Taurine Promotes Retinal Ganglion Cell Survival Through GABAB Receptor Activation View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2017-08-29

AUTHORS

Wahiba Hadj-Saïd , Valérie Fradot , Ivana Ivkovic , José-Alain Sahel , Serge Picaud , Nicolas Froger

ABSTRACT

Retinal ganglion cell (RGC) degeneration occurs in numerous retinal diseases, either as a primary process like in glaucoma, or secondary to photoreceptor loss and no efficient compound targeting directly RGC neuroprotection is yet available. We previously described that taurine exerts a direct protective effect on RGCs cultured under serum-deprived conditions. Because taurine was known to have an agonist-like activity for GABA/glycine receptors, we investigated here if the taurine-elicited neuroprotective effect may be mediated through the activation of these receptors using selective antagonist ligands. RGCs were purified, seeded in 96-well plate and maintained in culture during 6 days in vitro. Viable cells were labelled with calcein and densities in full-well area were then automatically counted. Here we show that the protective effect of taurine against RGC loss observed under serum deprivation can be mediated through the GABAB receptor stimulation. Hence, two selective agonists, including baclofen, at this metabotropic GABAB receptor were found to reproduce taurine action by enhancing RGC survival in culture. This study suggests that GABAB receptor stimulation provides direct neuroprotection for RGCs. Accordingly, drugs targeting GABAB receptor may represent a new way for the prevention of RGC degeneration. More... »

