2002
AUTHORSL. Erickson , W-J. Yu , T. Tuboly , E. Nagy , A. Bailey , J. Zhang , D. Yoo , S. Du
ABSTRACTEdible vaccines derived from plants offer clear advantages to the livestock industry with respect to cost and ease of delivery. From a consumer perspective, the widespread adoption by the industry of efficient, low-cost, edible plant-based vaccines offers the prospect of reduced exposure to animal pathogens in food products, as well as in the water supply. A major obstacle encountered in the initial development of plant-based vaccines has been the very low levels of antigens expressed in transgenic plants. Some of the strategies adopted to meet this obstacle include synthetic forms of the antigen genes, fusion proteins and inducible expression systems. However, even with augmented levels of antigen in plant tissue, a successful edible vaccine in plants will probably require in addition strategies for reducing degradation in the gut and enhancing immunogenicity. It may even be possible to develop DNA-based vaccines in plants. More... »
PAGES339-367
Molecular Farming of Plants and Animals for Human and Veterinary Medicine
ISBN
978-90-481-6110-2
978-94-017-2317-6
http://scigraph.springernature.com/pub.10.1007/978-94-017-2317-6_15
DOIhttp://dx.doi.org/10.1007/978-94-017-2317-6_15
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1012237929
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/07",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Agricultural and Veterinary Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0607",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Plant Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0703",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Crop and Pasture Production",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Plant Agriculture, Ontario Agricultural College, University of Guelph, N1G 2W1, Guelph, Ontario, Canada",
"id": "http://www.grid.ac/institutes/grid.34429.38",
"name": [
"Department of Plant Agriculture, Ontario Agricultural College, University of Guelph, N1G 2W1, Guelph, Ontario, Canada"
],
"type": "Organization"
},
"familyName": "Erickson",
"givenName": "L.",
"id": "sg:person.01031444506.39",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031444506.39"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Plant Agriculture, Ontario Agricultural College, University of Guelph, N1G 2W1, Guelph, Ontario, Canada",
"id": "http://www.grid.ac/institutes/grid.34429.38",
"name": [
"Department of Plant Agriculture, Ontario Agricultural College, University of Guelph, N1G 2W1, Guelph, Ontario, Canada"
],
"type": "Organization"
},
"familyName": "Yu",
"givenName": "W-J.",
"id": "sg:person.0732347556.82",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732347556.82"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Microbiology and Infectious Diseases, University of Veterinary Sciences, Budapest, Hungary",
"id": "http://www.grid.ac/institutes/grid.483037.b",
"name": [
"Department of Pathobiology, Ontario Veterinary College, University of Guelph, N1G 2W1, Guelph, Ontario, Canada",
"Department of Microbiology and Infectious Diseases, University of Veterinary Sciences, Budapest, Hungary"
],
"type": "Organization"
},
"familyName": "Tuboly",
"givenName": "T.",
"id": "sg:person.01211722567.13",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211722567.13"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathobiology, Ontario Veterinary College, University of Guelph, N1G 2W1, Guelph, Ontario, Canada",
"id": "http://www.grid.ac/institutes/grid.34429.38",
"name": [
"Department of Pathobiology, Ontario Veterinary College, University of Guelph, N1G 2W1, Guelph, Ontario, Canada"
],
"type": "Organization"
},
"familyName": "Nagy",
"givenName": "E.",
"id": "sg:person.01325007256.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325007256.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Plant Agriculture, Ontario Agricultural College, University of Guelph, N1G 2W1, Guelph, Ontario, Canada",
"id": "http://www.grid.ac/institutes/grid.34429.38",
"name": [
"Department of Plant Agriculture, Ontario Agricultural College, University of Guelph, N1G 2W1, Guelph, Ontario, Canada"
],
"type": "Organization"
},
"familyName": "Bailey",
"givenName": "A.",
"id": "sg:person.01000462756.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000462756.66"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Plant Agriculture, Ontario Agricultural College, University of Guelph, N1G 2W1, Guelph, Ontario, Canada",
"id": "http://www.grid.ac/institutes/grid.34429.38",
"name": [
"Department of Plant Agriculture, Ontario Agricultural College, University of Guelph, N1G 2W1, Guelph, Ontario, Canada"
