Sarcomas View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2014

AUTHORS

Armen Parsyan , James L. Chen , Raphael Pollock , Sarkis Meterissian

ABSTRACT

Sarcomas, as opposed to carcinoma, are rare forms of human cancer comprising less than 1 % of adult cancers. While represented by a broad range of entities, sarcomas share a common ground that is a mesenchymal origin of the tumors. With the understanding of these various types of sarcomas at the molecular level recently gaining its momentum, the role of translation in the pathobiology of this group of diseases started to uncover, pointing at a common theme: the activation of the mTOR pathway with subsequent derepression of the function of eIF4E via 4E-BPs and the activation of the proproliferative translation program. In this chapter, we, for the first time, summarize the current knowledge regarding translation, its regulation, as well as diagnostic and therapeutic potential in various types of sarcomas. More... »

PAGES

453-466

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  • Book

    TITLE

    Translation and Its Regulation in Cancer Biology and Medicine

    ISBN

    978-94-017-9077-2
    978-94-017-9078-9

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-94-017-9078-9_22

    DOI

    http://dx.doi.org/10.1007/978-94-017-9078-9_22

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048016437


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