Cutaneous Adverse Drug Reactions from Antituberculosis Treatment View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2018-10-20

AUTHORS

Jonny Peter , Rannakoe J. Lehloenya

ABSTRACT

Effective treatment for drug-sensitive TB remains a long, multidrug endeavor. Therapeutic complexity is increased by HIV coinfection (>60% of incident TB cases are co-infected in HIV/TB endemic settings) and the growing burden of multi- and extremely drug-resistant TB (MDR- and XDR-TB). CADRs are common adverse reactions in both drug-sensitive and resistant anti-TB regimens, and the majorities are delayed T-cell-mediated reactions. Individual anti-TB drugs cause different CADR phenotypes of varying severity, while SCAR phenotypes such as DRESS, SJS/TEN, and LDE have been associated with many chemically different anti-TB drugs. The key management challenges include (1) multiple possible offending drugs, with a lack of accurate diagnostic testing, (2) high TB-related mortality with prolonged treatment interruptions, and (3) not unnecessarily excluding effective non-culprit anti-TB drugs in CADR patients. We discuss the spectrum of anti-TB drug-associated CADRs and offending drugs, as well as the pragmatic utility of drug provocation testing to identify culprit drugs and minimize treatment interruptions. More... »

PAGES

207-215

References to SciGraph publications

Book

TITLE

Advances in Diagnosis and Management of Cutaneous Adverse Drug Reactions

ISBN

978-981-13-1488-9
978-981-13-1489-6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-981-13-1489-6_14

DOI

http://dx.doi.org/10.1007/978-981-13-1489-6_14

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107733146


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