Lymphocyte functional analysis in HIV infection: mechanisms and clinical relevance View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1992

AUTHORS

R. A. Gruters , F. Miedema

ABSTRACT

Acquired immunodeficiency syndrome (AIDS) is the collective name for many disease manifestations in the final stages of an infection with the human immunodeficiency virus (HIV)1. Development of disease is associated with a severe depletion of CD4+ T cells2, 3, which have been shown to be the main target for HIV4–6. The central role of T-helper cells with this CD4+ phenotype in regulation of several immune responses may explain the severe immune dysfunction in AIDS. However, it is unlikely that the mere depletion of CD4+ T cells can explain the wide range of humoral and cellular abnormalities, including T-helper function2, 3, 7, 8, specific and non-specific cytotoxic activities9–11, B-cell2, 3, 8 and monocyte function8, 9, 12, 13. Furthermore, immunological abnormalities have been observed in asymptomatic HIV-infected people with normal CD4+ T cell numbers, indicating that HIV affects the immune system before T cell depletion ensues. More... »

PAGES

75-89

Book

TITLE

Immunology of HIV Infection

ISBN

978-94-010-5324-2
978-94-011-2980-0

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-011-2980-0_5

DOI

http://dx.doi.org/10.1007/978-94-011-2980-0_5

DIMENSIONS

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