Wnt Pathway at a Glance: From the Deep of the Crypts to the Current Ways of Targeting View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2014

AUTHORS

Antonio Barbáchano , María Jesús Larriba , Gemma Ferrer-Mayorga , Alberto Muñoz , José Manuel González-Sancho

ABSTRACT

Wnt/β-catenin signalling pathway is crucial for the formation of many tissues and organs during development. In recent years, this pathway has also been found to regulate the biology of stem cells in the intestine and probably in other organs in adult life. Abnormal activation of Wnt/β-catenin signalling, which controls the expression of a high number of genes, is critical for the initiation and progression of most colorectal cancers. In line with this, the gene expression signature induced by activation of the Wnt/β-catenin pathway defines the intestinal stem cells present at the bottom of the crypts and also colon cancer stem cells. This supports the importance of inhibitors of the Wnt/β-catenin pathway as potential agents in colorectal cancer therapy. However, the complexity, wide activity in the organism modulating the biology of several cell types, and characteristics of this pathway have delayed the identification of suitable targets and so, the development of such inhibitors that are only now reaching the clinic. More... »

PAGES

85-106

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  • Book

    TITLE

    Stem Cells in Cancer: Should We Believe or Not?

    ISBN

    978-94-017-8753-6
    978-94-017-8754-3

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-94-017-8754-3_4

    DOI

    http://dx.doi.org/10.1007/978-94-017-8754-3_4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1012575288


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