PAGES

687-701

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-024-1079-2_54

DOI

http://dx.doi.org/10.1007/978-94-024-1079-2_54

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091373311

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28849492


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "GABA-B Receptor Agonists", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuroprotective Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Long-Evans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, GABA-B", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retinal Ganglion Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Taurine", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "CNRS, UMR 7210, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "INSERM, U968, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
            "UPMC Univ Paris 06, UMR_S968, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
            "CNRS, UMR 7210, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hadj-Sa\u00efd", 
        "givenName": "Wahiba", 
        "id": "sg:person.0653617223.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653617223.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CNRS, UMR 7210, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "INSERM, U968, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
            "UPMC Univ Paris 06, UMR_S968, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
            "CNRS, UMR 7210, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fradot", 
        "givenName": "Val\u00e9rie", 
        "id": "sg:person.01052402103.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052402103.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CNRS, UMR 7210, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "INSERM, U968, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
            "UPMC Univ Paris 06, UMR_S968, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
            "CNRS, UMR 7210, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ivkovic", 
        "givenName": "Ivana", 
        "id": "sg:person.01273762576.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273762576.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Ophthalmology, University College of London, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "INSERM, U968, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
            "UPMC Univ Paris 06, UMR_S968, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
            "CNRS, UMR 7210, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
            "Centre Hospitalier National d\u2019Ophtalmologie des Quinze-Vingts, F-75012, Paris, France", 
            "Fondation Ophtalmologique Adolphe de Rothschild, F-75020, Paris, France", 
            "Institute of Ophthalmology, University College of London, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sahel", 
        "givenName": "Jos\u00e9-Alain", 
        "id": "sg:person.01104041722.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104041722.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Ophthalmology, University College of London, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "INSERM, U968, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
            "UPMC Univ Paris 06, UMR_S968, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
            "CNRS, UMR 7210, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
            "Institute of Ophthalmology, University College of London, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Picaud", 
        "givenName": "Serge", 
        "id": "sg:person.0642273724.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642273724.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CNRS, UMR 7210, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "INSERM, U968, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
            "UPMC Univ Paris 06, UMR_S968, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
            "CNRS, UMR 7210, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Froger", 
        "givenName": "Nicolas", 
        "id": "sg:person.01313723524.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313723524.99"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2017-08-29", 
    "datePublishedReg": "2017-08-29", 
    "description": "Retinal ganglion cell (RGC) degeneration occurs in numerous retinal diseases, either as a primary process like in glaucoma, or secondary to photoreceptor loss and no efficient compound targeting directly RGC neuroprotection is yet available. We previously described that taurine exerts a direct protective effect on RGCs cultured under serum-deprived conditions. Because taurine was known to have an agonist-like activity for GABA/glycine receptors, we investigated here if the taurine-elicited neuroprotective effect may be mediated through the activation of these receptors using selective antagonist ligands. RGCs were purified, seeded in 96-well plate and maintained in culture during 6 days in vitro. Viable cells were labelled with calcein and densities in full-well area were then automatically counted. Here we show that the protective effect of taurine against RGC loss observed under serum deprivation can be mediated through the GABAB receptor stimulation. Hence, two selective agonists, including baclofen, at this metabotropic GABAB receptor were found to reproduce taurine action by enhancing RGC survival in culture. This study suggests that GABAB receptor stimulation provides direct neuroprotection for RGCs. Accordingly, drugs targeting GABAB receptor may represent a new way for the prevention of RGC degeneration.", 
    "editor": [
      {
        "familyName": "Lee", 
        "givenName": "Dong-Hee", 
        "type": "Person"
      }, 
      {
        "familyName": "Schaffer", 
        "givenName": "Stephen W.", 
        "type": "Person"
      }, 
      {
        "familyName": "Park", 
        "givenName": "Eunkyue", 
        "type": "Person"
      }, 
      {
        "familyName": "Kim", 
        "givenName": "Ha Won", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-94-024-1079-2_54", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-94-024-1077-8", 
        "978-94-024-1079-2"
      ], 
      "name": "Taurine 10", 
      "type": "Book"
    }, 
    "keywords": [
      "GABAB receptor stimulation", 
      "GABAB receptors", 
      "protective effect", 
      "receptor stimulation", 
      "retinal ganglion cell survival", 
      "retinal ganglion cell degeneration", 
      "agonist-like activity", 
      "metabotropic GABAB receptors", 
      "ganglion cell survival", 
      "GABAB receptor activation", 
      "ganglion cell degeneration", 
      "direct protective effect", 
      "numerous retinal diseases", 
      "selective antagonist ligand", 
      "direct neuroprotection", 
      "RGC degeneration", 
      "RGC loss", 
      "RGC survival", 
      "neuroprotective effects", 
      "RGC neuroprotection", 
      "taurine action", 
      "selective agonist", 
      "glycine receptors", 
      "retinal diseases", 
      "receptor activation", 
      "cell degeneration", 
      "antagonist ligands", 
      "receptors", 
      "RGCs", 
      "neuroprotection", 
      "serum-deprived conditions", 
      "taurine", 
      "degeneration", 
      "cell survival", 
      "stimulation", 
      "serum deprivation", 
      "survival", 
      "viable cells", 
      "activation", 
      "baclofen", 
      "glaucoma", 
      "agonists", 
      "disease", 
      "prevention", 
      "drugs", 
      "efficient compounds", 
      "effect", 
      "days", 
      "deprivation", 
      "loss", 
      "culture", 
      "cells", 
      "activity", 
      "action", 
      "study", 
      "calcein", 
      "area", 
      "ligands", 
      "primary process", 
      "compounds", 
      "conditions", 
      "plate", 
      "density", 
      "process", 
      "new way", 
      "way", 
      "GABA/glycine receptors", 
      "taurine-elicited neuroprotective effect", 
      "full-well area", 
      "Taurine Promotes Retinal Ganglion Cell Survival", 
      "Promotes Retinal Ganglion Cell Survival"
    ], 
    "name": "Taurine Promotes Retinal Ganglion Cell Survival Through GABAB Receptor Activation", 
    "pagination": "687-701", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1091373311"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-94-024-1079-2_54"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28849492"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-94-024-1079-2_54", 
      "https://app.dimensions.ai/details/publication/pub.1091373311"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2021-11-01T18:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/chapter/chapter_366.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-94-024-1079-2_54"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-94-024-1079-2_54'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-94-024-1079-2_54'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-94-024-1079-2_54'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-94-024-1079-2_54'


 

This table displays all metadata directly associated to this object as RDF triples.

