The Human Kinesin-14 Motor KifC1/HSET Is an Attractive Anti-cancer Drug Target View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2015

AUTHORS

Vaishali Pannu , Padmashree C. G. Rida , Ritu Aneja

ABSTRACT

KifC1/HSET is a kinesin-14 motor protein recently recognized as a crucial player in the bi-focal clustering of supernumerary centrosomes in human cancer cells during mitosis. Various threads of evidence also implicate HSET as a potential driver of tumor evolution, with overexpression resulting in the emergence of more aggressive traits in tumors. Since HSET function appears to be dispensable for the viability of healthy somatic cells, these observations raise the tantalizing possibility that targeting HSET might be a promising cancer-selective chemotherapeutic approach. In this chapter, we summarize the multiple cellular roles played by HSET in various model systems and enumerate the steps required to validate and develop HSET as an anti-cancer drug target. More... »

PAGES

101-116

Book

TITLE

Kinesins and Cancer

ISBN

978-94-017-9731-3
978-94-017-9732-0

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-017-9732-0_7

DOI

http://dx.doi.org/10.1007/978-94-017-9732-0_7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030240470


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