The Mechanisms of Metal Carcinogenicity View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1997

AUTHORS

Diane M. Stearns , Karen E. Wetterhahn

ABSTRACT

Metal carcinogens may act through both genotoxic and non-genotoxic pathways. Chromium(VI) (Cr(VI)) is an example of a genotoxic metal carcinogen. People can be exposed to Cr(VI) in the environment, from chromium-contaminated lands, and workers can be exposed in occupations that produce, refine, or use Cr(VI), for example in the manufacture of stainless steel, paints and pigments; and in chrome plating, leather tanning, and wood preserving industries. Toxic effects of acute exposure to Cr(VI) include perforation of the nasal septum, ulcerations of the skin, and contact dermatitis. Exposure of human populations to chronic high levels of Cr(VI) has been correlated with an increased incidence of lung cancer [1]. More... »

PAGES

55-72

Book

TITLE

Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment

ISBN

978-94-010-6440-8
978-94-011-5780-3

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-011-5780-3_4

DOI

http://dx.doi.org/10.1007/978-94-011-5780-3_4

DIMENSIONS

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