239 TRIPLES      23 PREDICATES      108 URIs      101 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-94-024-1079-2_54 schema:about N0ecee2f27e2f47e09fdea2624075a314
2 N10e5d18ebe1f4bd9aa6a987ff0805b90
3 N1ab6d94b8b014c9ba2c664e843dc7fee
4 N456bc1eeb51248c99771bc474546226c
5 N6505554aa81a4b4aac6ce88232de1f7f
6 N7dfed3a8b31e48f1968db9ab3404f504
7 N8d74ca018cbe45cc8a369015bcf3f864
8 N90ca50d1bc684fe19d3a0f48011c9f0c
9 N97c383ee0a9a40c3a015004e8826ead5
10 Nb5ed49d270f3427097e5bfe7095a9cd9
11 Ncbc5b414a2884716bd60ac83e3041e39
12 anzsrc-for:11
13 anzsrc-for:1115
14 schema:author N8e93a44a505d46748da61a6d1e38de40
15 schema:datePublished 2017-08-29
16 schema:datePublishedReg 2017-08-29
17 schema:description Retinal ganglion cell (RGC) degeneration occurs in numerous retinal diseases, either as a primary process like in glaucoma, or secondary to photoreceptor loss and no efficient compound targeting directly RGC neuroprotection is yet available. We previously described that taurine exerts a direct protective effect on RGCs cultured under serum-deprived conditions. Because taurine was known to have an agonist-like activity for GABA/glycine receptors, we investigated here if the taurine-elicited neuroprotective effect may be mediated through the activation of these receptors using selective antagonist ligands. RGCs were purified, seeded in 96-well plate and maintained in culture during 6 days in vitro. Viable cells were labelled with calcein and densities in full-well area were then automatically counted. Here we show that the protective effect of taurine against RGC loss observed under serum deprivation can be mediated through the GABAB receptor stimulation. Hence, two selective agonists, including baclofen, at this metabotropic GABAB receptor were found to reproduce taurine action by enhancing RGC survival in culture. This study suggests that GABAB receptor stimulation provides direct neuroprotection for RGCs. Accordingly, drugs targeting GABAB receptor may represent a new way for the prevention of RGC degeneration.
18 schema:editor N9141d690560f4ac98e64887a5f0504ee
19 schema:genre chapter
20 schema:inLanguage en
21 schema:isAccessibleForFree false
22 schema:isPartOf N613882537f8f4a77982b304953a69dfa
23 schema:keywords GABA/glycine receptors
24 GABAB receptor activation
25 GABAB receptor stimulation
26 GABAB receptors
27 Promotes Retinal Ganglion Cell Survival
28 RGC degeneration
29 RGC loss
30 RGC neuroprotection
31 RGC survival
32 RGCs
33 Taurine Promotes Retinal Ganglion Cell Survival
34 action
35 activation
36 activity
37 agonist-like activity
38 agonists
39 antagonist ligands
40 area
41 baclofen
42 calcein
43 cell degeneration
44 cell survival
45 cells
46 compounds
47 conditions
48 culture
49 days
50 degeneration
51 density
52 deprivation
53 direct neuroprotection
54 direct protective effect
55 disease
56 drugs
57 effect
58 efficient compounds
59 full-well area
60 ganglion cell degeneration
61 ganglion cell survival
62 glaucoma
63 glycine receptors
64 ligands
65 loss
66 metabotropic GABAB receptors
67 neuroprotection
68 neuroprotective effects
69 new way
70 numerous retinal diseases
71 plate
72 prevention
73 primary process
74 process
75 protective effect
76 receptor activation
77 receptor stimulation
78 receptors
79 retinal diseases
80 retinal ganglion cell degeneration
81 retinal ganglion cell survival
82 selective agonist
83 selective antagonist ligand
84 serum deprivation
85 serum-deprived conditions
86 stimulation
87 study
88 survival
89 taurine
90 taurine action
91 taurine-elicited neuroprotective effect
92 viable cells
93 way
94 schema:name Taurine Promotes Retinal Ganglion Cell Survival Through GABAB Receptor Activation