],
"type": "Organization"
},
"familyName": "Zhang",
"givenName": "J.",
"id": "sg:person.0722544546.44",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722544546.44"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathobiology, Ontario Veterinary College, University of Guelph, N1G 2W1, Guelph, Ontario, Canada",
"id": "http://www.grid.ac/institutes/grid.34429.38",
"name": [
"Department of Pathobiology, Ontario Veterinary College, University of Guelph, N1G 2W1, Guelph, Ontario, Canada"
],
"type": "Organization"
},
"familyName": "Yoo",
"givenName": "D.",
"id": "sg:person.0777472563.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777472563.30"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Plant Agriculture, Ontario Agricultural College, University of Guelph, N1G 2W1, Guelph, Ontario, Canada",
"id": "http://www.grid.ac/institutes/grid.34429.38",
"name": [
"Department of Plant Agriculture, Ontario Agricultural College, University of Guelph, N1G 2W1, Guelph, Ontario, Canada"
],
"type": "Organization"
},
"familyName": "Du",
"givenName": "S.",
"id": "sg:person.0771677701.81",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771677701.81"
],
"type": "Person"
}
],
"datePublished": "2002",
"datePublishedReg": "2002-01-01",
"description": "Edible vaccines derived from plants offer clear advantages to the livestock industry with respect to cost and ease of delivery. From a consumer perspective, the widespread adoption by the industry of efficient, low-cost, edible plant-based vaccines offers the prospect of reduced exposure to animal pathogens in food products, as well as in the water supply. A major obstacle encountered in the initial development of plant-based vaccines has been the very low levels of antigens expressed in transgenic plants. Some of the strategies adopted to meet this obstacle include synthetic forms of the antigen genes, fusion proteins and inducible expression systems. However, even with augmented levels of antigen in plant tissue, a successful edible vaccine in plants will probably require in addition strategies for reducing degradation in the gut and enhancing immunogenicity. It may even be possible to develop DNA-based vaccines in plants.",
"editor": [
{
"familyName": "Erickson",
"givenName": "L.",
"type": "Person"
},
{
"familyName": "Yu",
"givenName": "W.-J.",
"type": "Person"
},
{
"familyName": "Brandle",
"givenName": "J.",
"type": "Person"
},
{
"familyName": "Rymerson",
"givenName": "R.",
"type": "Person"
}
],
"genre": "chapter",
"id": "sg:pub.10.1007/978-94-017-2317-6_15",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": {
"isbn": [
"978-90-481-6110-2",
"978-94-017-2317-6"
],
"name": "Molecular Farming of Plants and Animals for Human and Veterinary Medicine",
"type": "Book"
},
"keywords": [
"plant-based vaccines",
"edible vaccines",
"livestock industry",
"livestock pathogens",
"transgenic plants",
"inducible expression system",
"animal pathogens",
"plant tissues",
"plants",
"water supply",
"expression system",
"food products",
"fusion protein",
"DNA-based vaccines",
"ease of delivery",
"widespread adoption",
"pathogens",
"antigen gene",
"vaccine",
"levels of antigen",
"initial development",
"synthetic form",
"industry",
"low levels",
"genes",
"supply",
"adoption",
"protein",
"reduced exposure",
"major obstacle",
"consumer perspective",
"strategies",
"addition strategy",
"clear advantage",
"gut",
"prospects",
"levels",
"tissue",
"degradation",
"products",
"cost",
"antigen",
"development",
"immunogenicity",
"exposure",
"obstacles",
"form",
"system",
"advantages",
"respect",
"ease",
"perspective",
"delivery"
],
"name": "Edible Vaccines in Plants for Livestock Pathogens",
"pagination": "339-367",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1012237929"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/978-94-017-2317-6_15"
]
}
],
"publisher": {
"name": "Springer Nature",
"type": "Organisation"
},
"sameAs": [
"https://doi.org/10.1007/978-94-017-2317-6_15",
"https://app.dimensions.ai/details/publication/pub.1012237929"
],
"sdDataset": "chapters",
"sdDatePublished": "2022-05-20T07:46",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/chapter/chapter_340.jsonl",
"type": "Chapter",
"url": "https://doi.org/10.1007/978-94-017-2317-6_15"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-94-017-2317-6_15'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-94-017-2317-6_15'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-94-017-2317-6_15'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-94-017-2317-6_15'
This table displays all metadata directly associated to this object as RDF triples.
191 TRIPLES
23 PREDICATES
81 URIs
72 LITERALS
7 BLANK NODES