Polarity and Bile Canaliculi-Like Channels in Self-Assembled Rat Hepatocyte Spheroids View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2002

AUTHORS

S. F. Abu-Absi , J. R. Friend , L. K. Hansen , W.-S. Hu

ABSTRACT

Rat hepatocytes, when cultured on moderately-adhesive substrates or in suspension, self-assemble into three dimensional, compacted, spherical aggregates called spheroids [1, 2]. In addition to maintaining higher liver-specific functions than monolayer cultures, spheroids bear structural similarity to native liver tissue. The surface of the spheroid is smooth, and cell-cell borders are barely distinguishable. In addition, pores are present on the surface of the spheroid and adjacent hepatocytes inside share microvilli-lined channels demarcated by tight junctions [3, 4]. Such differentiated structures are often indicative of hepatocyte polarization, the segregation of specific proteins to defined membrane domains. More... »

PAGES

241-246

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-017-0728-2_43

DOI

http://dx.doi.org/10.1007/978-94-017-0728-2_43

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012865909


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