Descriptive and Analytic Epidemiology of Idiopathic Normal Pressure Hydrocephalus (iNPH) in Japan View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2018-09-15

AUTHORS

Nagato Kuriyama , Masakazu Miyajima , Madoka Nakajima , Takeo Kato , Michiko Kurosawa , Wakaba Fukushima , Takahiko Tokuda , Yoshiyuki Watanabe , Etsuko Ozaki , Teruhide Koyama , Daisuke Matsui , Isao Watanabe , Hajime Arai

ABSTRACT

The two pillars of descriptive and analytic epidemiological studies on intractable diseases are clarification of the number of patients showing symptoms and basic clinical features. This report introduces the importance of descriptive and analytic epidemiology of intractable diseases with regard to the significance, methodology, and points of attention through a nationwide survey of idiopathic normal pressure hydrocephalus (iNPH) that we experienced including specific survey methods, with introduction of reports from Japan and other countries.iNPH manifests three features: gait disturbance, cognitive impairment, and urinary incontinence. The cerebrospinal fluid pressure is within the normal range although ventricular enlargement occurs, and symptoms can be improved by cerebrospinal fluid shunt treatment. It is more likely to develop in the elderly (60 years old or older), attracting attention as a geriatric disease of unknown cause with increasing number of patients. After the treatment guidelines were established, new epidemiological information has been accumulating in Japan. This nationwide hospital-based epidemiologic survey was performed based on patient’s background and clarified the presence of 13,000 patients treated for iNPH per year in Japan. In addition, comorbidities of iNPH included hypertension, diabetes, Alzheimer disease, and orthopedic diseases, and gender-specific characteristics were noted. Long-term treatment effect can be obtained by appropriate diagnosis and proper cerebrospinal fluid shunt operation. Utilization of the data collected by previous studies on iNPH reported in Japan and other countries including this nationwide survey is expected to elucidate the fundamental mechanism related to the cause and pathology of iNPH as a treatable disease of the elderly. More... »

PAGES

83-102

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-981-13-1096-6_6

DOI

http://dx.doi.org/10.1007/978-981-13-1096-6_6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106984097


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