The biological importance of the formation of nitric oxide from L-arginine View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1990

AUTHORS

Richard M. J. Palmer , Salvador Moncada

ABSTRACT

Nitric oxide (NO) is synthesised from the terminal guanidino nitrogen atoms of L-arginine by the vascular endothelium, cytotoxic macrophages, neutrophils and brain synaptosomes. The enzyme(s) responsible are soluble, NADPH-dependent and require a divalent cation, which has been identified as Ca2+ in brain synaptosomes, and are inhibited by L-NG-monomethyl arginine (L-NMMA). Endothelial NO plays a role in the control of vascular tone and of platelet-vessel wall interactions through activation of soluble guanylate cyclase. L-NMMA induces a hypertensive response in vivo, demonstrating the importance of endothelial NO synthesis in the maintenance of blood pressure. The synthesis of NO contributes to the cytotoxic properties of macrophages and may be involved in intercellular communication in the brain. The formation of NO is therefore a widespread transduction mechanism for the regulation of cell function and communication. More... »

PAGES

839-842

Book

TITLE

Amino Acids

ISBN

978-90-72199-04-1
978-94-011-2262-7

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-011-2262-7_101

DOI

http://dx.doi.org/10.1007/978-94-011-2262-7_101

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025033407


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