Health Benefits of Anti-aging Drugs. View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2019

AUTHORS

Veronika Piskovatska , Olha Strilbytska , Alexander Koliada , Alexander Vaiserman , Oleh Lushchak

ABSTRACT

Aging, as a physiological process mediated by numerous regulatory pathways and transcription factors, is manifested by continuous progressive functional decline and increasing risk of chronic diseases. There is an increasing interest to identify pharmacological agents for treatment and prevention of age-related disease in humans. Animal models play an important role in identification and testing of anti-aging compounds; this step is crucial before the drug will enter human clinical trial or will be introduced to human medicine. One of the main goals of animal studies is better understanding of mechanistic targets, therapeutic implications and side-effects of the drug, which may be later translated into humans. In this chapter, we summarized the effects of different drugs reported to extend the lifespan in model organisms from round worms to rodents. Resveratrol, rapamycin, metformin and aspirin, showing effectiveness in model organism life- and healthspan extension mainly target the master regulators of aging such as mTOR, FOXO and PGC1α, affecting autophagy, inflammation and oxidative stress. In humans, these drugs were demonstrated to reduce inflammation, prevent CVD, and slow down the functional decline in certain organs. Additionally, potential anti-aging pharmacologic agents inhibit cancerogenesis, interfering with certain aspects of cell metabolism, proliferation, angioneogenesis and apoptosis. More... »

PAGES

339-392

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  • Book

    TITLE

    Biochemistry and Cell Biology of Ageing: Part II Clinical Science

    ISBN

    978-981-13-3680-5
    978-981-13-3681-2

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-981-13-3681-2_13

    DOI

    http://dx.doi.org/10.1007/978-981-13-3681-2_13

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112861121

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30888659


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