - SN SciGraph project
63 rdf:type schema:Organization
64 Na5f1c863d4ba4842b69338ae815f9882 schema:name dimensions_id
65 schema:value pub.1008820505
66 rdf:type schema:PropertyValue
67 Nf24f93679dd84e528761b2c8cd5bad61 schema:volumeNumber 38
68 rdf:type schema:PublicationVolume
69 anzsrc-for:09 schema:inDefinedTermSet anzsrc-for:
70 schema:name Engineering
71 rdf:type schema:DefinedTerm
72 anzsrc-for:0904 schema:inDefinedTermSet anzsrc-for:
73 schema:name Chemical Engineering
74 rdf:type schema:DefinedTerm
75 sg:journal.1123614 schema:issn 0167-6857
76 1573-5044
77 schema:name Plant Cell, Tissue and Organ Culture (PCTOC)
78 rdf:type schema:Periodical
79 sg:person.01026476151.36 schema:affiliation https://www.grid.ac/institutes/grid.5292.c
80 schema:familyName Heijnen
81 schema:givenName J. J.
82 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026476151.36
83 rdf:type schema:Person
84 sg:person.011122500753.57 schema:affiliation https://www.grid.ac/institutes/grid.5292.c
85 schema:familyName Schlatmann
86 schema:givenName Jurriaan E.
87 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011122500753.57
88 rdf:type schema:Person
89 sg:person.012410556612.74 schema:affiliation https://www.grid.ac/institutes/grid.5132.5
90 schema:familyName Moreno
91 schema:givenName Paulo R. H.
92 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012410556612.74
93 rdf:type schema:Person
94 sg:person.014516252143.03 schema:affiliation https://www.grid.ac/institutes/grid.5292.c
95 schema:familyName ten Hoopen
96 schema:givenName Hens J. G.
97 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014516252143.03
98 rdf:type schema:Person
99 sg:person.0607764165.99 schema:affiliation https://www.grid.ac/institutes/grid.5132.5
100 schema:familyName Verpoorte
101 schema:givenName Robert
102 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607764165.99
103 rdf:type schema:Person
104 sg:person.0615715153.53 schema:affiliation https://www.grid.ac/institutes/grid.5292.c
105 schema:familyName van Gulik
106 schema:givenName Walter M.
107 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615715153.53
108 rdf:type schema:Person
109 sg:person.0724024314.36 schema:affiliation https://www.grid.ac/institutes/grid.5292.c
110 schema:familyName Vinke
111 schema:givenName J. L.
112 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724024314.36
113 rdf:type schema:Person
114 sg:pub.10.1007/978-3-642-73157-0_30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039042119
115 https://doi.org/10.1007/978-3-642-73157-0_30
116 rdf:type schema:CreativeWork
117 sg:pub.10.1007/bf00043666 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027311775
118 https://doi.org/10.1007/bf00043666
119 rdf:type schema:CreativeWork
120 sg:pub.10.1007/bf00166846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044656504
121 https://doi.org/10.1007/bf00166846
122 rdf:type schema:CreativeWork
123 sg:pub.10.1007/bf01030277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029600436
124 https://doi.org/10.1007/bf01030277
125 rdf:type schema:CreativeWork
126 sg:pub.10.1007/bf01982832 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020207676
127 https://doi.org/10.1007/bf01982832
128 rdf:type schema:CreativeWork
129 https://doi.org/10.1002/bit.260330507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014181216
130 rdf:type schema:CreativeWork
131 https://doi.org/10.1002/bit.260400802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007048730
132 rdf:type schema:CreativeWork
133 https://doi.org/10.1002/bit.260410212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025585591
134 rdf:type schema:CreativeWork
135 https://doi.org/10.1002/bit.260410803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051383059
136 rdf:type schema:CreativeWork
137 https://doi.org/10.1016/s0099-9598(08)60268-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042777845
138 rdf:type schema:CreativeWork
139 https://doi.org/10.1093/jxb/22.1.96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059853582
140 rdf:type schema:CreativeWork
141 https://doi.org/10.1093/jxb/37.12.1911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059856114
142 rdf:type schema:CreativeWork
143 https://doi.org/10.1111/j.1399-3054.1965.tb06874.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016020981
144 rdf:type schema:CreativeWork
145 https://www.grid.ac/institutes/grid.5132.5 schema:alternateName Leiden University
146 schema:name Division of Pharmacognosy, Leiden/Amsterdam Center for Drug research, Leiden University, P.O. Box 9502, NL-2300 RA, Leiden, The Netherlands
147 rdf:type schema:Organization
148 https://www.grid.ac/institutes/grid.5292.c schema:alternateName Delft University of Technology
149 schema:name Biotechnology Delft Leiden, Project Group Plant Cell Biotechnology, Department of Biochemical Engineering, Delft University of Technology, Julianalaan 67, NL-2628 BC, Delft, The Netherlands
150 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...