1991
AUTHORSKathryn F. McGonigle , George R. Huggins
ABSTRACTCombined estrogen-progestogen oral contraceptives (OC) have been in use since 1960 and current estimates of worldwide use are 55–56 million women [1]. Such widespread use must be justified by a favorable risk/benefit ratio. Experimental evidence supports a role for hormones in breast disease [2–8], and animal studies have suggested that estrogens and progestogens may play a role in breast cancer [9–13]. Estrogens and progestogens are also known to affect the risk of cancer in other hormone-responsive tissues and while OC clearly decreases the risk of endometrial and ovarian cancers [14,15], estrogen unopposed by progestogen increases the risk of endometrial cancer [16,17]. More... »
PAGES73-95
Approaches to Breast Cancer Prevention
ISBN
978-94-010-5664-9
978-94-011-3742-3
http://scigraph.springernature.com/pub.10.1007/978-94-011-3742-3_6
DOIhttp://dx.doi.org/10.1007/978-94-011-3742-3_6
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