Rapid Diagnostic Tests Show False Positive Leading to Dilemma in Malarial Treatment: A Case Study View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2015

AUTHORS

Amit Kumar , Susanta Kumar Panda

ABSTRACT

The absolute necessity for rational therapy in the face of rampant drug resistance places increasing importance on the accuracy of malaria diagnosis. Giemsa microscopy and Triple test method Rapid Diagnostic Test (RDT) represent the two diagnoses most likely to have the largest impact on malaria control in this present study. These two methods have their characteristic strengths and limitation. These tests were carried out on 156 patients of endemic areas of Gajapati district of Odisha State. These tests were evaluated by two methods, i.e. microscopic slide test and RDT kit method. RDT kits belong to Advantage MAL CARD Malaria pLDH (Plasmodium Lactate Dehydrogenase) antibody Pre-coated (J. Mitra & Co, India) card test, ParaHIT PfHRP2 (Histidine-Rich Protein 2) antibody pre-coated dip stick (Span Diagnostic Ltd, India) and S.D BIOLINE pf/pv capture antigen MSP (Merozoite Surface Protein) pre-coated card (S.D. BIO Standard Diagnostic Pvt. Ltd, India). A little amount of whole blood (5 μl) was taken using the plastic loop given with the kit, at the same time two slides are also taken. Out of 156 patients it was detected that 128 were negative and 28 were positive according to microscopic detection. Out of these 28 positives 23 were only P. falciparum, 2 were only P. vivax, 3 were having both PF and PV infection detected. On the other hand 32 were positive and 4 were false positive as shown by Advantage MAL CARD and ParaHIT, where as 49 were positive and 21 were false positive by the S.D. MSP pre-coated antigen card test kits. More... »

PAGES

73-79

References to SciGraph publications

  • 2006-09. Ensuring quality and access for malaria diagnosis: how can it be achieved? in NATURE REVIEWS MICROBIOLOGY
  • 2006-12. A guide for diagnostic evaluations in NATURE REVIEWS MICROBIOLOGY
  • Book

    TITLE

    Biotechnology and Bioforensics

    ISBN

    978-981-287-049-0
    978-981-287-050-6

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-981-287-050-6_8

    DOI

    http://dx.doi.org/10.1007/978-981-287-050-6_8

    DIMENSIONS

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