95 schema:pagination 687-701
96 schema:productId N38872e766e624e6ebd973eb976b121f2
97 N771e281e1b7c49b697886091caa38bb7
98 N7f3f680a44ce4cb5869b6b3b4825179f
99 schema:publisher Nfdc2b5d180f54badb77d41aa0eddf12c
100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091373311
101 https://doi.org/10.1007/978-94-024-1079-2_54
102 schema:sdDatePublished 2021-11-01T18:57
103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
104 schema:sdPublisher N3ce471ebee4d478c9f524b43a7b63a62
105 schema:url https://doi.org/10.1007/978-94-024-1079-2_54
106 sgo:license sg:explorer/license/
107 sgo:sdDataset chapters
108 rdf:type schema:Chapter
109 N099c089435314360965a2a8a3bacf183 schema:familyName Kim
110 schema:givenName Ha Won
111 rdf:type schema:Person
112 N0ecee2f27e2f47e09fdea2624075a314 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Rats, Long-Evans
114 rdf:type schema:DefinedTerm
115 N0fd2dba4c14c4ed4ad78085e85d1ad4a rdf:first sg:person.0642273724.04
116 rdf:rest N657fbf79cb63488cab13c60575384006
117 N10e5d18ebe1f4bd9aa6a987ff0805b90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Cells, Cultured
119 rdf:type schema:DefinedTerm
120 N1ab6d94b8b014c9ba2c664e843dc7fee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Male
122 rdf:type schema:DefinedTerm
123 N1c3f6b62a2914463a7f2e84d9e5f1188 rdf:first sg:person.01052402103.26
124 rdf:rest Nb431526275904690ba2b8a8a584fafb4
125 N3812f4fe150f43dc8bd3427ef270c0c7 rdf:first Nfd67cf6542c34bd8b62a3d087da049e5
126 rdf:rest N84bc8b114d064281b616d245857947c1
127 N38872e766e624e6ebd973eb976b121f2 schema:name dimensions_id
128 schema:value pub.1091373311
129 rdf:type schema:PropertyValue
130 N3ce471ebee4d478c9f524b43a7b63a62 schema:name Springer Nature - SN SciGraph project
131 rdf:type schema:Organization
132 N3ec56a393f764d948330b3ebaf67fbb9 rdf:first sg:person.01104041722.66
133 rdf:rest N0fd2dba4c14c4ed4ad78085e85d1ad4a
134 N456bc1eeb51248c99771bc474546226c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Receptors, GABA-B
136 rdf:type schema:DefinedTerm
137 N46f51b55e2cc49cfa7515440d5845eb9 schema:familyName Lee
138 schema:givenName Dong-Hee
139 rdf:type schema:Person
140 N5bd59c5dcccf45d094a85823df4b8a76 rdf:first N92ee58e4726b40f58bbdf2941698a1c9
141 rdf:rest N3812f4fe150f43dc8bd3427ef270c0c7
142 N613882537f8f4a77982b304953a69dfa schema:isbn 978-94-024-1077-8
143 978-94-024-1079-2
144 schema:name Taurine 10
145 rdf:type schema:Book
146 N6505554aa81a4b4aac6ce88232de1f7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Taurine
148 rdf:type schema:DefinedTerm
149 N657fbf79cb63488cab13c60575384006 rdf:first sg:person.01313723524.99
150 rdf:rest rdf:nil
151 N771e281e1b7c49b697886091caa38bb7 schema:name pubmed_id
152 schema:value 28849492
153 rdf:type schema:PropertyValue
154 N7dfed3a8b31e48f1968db9ab3404f504 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Rats
156 rdf:type schema:DefinedTerm
157 N7f3f680a44ce4cb5869b6b3b4825179f schema:name doi
158 schema:value 10.1007/978-94-024-1079-2_54
159 rdf:type schema:PropertyValue
160 N84bc8b114d064281b616d245857947c1 rdf:first N099c089435314360965a2a8a3bacf183
161 rdf:rest rdf:nil
162 N8d74ca018cbe45cc8a369015bcf3f864 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name GABA-B Receptor Agonists
164 rdf:type schema:DefinedTerm
165 N8e93a44a505d46748da61a6d1e38de40 rdf:first sg:person.0653617223.56
166 rdf:rest N1c3f6b62a2914463a7f2e84d9e5f1188
167 N90ca50d1bc684fe19d3a0f48011c9f0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Retinal Ganglion Cells
169 rdf:type schema:DefinedTerm
170 N9141d690560f4ac98e64887a5f0504ee rdf:first N46f51b55e2cc49cfa7515440d5845eb9
