T-Cell Dynamics and Renewal in HIV-1 Infection View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2000

AUTHORS

Dawn R. Clark , Katja C. Wolthers

ABSTRACT

The mechanism for CD4+ T-cell decline, one of the most prominent features of HIV-1 infection, is still not properly understood. Over the past 10 years of AIDS research, investigators have examined virus-related killing, apoptosis, and disturbed renewal capacity as possible mechanisms for CD4+ T-cell depletion [1–3]. In 1995 these possibilities were linked as two sides of the same coin, namely “turnover” of T cells. Now, the extent of turnover in T cells and its role in HIV-1 pathogenesis is a point of debate [4]. In this chapter, an overview is presented of our current knowledge on T-cell turnover and renewal in HIV-1 infection and the implications for CD4+ T-cell depletion. More... »

PAGES

55-64

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-017-0685-8_4

DOI

http://dx.doi.org/10.1007/978-94-017-0685-8_4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003729818


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