Adsorptive and Chromatographic Bioreactors View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1993

AUTHORS

L. A. M. Van Der Wielen , A. J. J. Straathof , K. Ch. A. M. Luyben

ABSTRACT

Combination of bioconversion and sorption in a single step.may improve the efficiency of biotechnological processes. Sorptive separation can be controlled either by equilibrium for selective removal of products (adsorptive bioreaction) or by kinetics for the spatial separation of the reacting species (chromatographic bioreaction). The choice between these options depends on the specific motive for integration and on the physico-chemical characteristics of the bioconversion system. Constraints with respect to process configuration and mode of operation are described in this paper for both classes of integrated bioreactor systems. Adsorptive bioreaction is especially interesting for secondary metabolite producing fermentation processes which are hampered either by metabolic control mechanisms or product degradation. Chromatographic bioreaction is mainly the domain of enzyme catalyzed conversions. The main motives are the possibility to achieve conversions well above the thermodynamic equilibrium and simultaneous purification of the products. More... »

PAGES

353-379

References to SciGraph publications

Book

TITLE

Precision Process Technology

ISBN

978-94-010-4772-2
978-94-011-1759-3

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-011-1759-3_27

DOI

http://dx.doi.org/10.1007/978-94-011-1759-3_27

DIMENSIONS

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51 schema:description Combination of bioconversion and sorption in a single step.may improve the efficiency of biotechnological processes. Sorptive separation can be controlled either by equilibrium for selective removal of products (adsorptive bioreaction) or by kinetics for the spatial separation of the reacting species (chromatographic bioreaction). The choice between these options depends on the specific motive for integration and on the physico-chemical characteristics of the bioconversion system. Constraints with respect to process configuration and mode of operation are described in this paper for both classes of integrated bioreactor systems. Adsorptive bioreaction is especially interesting for secondary metabolite producing fermentation processes which are hampered either by metabolic control mechanisms or product degradation. Chromatographic bioreaction is mainly the domain of enzyme catalyzed conversions. The main motives are the possibility to achieve conversions well above the thermodynamic equilibrium and simultaneous purification of the products.
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