DNA Injuries, Damage Induction and Removal View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1999

AUTHORS

B. D. Michael , G. Ronto , C. Baumstark-Khan , J. Cadet , M. Frankenberg-Schwager , O. V. Komova , W.-U. Müller , M. R. Quastel , E. Sage

ABSTRACT

Most of the physical and chemical processes involved in DNA damage induction have been characterized in general terms, both for UV and for ionizing radiations. The relative contributions of direct energy absorption and of indirect damage via reactive intermediates are broadly understood. Thus we have a general, although incomplete, picture of the influence of radiation type (wavelength for UV; quality or linear energy transfer (LET) for ionizing radiations) on biological outcome. Some aspects of the dose-effect relationships for DNA damage induction and of the kinetics of its repair are understood. These relationships provide key information for the development of mechanistic models of human risk/exposure relationships. More... »

PAGES

173-178

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-011-4585-5_23

DOI

http://dx.doi.org/10.1007/978-94-011-4585-5_23

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017046315


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