Ontology type: schema:Chapter
2015
AUTHORSVaishali Pannu , Padmashree C. G. Rida , Ritu Aneja
ABSTRACTKifC1/HSET is a kinesin-14 motor protein recently recognized as a crucial player in the bi-focal clustering of supernumerary centrosomes in human cancer cells during mitosis. Various threads of evidence also implicate HSET as a potential driver of tumor evolution, with overexpression resulting in the emergence of more aggressive traits in tumors. Since HSET function appears to be dispensable for the viability of healthy somatic cells, these observations raise the tantalizing possibility that targeting HSET might be a promising cancer-selective chemotherapeutic approach. In this chapter, we summarize the multiple cellular roles played by HSET in various model systems and enumerate the steps required to validate and develop HSET as an anti-cancer drug target. More... »
PAGES101-116
Kinesins and Cancer
ISBN
978-94-017-9731-3
978-94-017-9732-0
http://scigraph.springernature.com/pub.10.1007/978-94-017-9732-0_7
DOIhttp://dx.doi.org/10.1007/978-94-017-9732-0_7
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