Heterogeneous Bioconversion of Ionic Compounds View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1993

AUTHORS

L. A. M. van der Wielen , M. J. van Buel , K. Ch. A. M. Luyben

ABSTRACT

Many industrially relevant reactions catalyzed by immobilized enzymes generate protons or hydroxyl ions. The rate of transport of these compounds is limited by slower moving ionic biomolecules due to electrostatic coupling. This leads to a pH-gradient inside the particles which causes a sharp decline in the efficiency of the biocatalyst in case of pH-sensitive conversions. The presence of buffering ions which reversibly bind the H+ or OH- -ions provides a parallel transport route. Optimal design of the biocatalyst and selection of the appropriate operation conditions requires an accurate mathematical description of the complex multi-component reaction-diffusion system. A rigorous transient model is developed which accounts for the electrostatic coupling of the transport of the ionic species and which incorporates buffer facilitated transport of protons or hydroxyl ions. The model is verified experimentally with the penicillin G deacylation reaction which strongly acidifies the reaction medium. More... »

PAGES

493-501

Book

TITLE

Precision Process Technology

ISBN

978-94-010-4772-2
978-94-011-1759-3

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-011-1759-3_38

DOI

http://dx.doi.org/10.1007/978-94-011-1759-3_38

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002567093


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