171 rdf:rest N5bd59c5dcccf45d094a85823df4b8a76
172 N92ee58e4726b40f58bbdf2941698a1c9 schema:familyName Schaffer
173 schema:givenName Stephen W.
174 rdf:type schema:Person
175 N97c383ee0a9a40c3a015004e8826ead5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Animals
177 rdf:type schema:DefinedTerm
178 Nb431526275904690ba2b8a8a584fafb4 rdf:first sg:person.01273762576.69
179 rdf:rest N3ec56a393f764d948330b3ebaf67fbb9
180 Nb5ed49d270f3427097e5bfe7095a9cd9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Cell Survival
182 rdf:type schema:DefinedTerm
183 Ncbc5b414a2884716bd60ac83e3041e39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Neuroprotective Agents
185 rdf:type schema:DefinedTerm
186 Nfd67cf6542c34bd8b62a3d087da049e5 schema:familyName Park
187 schema:givenName Eunkyue
188 rdf:type schema:Person
189 Nfdc2b5d180f54badb77d41aa0eddf12c schema:name Springer Nature
190 rdf:type schema:Organisation
191 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
192 schema:name Medical and Health Sciences
193 rdf:type schema:DefinedTerm
194 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
195 schema:name Pharmacology and Pharmaceutical Sciences
196 rdf:type schema:DefinedTerm
197 sg:person.01052402103.26 schema:affiliation grid-institutes:grid.4444.0
198 schema:familyName Fradot
199 schema:givenName Valérie
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052402103.26
201 rdf:type schema:Person
202 sg:person.01104041722.66 schema:affiliation grid-institutes:grid.83440.3b
203 schema:familyName Sahel
204 schema:givenName José-Alain
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104041722.66
206 rdf:type schema:Person
207 sg:person.01273762576.69 schema:affiliation grid-institutes:grid.4444.0
208 schema:familyName Ivkovic
209 schema:givenName Ivana
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273762576.69
211 rdf:type schema:Person
212 sg:person.01313723524.99 schema:affiliation grid-institutes:grid.4444.0
213 schema:familyName Froger
214 schema:givenName Nicolas
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313723524.99
216 rdf:type schema:Person
217 sg:person.0642273724.04 schema:affiliation grid-institutes:grid.83440.3b
218 schema:familyName Picaud
219 schema:givenName Serge
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642273724.04
221 rdf:type schema:Person
222 sg:person.0653617223.56 schema:affiliation grid-institutes:grid.4444.0
223 schema:familyName Hadj-Saïd
224 schema:givenName Wahiba
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653617223.56
226 rdf:type schema:Person
227 grid-institutes:grid.4444.0 schema:alternateName CNRS, UMR 7210, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France
228 schema:name CNRS, UMR 7210, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France
229 INSERM, U968, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France
230 UPMC Univ Paris 06, UMR_S968, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France
231 rdf:type schema:Organization
232 grid-institutes:grid.83440.3b schema:alternateName Institute of Ophthalmology, University College of London, London, UK
233 schema:name CNRS, UMR 7210, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France
234 Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts, F-75012, Paris, France
235 Fondation Ophtalmologique Adolphe de Rothschild, F-75020, Paris, France
236 INSERM, U968, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France
237 Institute of Ophthalmology, University College of London, London, UK
238 UPMC Univ Paris 06, UMR_S968, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France
239 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...