Cyclooxygenase-2 and intestinal cancer View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1996

AUTHORS

R. N. Dubois , A. Radhika , J. Shao , M. Tsujii , H. Sheng , O. Kobyashi , R. D. Beauchamp , C. S. Williams

ABSTRACT

Multiple epidemiological studies reveal a 40–50% reduction in mortality from colorectal cancer in individuals taking non-steroid anti-inflammatory drugs (NSAIDs) on a regular basis compared with those not taking these agents1–6. Persons with familial adenomatous polyposis (FAP) who take sulindac show a striking reduction in adenoma size and number7–11. In rodent models of azoxymethane-induced colorectal carcinogenesis, cyclooxygenase (COX) inhibitors exhibit chemoprotective effects as judged by a reduction in the frequency and number of premalignant and malignant lesions12–24 Recently, Jacoby et al.15 reported a decrease in tumour number in Min (multiple intestinal neoplasia) mice treated with piroxicam. More... »

PAGES

125-130

Book

TITLE

New Targets in Inflammation

ISBN

978-94-010-6265-7
978-94-011-5386-7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-011-5386-7_14

DOI

http://dx.doi.org/10.1007/978-94-011-5386-7_14

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004884195


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