Solution Conformations By NMR of Novel Peptides Related to Cell Wall Peptidoglycan View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1997

AUTHORS

L. Szilágyi , T. E. Gunda , Đ. Ljevaković , B. Vranešić , J. Tomašić , V. šporec

ABSTRACT

Peptidoglycans, the ubiquitous constituents of bacterial cell walls, exhibit versatile biological activities including immunomodulating properties. We have synthesized novel derivatives of peptidoglycan monomer (PGM) 1 (R1-L-Ala-D-iGln-m-Dap(R2)-D-Ala-D-Ala, R1 = GlcNAc-MurNAc, R2 = H) with attached adamant-2-yl (Ad) residues: Ad-CH2CO-PGM 2 (Ad-PGM, R1 = GlcNAc-MurNAc, R2 = Ad) and the corresponding Ad-CH2CO-pentapeptide 3 (Ad-PP, R1 = H, R2 = Ad). Attachement of a bulky adamantyl group may, in principle, introduce conformational restraints into the PGM molecule and the pentapeptide derived thereof. We have therefore investigated the conformational properties of 2 and 3, using 2D NMR spectroscopy and molecular modelling, for solutions in DMSO. More... »

PAGES

33-34

Book

TITLE

Spectroscopy of Biological Molecules: Modern Trends

ISBN

978-94-010-6369-2
978-94-011-5622-6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-011-5622-6_15

DOI

http://dx.doi.org/10.1007/978-94-011-5622-6_15

DIMENSIONS

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