B — Non-Human Primate Models for HIV-1 Infection View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2000

AUTHORS

Norman L. Letvin

ABSTRACT

The only animal species readily infectable with HIV-1 is the chimpanzee. However, following infection with most HIV-1 isolates, chimpanzees do not develop disease [28]. Infection with some HIV-1 isolates results in seroconversion, but barely detectable plasma viral RNA. In these infected animals, virus isolations from peripheral blood are achievable only for a few weeks following HIV-1 inoculation [29]. Infection with other HIV-1 isolates results in a more intense viraemia with readily measurable viral RNA in the plasma and persistantly isolatable virus from the peripheral blood. However, the extent of viral replication in vivo with any of these usual HIV-1 isolates appears to decline over the first months following infection, resulting in an infectious process with a low level of viral replication and no disease pathogenesis. More... »

PAGES

279-282

Book

TITLE

AIDS Pathogenesis

ISBN

978-90-481-5407-4
978-94-017-0685-8

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-017-0685-8_17

DOI

http://dx.doi.org/10.1007/978-94-017-0685-8_17

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050933772


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